ENSDARG00000002956


Danio rerio
integrinsi:dkey-32n7.4cellalphamembranesurfaceinteractionschainvonwillebrandfactortypefg-gaprepeatbeta-propelloralpha-domainsuperfamilyadhesionintegrin-mediatedsignalingpathwaycomplexintegralcomponentvascularwallecmproteoglycansneutrophildegranulation

Features
Gene ID: ENSDARG00000002956
  
Biological name :si:dkey-32n7.4
  
Synonyms : si:dkey-32n7.4
  
Possible biological names infered from orthology : Integrin alpha-D / integrin alpha M / Integrin alpha-X / integrin subunit alpha D / integrin subunit alpha M / integrin subunit alpha X / ITGAD / ITGAM / ITGAX / P11215 / P20702 / Q13349 / Q3V0T4 / Q9QXH4
  
Species: Danio rerio
  
Chr. number: 12
Strand: 1
Band:
Gene start: 4114401
Gene end: 4145033
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000014655
Ensembl peptide - ENSDARP00000129555
NCBI entrez gene - 101882585     See in Manteia.
swissprot - F1QSJ9
ZFIN ID - ZDB-GENE-110411-175
Ensembl - ENSDARG00000002956
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000041298Gallus gallus
 ITGADENSG00000156886Homo sapiens
 ITGAMENSG00000169896Homo sapiens
 ITGAXENSG00000140678Homo sapiens
 ItgadENSMUSG00000070369Mus musculus
 ItgamENSMUSG00000108596Mus musculus
 ItgamENSMUSG00000030786Mus musculus
 ItgaxENSMUSG00000030789Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
itgam / integrin, alpha M (complement component 3 receptor 3 subunit) / ITGAD* / ITGAX* / P11215* / P20702* / Q13349* / Q3V0T4* / Q9QXH4* / integrin alpha M* / Integrin alpha-X * / Integrin...ENSDARG0000009658749
itga11a / integrin, alpha 11a / ITGA11* / Q9UKX5* / integrin subunit alpha 11*ENSDARG0000003608626
itga2.2 / integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), tandem duplicate 2 / ITGA2* / P17301* / Q62469* / Integrin alpha-2 * / integrin subunit alpha 2*ENSDARG0000006297426
itga10 / integrin, alpha 10 / O75578* / integrin subunit alpha 10*ENSDARG0000000250725
itga11b / integrin, alpha 11b / ITGA11* / Q9UKX5* / integrin subunit alpha 11*ENSDARG0000000795025
zmp:0000001082 / ITGAL* / P20701* / P24063* / Integrin alpha-L * / integrin subunit alpha L*ENSDARG0000009889924
itga1 / integrin, alpha 1 / P56199* / Q3V3R4* / integrin subunit alpha 1*ENSDARG0000007431623
itgae.2 / integrin, alpha E, tandem duplicate 2 / ITGAE* / P38570* / Q60677* / integrin subunit alpha E* / integrin alpha E, epithelial-associated*ENSDARG0000005778722
itga3a / integrin, alpha 3a / ITGA3* / P26006* / Q62470* / integrin subunit alpha 3* / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain*ENSDARG0000003791718
itgav / integrin, alpha V / P06756* / integrin subunit alpha V*ENSDARG0000000631417
itga5 / integrin, alpha 5 (fibronectin receptor, alpha polypeptide) / P08648* / P11688* / integrin subunit alpha 5* / Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain*ENSDARG0000000635317
itga3b / integrin, alpha 3b / ITGA3* / P26006* / Q62470* / integrin subunit alpha 3* / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain*ENSDARG0000001282417
itga9 / integrin, alpha 9 / Q13797* / integrin subunit alpha 9*ENSDARG0000003243517
itga6b / integrin, alpha 6b / ITGA6* / P23229* / Q61739* / integrin subunit alpha 6* / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain*ENSDARG0000006994617
itga8 / integrin, alpha 8 / P53708* / A2ARA8* / integrin subunit alpha 8* / Integrin alpha-8 Integrin alpha-8 heavy chain Integrin alpha-8 light chain*ENSDARG0000007871717
itga4 / integrin alpha 4 / P13612* / integrin subunit alpha 4*ENSDARG0000010305617
itga2b / integrin, alpha 2b / P08514* / Q9QUM0* / integrin subunit alpha 2b*ENSDARG0000001868716
itga6a / integrin, alpha 6a / ITGA6* / P23229* / Q61739* / integrin subunit alpha 6* / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain*ENSDARG0000004228216
itga6l / integrin, alpha 6, like / ITGA6* / P23229* / Q61739* / integrin subunit alpha 6* / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain*ENSDARG0000005601816
itgae.1 / integrin, alpha E, tandem duplicate 1 / ITGAE* / P38570* / Q60677* / integrin subunit alpha E* / integrin alpha E, epithelial-associated*ENSDARG000000980127


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR002035  von Willebrand factor, type A
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR032695  Integrin domain superfamily


Gene Ontology (GO)
cell adhesioncell communicationcellular response to stimuluscell adhesioncell communicationcellular response to stimuluscell adhesioncell communicationcellular response to stimuluscell adhesioncell communicationcellular response to stimuluscell adhesioncell communicationcellular response to stimuluscell adhesioncell communicationcellular response to stimuluscell adhesioncell communicationcellular response to stimuluscell adhesioncell communicationcellular response to stimuluscell adhesioncell communicationcellular response to stimuluscell adhesioncell communicationcellular response to stimuluscell adhesioncell adhesioncell communicationcell communicationcellular response to stimuluscellular response to stimulus
cellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellcellmembranemembraneprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
Integrin cell surface interactions
ECM proteoglycans
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000008969 fgb / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*  / complex / reaction
 ENSDARG00000020741 fga / fibrinogen alpha chain / E9PV24* / P02671* / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain*  / complex / reaction
 ENSDARG00000071863 itgb1a / integrin, beta 1a / ITGB1* / P05556* / P09055* / Integrin beta-1 * / integrin subunit beta 1*  / complex
 ENSDARG00000037281 fgg / fibrinogen gamma chain / P02679* / Q8VCM7*  / complex / reaction
 ENSDARG00000114589 jam3a / junctional adhesion molecule 3a / JAM3* / Q9BX67* / Q9D8B7* / junctional adhesion molecule 3* / Junctional adhesion molecule C *  / complex / reaction
 ENSDARG00000016939 itgb2 / integrin, beta 2 / Itgb2l* / P05107* / Q3UV74* / integrin subunit beta 2* / Integrin beta-2-like protein *  / complex






 

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