Manteia

ENSDARG00000021948

Danio rerio

Features

Gene ID:	ENSDARG00000021948

Biological name :	tnc

Synonyms :	tenascin C / tnc

Possible biological names infered from orthology :	P24821 / Q80YX1

Species:	Danio rerio

Chr. number:	5
Strand:	-1
Band:
Gene start:	28560847
Gene end:	28679135

Corresponding Affymetrix probe sets:	Dr.9638.1.A1_a_at (Zebrafish Array) Dr.9638.1.S1_a_at (Zebrafish Array) NM_130907_at (Zebrafish Genome Array with custom cdf files)

Cross references:	Ensembl peptide - ENSDARP00000114191 Ensembl peptide - ENSDARP00000010247 Ensembl peptide - ENSDARP00000146747 Ensembl peptide - ENSDARP00000154936 Ensembl peptide - ENSDARP00000116907 Ensembl peptide - ENSDARP00000144742 NCBI entrez gene - 30037 See in Manteia. RefSeq - XM_017356031 RefSeq - XM_017356032 RefSeq - XM_021475994 RefSeq - NM_001312916 RefSeq - NM_130907 RefSeq Peptide - NP_001299845 RefSeq Peptide - NP_570982 swissprot - F1R5T0 swissprot - E9QHI1 swissprot - F1QYE2 ZFIN ID - ZDB-GENE-980526-104 Ensembl - ENSDARG00000021948

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
zmp:0000000846 / TNC* / P24821* / tenascin C*	ENSDARG00000078362	54
tnr / tenascin R (restrictin, janusin) / Q8BYI9* / Q92752* / tenascin R*	ENSDARG00000020771	32
tnn / tenascin N / Q80Z71* / Q9UQP3*	ENSDARG00000024829	20
fn1a / fibronectin 1a / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*	ENSDARG00000019815	19
tnxba / tenascin XBa / TNXB* / P22105* / tenascin XB*	ENSDARG00000001760	18
fn1b / fibronectin 1b / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*	ENSDARG00000006526	18
fga / fibrinogen alpha chain / E9PV24* / P02671* / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain*	ENSDARG00000020741	7
fgb / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*	ENSDARG00000008969	6
angptl4 / angiopoietin-like 4 / Q9BY76* / Q9Z1P8* / Angiopoietin-related protein 4 *	ENSDARG00000035859	6
fgg / fibrinogen gamma chain / P02679* / Q8VCM7*	ENSDARG00000037281	6
angptl3 / angiopoietin-like 3 / Q9R182* / Q9Y5C1* / Angiopoietin-related protein 3 ANGPTL3(17-224)*	ENSDARG00000044365	6
fgl1 / fibrinogen-like 1 / Q08830*	ENSDARG00000105380	6
angptl5 / angiopoietin-like 5 / Q86XS5*	ENSDARG00000056630	5
si:ch211-287a12.9	ENSDARG00000057004	5
zgc:194887	ENSDARG00000098586	4

Protein motifs (from Interpro)

Interpro ID	Name
IPR000742	EGF-like domain
IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
IPR003961	Fibronectin type III
IPR013032	EGF-like, conserved site
IPR013111	EGF-like domain, extracellular
IPR013783	Immunoglobulin-like fold
IPR014715	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
IPR033078	Tenascin-C

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001755	neural crest cell migration	IEP
biological_process	GO:0007155	cell adhesion	IEA
biological_process	GO:0007411	axon guidance	IMP
biological_process	GO:0007413	axonal fasciculation	IMP
biological_process	GO:0007498	mesoderm development	IEP
biological_process	GO:0014814	axon regeneration at neuromuscular junction	IMP
biological_process	GO:0021554	optic nerve development	IMP
biological_process	GO:0030517	negative regulation of axon extension	IMP
biological_process	GO:0042127	regulation of cell proliferation	IEA
biological_process	GO:0045887	positive regulation of synaptic growth at neuromuscular junction	IMP
biological_process	GO:0048680	positive regulation of axon regeneration	IMP
cellular_component	GO:0031012	extracellular matrix	IEA

Pathways (from Reactome)

Pathway description

Integrin cell surface interactions

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000094	blood island	blood island nucleate erythrocyte aggregated , abnormal	Show
ZFA:0000543	medial longitudinal fasciculus	medial longitudinal fasciculus axon decreased amount , abnormal	Show
ZFA:0001094	whole organism	whole organism movement quality , abnormal	Show
ZFA:0001114	head	head decreased position , abnormal	Show
ZFA:0009052	motor neuron	motor neuron axon truncated , abnormal motor neuron axon defasciculated , abnormal motor neuron axon increased branchiness , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSDARG00000032435	itga9 / integrin, alpha 9 / Q13797* / integrin subunit alpha 9*	/ complex / reaction
ENSDARG00000021948	tnc / tenascin C / P24821* / Q80YX1*	/ complex
ENSDARG00000071863	itgb1a / integrin, beta 1a / ITGB1* / P05556* / P09055* / Integrin beta-1 * / integrin subunit beta 1*	/ complex / reaction
ENSDARG00000078362	zmp:0000000846 / TNC* / P24821* / tenascin C*	/ complex
ENSDARG00000006526	fn1b / fibronectin 1b / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*	/ complex / reaction
ENSDARG00000019815	fn1a / fibronectin 1a / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr