ENSGALG00000032496


Gallus gallus

Features
Gene ID: ENSGALG00000032496
  
Biological name :SIRT3
  
Synonyms : SIRT3 / sirtuin 3
  
Possible biological names infered from orthology : Q8R104 / Q9NTG7
  
Species: Gallus gallus
  
Chr. number: 5
Strand: 1
Band:
Gene start: 1582252
Gene end: 1586385
  
Corresponding Affymetrix probe sets: Gga.5177.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000045440
NCBI entrez gene - 422988     See in Manteia.
RefSeq - NM_001199493
RefSeq - XM_015286200
RefSeq Peptide - NP_001186422
swissprot - A0A1D5NYI2
Ensembl - ENSGALG00000032496
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sirt3ENSDARG00000035819Danio rerio
 SIRT3ENSG00000142082Homo sapiens
 Sirt3ENSMUSG00000025486Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SIRT2 / NAD-dependent protein deacetylase sirtuin-2 / Q8IXJ6* / Q8VDQ8* / sirtuin 2*ENSGALG0000002976145


Protein motifs (from Interpro)
Interpro ID Name
 IPR003000  Sirtuin family
 IPR017328  Sirtuin, class I
 IPR026590  Sirtuin family, catalytic core domain
 IPR026591  Sirtuin, catalytic core small domain superfamily
 IPR029035  DHS-like NAD/FAD-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006476 protein deacetylation IEA
 biological_processGO:0009060 aerobic respiration IEA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0034983 peptidyl-lysine deacetylation IEA
 biological_processGO:1903109 positive regulation of mitochondrial transcription IEA
 biological_processGO:2000757 negative regulation of peptidyl-lysine acetylation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017136 NAD-dependent histone deacetylase activity IEA
 molecular_functionGO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070403 NAD+ binding IEA


Pathways (from Reactome)
Pathway description
Transcriptional activation of mitochondrial biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003362 ACSS2 / acyl-CoA synthetase short chain family member 2 / Q9NR19* / Q9QXG4* / Acetyl-coenzyme A synthetase, cytoplasmic *  / reaction
 ENSGALG00000011661 SOD2 / superoxide dismutase / P09671* / P04179* / superoxide dismutase 2* / superoxide dismutase 2, mitochondrial*  / reaction
 ENSGALG00000034434 IDH2 / isocitrate dehydrogenase / P54071* / P48735* / Isocitrate dehydrogenase [NADP], mitochondrial * / isocitrate dehydrogenase (NADP(+)) 2, mitochondrial*  / reaction
 ENSGALG00000034735 GLUD1* / GLUD2* / P49448* / P00367* / P26443* / glutamate dehydrogenase 1* / glutamate dehydrogenase 2* / Glutamate dehydrogenase 1, mitochondrial *  / reaction






 

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