ENSDARG00000035819


Danio rerio

Features
Gene ID: ENSDARG00000035819
  
Biological name :sirt3
  
Synonyms : sirt3 / sirtuin 3
  
Possible biological names infered from orthology : Q8R104 / Q9NTG7
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 57465814
Gene end: 57509768
  
Corresponding Affymetrix probe sets: Dr.14871.1.A1_at (Zebrafish Array)   Dr.17197.1.A1_at (Zebrafish Array)   NM_001080174_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000051972
Ensembl peptide - ENSDARP00000153898
Ensembl peptide - ENSDARP00000119230
NCBI entrez gene - 558775     See in Manteia.
RefSeq - NM_001080174
RefSeq Peptide - NP_001073643
swissprot - B0S7D4
swissprot - A1L2B7
ZFIN ID - ZDB-GENE-070112-1762
Ensembl - ENSDARG00000035819
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SIRT3ENSGALG00000032496Gallus gallus
 SIRT3ENSG00000142082Homo sapiens
 Sirt3ENSMUSG00000025486Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
si:dkey-103i16.6ENSDARG0000006289346
sirt2 / sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) / Q8VDQ8* / Q8IXJ6* / sirtuin 2* / NAD-dependent protein deacetylase sirtuin-2 *ENSDARG0000001148842


Protein motifs (from Interpro)
Interpro ID Name
 IPR003000  Sirtuin family
 IPR017328  Sirtuin, class I
 IPR026590  Sirtuin family, catalytic core domain
 IPR029035  DHS-like NAD/FAD-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016575 histone deacetylation IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017136 NAD-dependent histone deacetylase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070403 NAD+ binding IEA


Pathways (from Reactome)
Pathway description
Transcriptional activation of mitochondrial biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003795 idh2 / isocitrate dehydrogenase 2 (NADP+), mitochondrial / P48735* / isocitrate dehydrogenase (NADP(+)) 2, mitochondrial*  / reaction
 ENSDARG00000042644 sod2 / superoxide dismutase 2, mitochondrial / P04179* / P09671* / superoxide dismutase 2*  / reaction
 ENSDARG00000101074 glud1b / glutamate dehydrogenase 1b / GLUD1* / GLUD2* / P49448* / P00367* / P26443* / glutamate dehydrogenase 1* / glutamate dehydrogenase 2* / Glutamate dehydrogenase 1, mitochondrial *  / reaction






 

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