ENSGALG00000037410


Gallus gallus

Features
Gene ID: ENSGALG00000037410
  
Biological name :HEPH
  
Synonyms : HEPH / hephaestin
  
Possible biological names infered from orthology : Q9BQS7 / Q9Z0Z4
  
Species: Gallus gallus
  
Chr. number: 4
Strand: 1
Band:
Gene start: 284344
Gene end: 322060
  
Corresponding Affymetrix probe sets: Gga.12579.1.S1_at (Chicken Array)   Gga.16577.1.S1_at (Chicken Array)   GgaAffx.26270.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000048097
Ensembl peptide - ENSGALP00000049958
NCBI entrez gene - 422168     See in Manteia.
RefSeq - XM_004940526
RefSeq - XM_015285254
RefSeq - XM_420165
swissprot - A0A1D5PB38
swissprot - A0A1D5P5X4
Ensembl - ENSGALG00000037410
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hephl1aENSDARG00000059231Danio rerio
 HEPHENSG00000089472Homo sapiens
 HephENSMUSG00000031209Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HEPHL1 / hephaestin like 1 / Q3V1H3* / Q6MZM0* / Hephaestin-like protein 1 *ENSGALG0000004302752
ENSGALG0000003077350
F8 / coagulation factor VIII / P00451* / Q06194*ENSGALG0000000507734
F5 / coagulation factor V / O88783* / P12259* / Coagulation factor V Coagulation factor V heavy chain Coagulation factor V light chain*ENSGALG0000002929833
NRP1 / neuropilin-1 precursor / O14786* / P97333* / neuropilin 1*ENSGALG000000071406
NRP2 / neuropilin-2 precursor / O35375* / O60462* / neuropilin 2*ENSGALG000000086216
DCBLD1 / discoidin, CUB and LCCL domain containing 1 / Q8N8Z6* / Q9D4J3* / Mus musculus discoidin, CUB and LCCL domain containing 1 (Dcbld1), transcript variant 2, mRNA.*ENSGALG000000149075
ENSGALG000000290665
MFGE8 / lactadherin isoform 2 precursor / P21956* / Q08431* / milk fat globule-EGF factor 8 protein*ENSGALG000000067024
DCBLD2 / discoidin, CUB and LCCL domain-containing protein 2 precursor / Q91ZV3* / Q96PD2* / discoidin, CUB and LCCL domain containing 2* / Mus musculus discoidin, CUB and LCCL domain cont...ENSGALG000000152584
EDIL3 / EGF like repeats and discoidin domains 3 / O35474* / O43854* / EGF-like repeat and discoidin I-like domain-containing protein 3 *ENSGALG000000156304
RS1 / retinoschisin 1 / O15537* / Q9Z1L4* / retinoschisis (X-linked, juvenile) 1 (human)*ENSGALG000000165233


Protein motifs (from Interpro)
Interpro ID Name
 IPR002355  Multicopper oxidase, copper-binding site
 IPR008972  Cupredoxin
 IPR011706  Multicopper oxidase, type 2
 IPR011707  Multicopper oxidase, type 3
 IPR027154  Hephaestin
 IPR033138  Multicopper oxidases, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006826 iron ion transport IEA
 biological_processGO:0006879 cellular iron ion homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 molecular_functionGO:0004322 ferroxidase activity IEA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0008198 ferrous iron binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Metal ion SLC transporters
Iron uptake and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000043618 SLC40A1 / solute carrier family 40 member 1 / Q9JHI9* / Q9NP59* / solute carrier family 40 (iron-regulated transporter), member 1*  / complex






 

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