ENSGALG00000041222


Gallus gallus

Features
Gene ID: ENSGALG00000041222
  
Biological name :CYP7A1
  
Synonyms : cholesterol 7-alpha-monooxygenase / CYP7A1
  
Possible biological names infered from orthology : cytochrome P450 family 7 subfamily A member 1 / P22680 / Q64505
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 112384150
Gene end: 112391681
  
Corresponding Affymetrix probe sets: GgaAffx.21824.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000054104
Ensembl peptide - ENSGALP00000060096
NCBI entrez gene - 414834     See in Manteia.
RefSeq - NM_001001753
RefSeq Peptide - NP_001001753
swissprot - A0A1L1RMV0
swissprot - A0A1D5PMM2
Ensembl - ENSGALG00000041222
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp7a1ENSDARG00000069018Danio rerio
 CYP7A1ENSG00000167910Homo sapiens
 Cyp7a1ENSMUSG00000028240Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CYP7B1 / cytochrome P450 family 7 subfamily B member 1 / O75881* / Q60991* / 25-hydroxycholesterol 7-alpha-hydroxylase *ENSGALG0000002943541
CYP8B1 / cytochrome P450, family 8, subfamily B / Q9UNU6* / cytochrome P450 family 8 subfamily B member 1*ENSGALG0000003351126
CYP39A1 / cytochrome P450 family 39 subfamily A member 1 / Q9JKJ9* / Q9NYL5* / 24-hydroxycholesterol 7-alpha-hydroxylase *ENSGALG0000001671020


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002403  Cytochrome P450, E-class, group IV
 IPR024204  Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
 IPR030681  Cholesterol 7-alpha-monooxygenase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006699 bile acid biosynthetic process IEA
 biological_processGO:0006707 cholesterol catabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070857 regulation of bile acid biosynthetic process IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008123 cholesterol 7-alpha-monooxygenase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Endogenous sterols


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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