ENSGALG00000043082


Gallus gallus
bindingDHX36rnairfhelicasednadomainactivationregulationactivitymediatedtypehydrolaseresponsetranscriptiontelomeraseg-quadruplextrafc-terminalatp-dependentdeah-boxconservedsitehelicase-associateddeaddeahboxunknownfunctiondufsuperfamily

Features
Gene ID: ENSGALG00000043082
  
Biological name :DHX36
  
Synonyms : DEAH-box helicase 36 / DHX36
  
Possible biological names infered from orthology : ATP-dependent RNA helicase DHX36 / Q8VHK9 / Q9H2U1
  
Species: Gallus gallus
  
Chr. number: 9
Strand: 1
Band:
Gene start: 23286957
Gene end: 23303895
  
Corresponding Affymetrix probe sets: Gga.6977.1.S1_at (Chicken Array)   Gga.6977.2.S1_at (Chicken Array)   GgaAffx.23208.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000052194
NCBI entrez gene - 425032     See in Manteia.
RefSeq - XM_015291824
swissprot - A0A1D5PHB6
Ensembl - ENSGALG00000043082
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dhx36ENSDARG00000101059Danio rerio
 DHX36ENSG00000174953Homo sapiens
 Dhx36ENSMUSG00000027770Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DHX57 / DExH-box helicase 57 / Q6P158* / Q6P5D3* / Putative ATP-dependent RNA helicase DHX57 *ENSGALG0000004155840
DHX29 / DExH-box helicase 29 / Q6PGC1* / Q7Z478* / ATP-dependent RNA helicase DHX29 *ENSGALG0000001470035
DHX30 / putative ATP-dependent RNA helicase DHX30 precursor / Q99PU8* / Q7L2E3* / DExH-box helicase 30* / Putative ATP-dependent RNA helicase DHX30 *ENSGALG0000003983029
TDRD9 / tudor domain containing 9 / Q14BI7* / Q8NDG6* / ATP-dependent RNA helicase TDRD9 *ENSGALG0000001156524
B2RR83* / Q9H6S0* / YTHDC2* / YTH domain containing 2*ENSGALG0000000018919
B2RR83* / Q9H6S0* / YTHDC2* / YTH domain containing 2*ENSGALG0000002968112


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR002464  DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
 IPR007502  Helicase-associated domain
 IPR011545  DEAD/DEAH box helicase domain
 IPR011709  Domain of unknown function DUF1605
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
ossificationresponse to external stimulusresponse to biotic stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationregulation of biological qualityresponse to chemicalbiosynthetic processcatabolic processmacromolecule localizationestablishment of localizationcytokine productionossificationresponse to external stimulusresponse to biotic stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationregulation of biological qualityresponse to chemicalbiosynthetic processcatabolic processmacromolecule localizationestablishment of localizationcytokine productionossificationresponse to external stimulusresponse to biotic stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationregulation of biological qualityresponse to chemicalbiosynthetic processcatabolic processmacromolecule localizationestablishment of localizationcytokine productionossificationresponse to external stimulusresponse to biotic stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationregulation of biological qualityresponse to chemicalbiosynthetic processcatabolic processmacromolecule localizationestablishment of localizationcytokine productionossificationresponse to external stimulusresponse to biotic stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationregulation of biological qualityresponse to chemicalbiosynthetic processcatabolic processmacromolecule localizationestablishment of localizationcytokine productionossificationresponse to external stimulusresponse to biotic stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationregulation of biological qualityresponse to chemicalbiosynthetic processcatabolic processmacromolecule localizationestablishment of localizationcytokine productionossificationresponse to external stimulusresponse to biotic stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationregulation of biological qualityresponse to chemicalbiosynthetic processcatabolic processmacromolecule localizationestablishment of localizationcytokine productionossificationresponse to external stimulusresponse to biotic stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationregulation of biological qualityresponse to chemicalbiosynthetic processcatabolic processmacromolecule localizationestablishment of localizationcytokine productionossificationresponse to external stimulusresponse to biotic stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationregulation of biological qualityresponse to chemicalbiosynthetic processcatabolic processmacromolecule localizationestablishment of localizationcytokine productionossificationresponse to external stimulusresponse to biotic stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationregulation of biological qualityresponse to chemicalbiosynthetic processcatabolic processmacromolecule localizationestablishment of localizationcytokine productionossificatossificationresponse response to external stimulusresponse response to biotic stimulusnitrogen nitrogen compound metabolic processcellular cellular metabolic processprimary mprimary metabolic processorganic sorganic substance metabolic processcellular cellular component organizationregulatioregulation of biological qualityresponse response to chemicalbiosynthebiosynthetic processcataboliccatabolic processmacromolemacromolecule localizationestablishestablishment of localizationcytokine cytokine production
organic cyclic compound bindingheterocyclic compound bindingsmall molecule bindinghydrolase activityion bindingcarbohydrate derivative bindingdrug bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindinghydrolase activityion bindingcarbohydrate derivative bindingdrug bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindinghydrolase activityion bindingcarbohydrate derivative bindingdrug bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindinghydrolase activityion bindingcarbohydrate derivative bindingdrug bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindinghydrolase activityion bindingcarbohydrate derivative bindingdrug bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindinghydrolase activityion bindingcarbohydrate derivative bindingdrug bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindinghydrolase activityion bindingcarbohydrate derivative bindingdrug bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindinghydrolase activityion bindingcarbohydrate derivative bindingdrug bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindinghydrolase activityion bindingcarbohydrate derivative bindingdrug bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindinghydrolase activityion bindingcarbohydrate derivative bindingdrug bindingprotein bindingorganic cyclic coorganic cyclic compound bindingheterocyclic compheterocyclic compound bindingsmall molecule bismall molecule bindinghydrolase activithydrolase activityion bindingion bindingcarbohydrate dericarbohydrate derivative bindingdrug bindingdrug bindingprotein bindingprotein binding
cellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellcellorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0010501 RNA secondary structure unwinding IEA
 biological_processGO:0032206 positive regulation of telomere maintenance IEA
 biological_processGO:0043330 response to exogenous dsRNA IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0090669 telomerase RNA stabilization IEA
 biological_processGO:1902741 positive regulation of interferon-alpha secretion IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0002151 G-quadruplex RNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0051880 G-quadruplex DNA binding IEA
 molecular_functionGO:0070034 telomerase RNA binding IEA


Pathways (from Reactome)
Pathway description
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
TICAM1-dependent activation of IRF3/IRF7
TRAF6 mediated IRF7 activation
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000005947 MYD88 / A5HNF6 / Myeloid differentiation primary response protein MyD88 / Q99836* / P22366* / myeloid differentiation primary response 88* / myeloid differentiation primary response gene 88*  / complex / reaction






 

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