ENSMUSG00000000093


Mus musculus

Features
Gene ID: ENSMUSG00000000093
  
Biological name :Tbx2
  
Synonyms : Q60707 / T-box transcription factor TBX2 / Tbx2
  
Possible biological names infered from orthology : Q13207 / T-box 2
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: C
Gene start: 85832551
Gene end: 85841948
  
Corresponding Affymetrix probe sets: 10379936 (MoGene1.0st)   1422545_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000095
NCBI entrez gene - 21385     See in Manteia.
MGI - MGI:98494
RefSeq - NM_009324
RefSeq Peptide - NP_033350
swissprot - Q60707
Ensembl - ENSMUSG00000000093
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbx2aENSDARG00000018025Danio rerio
 tbx2bENSDARG00000006120Danio rerio
 TBX2ENSGALG00000034297Gallus gallus
 TBX2ENSG00000121068Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tbx3 / P70324 / T-box 3 / O15119*ENSMUSG0000001860459
Tbx4 / P70325 / T-box 4 / P57082*ENSMUSG0000000009423
Tbx5 / P70326 / T-box 5 / Q99593*ENSMUSG0000001826323
Tbx1 / T-box 1 / O43435*ENSMUSG0000000909722
Tbx15 / O70306 / T-box transcription factor TBX15 / Q96SF7* / T-box 15*ENSMUSG0000002786822
Tbx6 / P70327 / T-box transcription factor TBX6 / O95947* / T-box 6*ENSMUSG0000003069922
Tbx18 / T-box 18 / O95935*ENSMUSG0000003241922
Tbx20 / Q9ES03 / T-box transcription factor TBX20 / Q9UMR3* / T-box 20*ENSMUSG0000003196521
Tbx10 / Q810F8 / T-box transcription factor TBX10 / O75333* / T-box 10*ENSMUSG0000003747720
Tbx22 / Q8K402 / T-box 22 / Q9Y458*ENSMUSG0000003124119


Protein motifs (from Interpro)
Interpro ID Name
 IPR001699  Transcription factor, T-box
 IPR002070  Transcription factor, Brachyury
 IPR008967  p53-like transcription factor, DNA-binding
 IPR018186  Transcription factor, T-box, conserved site
 IPR022582  Transcription factor, T-box, region of unknown function
 IPR036960  T-box superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001947 heart looping ISS
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0003148 outflow tract septum morphogenesis IMP
 biological_processGO:0003151 outflow tract morphogenesis IMP
 biological_processGO:0003203 endocardial cushion morphogenesis IMP
 biological_processGO:0003256 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007521 muscle cell fate determination IMP
 biological_processGO:0007569 cell aging IEA
 biological_processGO:0008016 regulation of heart contraction ISS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0035050 embryonic heart tube development ISS
 biological_processGO:0035909 aorta morphogenesis IMP
 biological_processGO:0036302 atrioventricular canal development IMP
 biological_processGO:0042733 embryonic digit morphogenesis IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0048596 embryonic camera-type eye morphogenesis IMP
 biological_processGO:0048738 cardiac muscle tissue development IMP
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IMP
 biological_processGO:0060465 pharynx development IMP
 biological_processGO:0060560 developmental growth involved in morphogenesis IMP
 biological_processGO:0060596 mammary placode formation IGI
 biological_processGO:0090398 cellular senescence IEA
 biological_processGO:1901208 negative regulation of heart looping IMP
 biological_processGO:1901211 negative regulation of cardiac chamber formation IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005667 transcription factor complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Ctnnb1tm1Max/Ctnnb1+,Hesx1tm1Icar/Hesx1tm1Icar
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000298 absent endocardial cushion "absence of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [MGI:CLS]
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Allelic Composition: Ctnnb1tm1Max/Ctnnb1+,Hesx1tm1Icar/Hesx1tm1Icar
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000301 reduced size of endocardial cushions "smaller than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

Allelic Composition: Tbx2tm1.1(cre)Vmc/Tbx2tm1.1(cre)Vmc
Genetic Background: involves: 129P2/OlaHsd * NMRI

Allelic Composition: Tbx2tm1.1(cre)Vmc/Tbx2tm1.1(cre)Vmc
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx3tm1.1(cre)Vmc/Tbx3tm1.1(cre)Vmc
Genetic Background: involves: 129P2/OlaHsd * FVB/N * NMRI

Allelic Composition: Tbx2tm2.1Vmc/Tbx2tm2.1Vmc
Genetic Background: involves: 129S4/SvJaeSor * FVB

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0002925 abnormal cardiovascular development "aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm1Max/Ctnnb1+,Hesx1tm1Icar/Hesx1tm1Icar
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0006107 abnormal atrioventricular canal morphology "malformation or anomaly in development of the common canal connecting the primordial atrium and ventricle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93610]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

Allelic Composition: Tbx2tm1Pa/Tbx2tm1Pa
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Tbx2tm2.2Vmc/Tbx2tm2.2Vmc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * FVB

 MP:0006355 abnormal sixth branchial arch artery morphology "any structural anomaly of the vessels formed within the sixth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0008772 enlarged heart ventricle "increased average size of the heart ventricles compared to the average for a particular population" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0009382 abnormal cardiac jelly morphology "any structural anomaly of the gelatinous noncellular material between the endothelial lining and the myocardial layer of the developing heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm1Max/Ctnnb1+,Hesx1tm1Icar/Hesx1tm1Icar
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0009744 postaxial polydactyly "duplication of all or part of any of the rays except the first ray on one or more of the autopods" [PMID:19125433]
Show

Allelic Composition: Tbx2tm2.2Vmc/Tbx2tm2.2Vmc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * FVB

 MP:0009883 palatal shelf hypoplasia "reduced size of the palatal projections from the inner part of the maxillary processes that fuse to form the secondary palate, often due to reduced cell number" [PMID:16680722]
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Allelic Composition: Tbx2tm1.1(cre)Vmc/Tbx2tm1.1(cre)Vmc
Genetic Background: involves: 129P2/OlaHsd * NMRI

 MP:0009885 abnormal palatal shelf elevation "any anomaly in the process in which the palatal shelves move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
Show

Allelic Composition: Tbx2tm1.1(cre)Vmc/Tbx2tm1.1(cre)Vmc
Genetic Background: involves: 129P2/OlaHsd * NMRI

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * SJL

Allelic Composition: Tbx2tm1.1(cre)Vmc/Tbx2+,Tbx3tm1.1(cre)Vmc/Tbx3+
Genetic Background: involves: 129P2/OlaHsd * FVB/N * NMRI

Allelic Composition: Tbx2tm1.1(cre)Vmc/Tbx2tm1.1(cre)Vmc
Genetic Background: involves: 129P2/OlaHsd * NMRI

 MP:0010454 abnormal truncus arteriosis septation "anomaly in the process of dividing the common arterial trunk arising out of both heart ventricles to divide into the aorta and pulmonary artery during development" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0010587 conotruncal ridge hypoplasia "underdevelopment or reduced size of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298]
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Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * SJL

Allelic Composition: Tbx2tm1.1(cre)Vmc/Tbx2tm1.1(cre)Vmc,Tbx3tm1.1(cre)Vmc/Tbx3+
Genetic Background: involves: 129P2/OlaHsd * FVB/N * NMRI

Allelic Composition: Tbx2tm2.2Vmc/Tbx2tm2.2Vmc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * FVB

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Tbx2tm1Pa/Tbx2tm1Pa
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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