ENSMUSG00000031241


Mus musculus

Features
Gene ID: ENSMUSG00000031241
  
Biological name :Tbx22
  
Synonyms : Q8K402 / T-box 22 / Tbx22
  
Possible biological names infered from orthology : Q9Y458
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: D
Gene start: 107667964
Gene end: 107688978
  
Corresponding Affymetrix probe sets: 10601433 (MoGene1.0st)   1438586_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112544
Ensembl peptide - ENSMUSP00000128247
Ensembl peptide - ENSMUSP00000133607
Ensembl peptide - ENSMUSP00000063611
Ensembl peptide - ENSMUSP00000127321
NCBI entrez gene - 245572     See in Manteia.
MGI - MGI:2389465
RefSeq - XM_017318494
RefSeq - NM_181319
RefSeq - XM_006528039
RefSeq - XM_006528040
RefSeq - XM_017318490
RefSeq - XM_017318491
RefSeq - XM_017318492
RefSeq - XM_017318493
RefSeq - NM_001290747
RefSeq - NM_145224
RefSeq Peptide - NP_001277676
RefSeq Peptide - NP_660259
RefSeq Peptide - NP_851836
swissprot - G3UXA1
swissprot - E9Q5R8
swissprot - Q8BKE4
swissprot - Q8K402
Ensembl - ENSMUSG00000031241
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbx22ENSDARG00000091748Danio rerio
 TBX22ENSGALG00000004093Gallus gallus
 TBX22ENSG00000122145Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tbx15 / O70306 / T-box transcription factor TBX15 / Q96SF7* / T-box 15*ENSMUSG0000002786845
Tbx18 / T-box 18 / O95935*ENSMUSG0000003241942
Tbx20 / Q9ES03 / T-box transcription factor TBX20 / Q9UMR3* / T-box 20*ENSMUSG0000003196530
Tbx1 / T-box 1 / O43435*ENSMUSG0000000909727
Tbx2 / Q60707 / T-box transcription factor TBX2 / Q13207* / T-box 2*ENSMUSG0000000009326
Tbx3 / P70324 / T-box 3 / O15119*ENSMUSG0000001860425
Tbx10 / Q810F8 / T-box transcription factor TBX10 / O75333* / T-box 10*ENSMUSG0000003747725
Tbx5 / P70326 / T-box 5 / Q99593*ENSMUSG0000001826324
Tbx4 / P70325 / T-box 4 / P57082*ENSMUSG0000000009423
Tbx6 / P70327 / T-box transcription factor TBX6 / O95947* / T-box 6*ENSMUSG0000003069922


Protein motifs (from Interpro)
Interpro ID Name
 IPR001699  Transcription factor, T-box
 IPR008967  p53-like transcription factor, DNA-binding
 IPR018186  Transcription factor, T-box, conserved site
 IPR036960  T-box superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000098 abnormal vomer bone morphology "missing triangular flat bone of the nasal septum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

Allelic Composition: Tbx22tm1.1Sta/Y
Genetic Background: involves: 129/Sv * CD-1

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

Allelic Composition: Tbx22tm1.1Sta/Y
Genetic Background: involves: 129/Sv * CD-1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxd13Dyc/Hoxd13Dyc
Genetic Background: BALB/c-Hoxd13Dyc

Allelic Composition: Tbx22tm1Sta/Tbx22tm1Sta
Genetic Background: Not Specified

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

Allelic Composition: Tbx22tm1.1Sta/Y
Genetic Background: involves: 129/Sv * CD-1

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0008273 abnormal intramembranous bone ossification "anomaly in the process of the formation of bone in which osteoblasts secrete a collage-proteoglycan matrix that binds calcium salts and becomes calcified; intramembranous ossification is the way flat bones are formed" [GO:0001957]
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

Allelic Composition: Tbx22tm1.1Sta/Y
Genetic Background: involves: 129/Sv * CD-1

 MP:0008395 abnormal osteoblast differentiation "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

Allelic Composition: Tbx22tm1.1Sta/Y
Genetic Background: involves: 129/Sv * CD-1

 MP:0008970 choanal atresia "blockage of the back of the nasal passageby abnormal bony or soft tissue, usually due to failure of the bucconasal membrane to involute during development" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

Allelic Composition: Tbx22tm1.1Sta/Y
Genetic Background: involves: 129/Sv * CD-1

 MP:0009652 abnormal palatal rugae "any structural anomaly in the transversal ridges that develop on the secondary (hard) palate" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

Allelic Composition: Tbx22tm1.1Sta/Y
Genetic Background: involves: 129/Sv * CD-1

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

Allelic Composition: Tbx22tm1.1Sta/Y
Genetic Background: involves: 129/Sv * CD-1

 MP:0009892 palate bone hypoplasia "reduced size of the maxillary or palatine shelves that comprise the bones of the hard palate, usually due to reduced cell number" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

Allelic Composition: Tbx22tm1.1Sta/Y
Genetic Background: involves: 129/Sv * CD-1

 MP:0009895 decreased palatine shelf size "reduced size of the bony projection of the palatine bone that normally fuses with maxillary shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

Allelic Composition: Tbx22tm1.1Sta/Y
Genetic Background: involves: 129/Sv * CD-1

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

Allelic Composition: Tbx22tm1.1Sta/Y
Genetic Background: involves: 129/Sv * CD-1

 MP:0013264 tongue ankylosis "partial or complete fusion or adherence of the tongue to the floor of the mouth, resulting in varying degrees of restricted tongue mobility; partial ankyloglossia (aka tongue-tie) is caused by a lingual frenulum that is abnormally short or is attached too close to the tip of the tongue; in complete ankyloglossia the tongue is tethered to the floor of the mouth" [MGI:anna]
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

Allelic Composition: Tbx22tm1.1Sta/Y
Genetic Background: involves: 129/Sv * CD-1

 MP:0030183 persistent oronasal membrane "failure of the oronasal membrane to rupture during development leading to choanal obstruction" [PMID:19648291]
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

Allelic Composition: Tbx22tm1.1Sta/Y
Genetic Background: involves: 129/Sv * CD-1

 MP:0030266 small vomer bone "reduced size of the triangular flat bone of the nasal septum" [MGI:anna]
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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