ENSMUSG00000000215


Mus musculus

Features
Gene ID: ENSMUSG00000000215
  
Biological name :Ins2
  
Synonyms : Ins2 / Insulin-2 Insulin-2 B chain Insulin-2 A chain / P01326
  
Possible biological names infered from orthology : INS / insulin / P01308
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F5
Gene start: 142678656
Gene end: 142743381
  
Corresponding Affymetrix probe sets: 10569358 (MoGene1.0st)   1422446_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101553
Ensembl peptide - ENSMUSP00000147425
Ensembl peptide - ENSMUSP00000124643
Ensembl peptide - ENSMUSP00000115147
Ensembl peptide - ENSMUSP00000101554
Ensembl peptide - ENSMUSP00000000220
Ensembl peptide - ENSMUSP00000101550
Ensembl peptide - ENSMUSP00000101551
Ensembl peptide - ENSMUSP00000101552
NCBI entrez gene - 16334     See in Manteia.
MGI - MGI:96573
RefSeq - NM_001185083
RefSeq - NM_001185084
RefSeq - NM_008387
RefSeq Peptide - NP_032413
RefSeq Peptide - NP_001172012
RefSeq Peptide - NP_001172013
swissprot - Q5EEX1
swissprot - D3Z596
swissprot - D3Z595
swissprot - D3YWU5
swissprot - P01326
swissprot - E0CXX7
Ensembl - ENSMUSG00000000215
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 insENSDARG00000035350Danio rerio
 insbENSDARG00000034610Danio rerio
 P67970ENSGALG00000006552Gallus gallus
 INSENSG00000254647Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ins1 / P01325 / Insulin-1 Insulin-1 B chain Insulin-1 A chain / INS* / P01308* / insulin*ENSMUSG0000003580488
AC013548.1 / IGF2* / insulin like growth factor 2*ENSMUSG0000011530212


Protein motifs (from Interpro)
Interpro ID Name
 IPR004825  Insulin
 IPR016179  Insulin-like
 IPR022352  Insulin family
 IPR022353  Insulin, conserved site
 IPR036438  Insulin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000165 MAPK cascade ISO
 biological_processGO:0000187 activation of MAPK activity IDA
 biological_processGO:0002674 negative regulation of acute inflammatory response ISO
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006521 regulation of cellular amino acid metabolic process ISO
 biological_processGO:0006953 acute-phase response ISO
 biological_processGO:0006983 ER overload response IMP
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007520 myoblast fusion IGI
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0008286 insulin receptor signaling pathway ISO
 biological_processGO:0010468 regulation of gene expression IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISO
 biological_processGO:0014902 myotube differentiation IGI
 biological_processGO:0016042 lipid catabolic process IDA
 biological_processGO:0022898 regulation of transmembrane transporter activity ISO
 biological_processGO:0032148 activation of protein kinase B activity ISO
 biological_processGO:0032270 positive regulation of cellular protein metabolic process ISO
 biological_processGO:0032460 negative regulation of protein oligomerization ISO
 biological_processGO:0032880 regulation of protein localization ISO
 biological_processGO:0033861 negative regulation of NAD(P)H oxidase activity ISO
 biological_processGO:0042060 wound healing ISO
 biological_processGO:0042177 negative regulation of protein catabolic process ISO
 biological_processGO:0042325 regulation of phosphorylation IDA
 biological_processGO:0042593 glucose homeostasis ISO
 biological_processGO:0043393 regulation of protein binding IDA
 biological_processGO:0043410 positive regulation of MAPK cascade ISO
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IDA
 biological_processGO:0045725 positive regulation of glycogen biosynthetic process ISO
 biological_processGO:0045740 positive regulation of DNA replication ISO
 biological_processGO:0045818 negative regulation of glycogen catabolic process ISO
 biological_processGO:0045821 positive regulation of glycolytic process ISO
 biological_processGO:0045840 positive regulation of mitotic nuclear division ISO
 biological_processGO:0045861 negative regulation of proteolysis ISO
 biological_processGO:0045922 negative regulation of fatty acid metabolic process ISO
 biological_processGO:0046326 positive regulation of glucose import ISO
 biological_processGO:0046628 positive regulation of insulin receptor signaling pathway ISO
 biological_processGO:0046631 alpha-beta T cell activation ISO
 biological_processGO:0050708 regulation of protein secretion ISO
 biological_processGO:0050709 negative regulation of protein secretion ISO
 biological_processGO:0050715 positive regulation of cytokine secretion ISO
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISO
 biological_processGO:0050995 negative regulation of lipid catabolic process ISO
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0051897 positive regulation of protein kinase B signaling ISO
 biological_processGO:0055089 fatty acid homeostasis ISO
 biological_processGO:0060070 canonical Wnt signaling pathway IGI
 biological_processGO:0060266 negative regulation of respiratory burst involved in inflammatory response ISO
 biological_processGO:0060267 positive regulation of respiratory burst ISO
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
 biological_processGO:1900182 positive regulation of protein localization to nucleus ISO
 biological_processGO:1902952 positive regulation of dendritic spine maintenance ISO
 biological_processGO:1903076 regulation of protein localization to plasma membrane ISO
 biological_processGO:1903427 negative regulation of reactive oxygen species biosynthetic process ISO
 biological_processGO:1990535 neuron projection maintenance ISO
 biological_processGO:2000252 negative regulation of feeding behavior ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005732 small nucleolar ribonucleoprotein complex IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0030141 secretory granule IDA
 cellular_componentGO:0034774 secretory granule lumen TAS
 molecular_functionGO:0002020 protease binding ISO
 molecular_functionGO:0005158 insulin receptor binding ISO
 molecular_functionGO:0005159 insulin-like growth factor receptor binding ISO
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
Insulin processing
Synthesis, secretion, and deacylation of Ghrelin
COPI-mediated anterograde transport
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
IRS activation
Signal attenuation
Insulin receptor signalling cascade
Signaling by Insulin receptor
Insulin receptor recycling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita

Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
Genetic Background: B6.Cg-Ins2Akita Bdkrb2tm1Jfh

 MP:0000136 abnormal microglial cell morphology "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita/J

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Pou4f2tm1Rsd/Pou4f2tm1Rsd
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
Genetic Background: B6.Cg-Ins2Akita Bdkrb2tm1Jfh

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ins2Akita/Ins2Akita,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Ins2Akita Ldlrtm1Her

 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pou4f2tm1Rsd/Pou4f2tm1Rsd
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Dbm3C57BL/6J/?,Ins2Akita/Ins2+
Genetic Background: involves: A/J * C57BL/6J * C57BL/6NSlc

Allelic Composition: Dbm4C57BL/6J/?,Ins2Akita/Ins2+
Genetic Background: involves: A/J * C57BL/6J * C57BL/6NSlc

Allelic Composition: Ins2Akita/Ins2Akita,Rpl13atm1.1Jesc/Rpl13atm1.1Jesc
Genetic Background: FVB.Cg-Rpl13atm1.1Jesc Ins2Akita

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita/J

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
Genetic Background: B6.Cg-Ins2Akita Bdkrb2tm1Jfh

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
Genetic Background: B6.Cg-Ins2Akita Bdkrb2tm1Jfh

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Ntrk2tm1Ddg/Ntrk2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Myh6tm2Jse/Myh6+
Genetic Background: involves: 129S1/Sv

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Pou4f2tm1Rsd/Pou4f2tm1Rsd
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita/J

Allelic Composition: Ins2C95S/Ins2C95S
Genetic Background: C3HeB/FeJ-Ins2C95S

Allelic Composition: Ins2C95S/Ins2+
Genetic Background: C3HeB/FeJ-Ins2C95S

Allelic Composition: Ins2Akita/Ins2Akita,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Ins2Akita Ldlrtm1Her

Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: C.B6N-Ins2Akita

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

Allelic Composition: Ins2Akita/Ins2+
Genetic Background: involves: C57BL/6NSlc

Allelic Composition: Ins2Akita/Ins2+,Rnf213tm1.1Akoi/Rnf213tm1.1Akoi
Genetic Background: involves: C57BL/6N * C57BL/6NSlc

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ntrk2tm1Ddg/Ntrk2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Pou4f2tm1Rsd/Pou4f2tm1Rsd
Genetic Background: involves: 129S4/SvJae

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Pou4f2tm1Rsd/Pou4f2tm1Rsd
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pou4f2tm1Rsd/Pou4f2tm1Rsd
Genetic Background: involves: 129S4/SvJae

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Il10tm1Roer/Il10tm1Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pou4f2tm1Rsd/Pou4f2tm1Rsd
Genetic Background: involves: 129S4/SvJae

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Ntrk2tm1Ddg/Ntrk2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ins2Akita/Ins2Akita,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Ins2Akita Ldlrtm1Her

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Ins2Akita/Ins2Akita,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Ins2Akita Ldlrtm1Her

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita

Allelic Composition: Ins2Akita/Ins2+
Genetic Background: involves: C3H * C57BL/6NJcl * C57BL/6NSlc

Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: C57BL/6-Ins2Akita

Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita/J

Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: C57BL/6-Ins2Akita/J

Allelic Composition: Ins2C95S/Ins2+
Genetic Background: C3HeB/FeJ-Ins2C95S

Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Mnt/Ins2tm1Mnt,Tg(Aire-cre)1Mnt/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: involves: C57BL/6NSlc

Allelic Composition: Ins2Akita/Ins2Akita,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Ins2Akita Ldlrtm1Her

Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: C.B6N-Ins2Akita

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Umodtm1Xrw/Umodtm1Xrw
Genetic Background: 129S/SvEv-Umodtm1Xrw

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il10tm1Roer/Il10tm1Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita

 MP:0001759 increased urine glucose level "a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Il10tm1Roer/Il10tm1Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ins2C95S/Ins2C95S
Genetic Background: C3HeB/FeJ-Ins2C95S

Allelic Composition: Ins2C95S/Ins2+
Genetic Background: C3HeB/FeJ-Ins2C95S

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Umodtm1Xrw/Umodtm1Xrw
Genetic Background: 129S/SvEv-Umodtm1Xrw

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob,Mapk8tm1Wag/Mapk8tm1Wag
Genetic Background: B6.Cg-Lepob Mapk8tm1Wag

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Mnt/Ins2tm1Mnt,Tg(Aire-cre)1Mnt/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lepob/Lepob,Mapk8tm1Wag/Mapk8tm1Wag
Genetic Background: B6.Cg-Lepob Mapk8tm1Wag

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja,Tg(Ins2*Y16A)1Ell/0
Genetic Background: NOD.Cg-Ins1tm1Jja Ins2tm1Jja Tg(Ins2*Y16A)1Ell

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntrk2tm1Ddg/Ntrk2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ins2tm1Jja/Ins2tm1Jja
Genetic Background: NOD.129S2-Ins2tm1Jja

Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myh6tm2Jse/Myh6+
Genetic Background: involves: 129S1/Sv

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: involves: C3H * C57BL/6NJcl * C57BL/6NSlc

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pou4f2tm1Rsd/Pou4f2tm1Rsd
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: C57BL/6-Ins2Akita/J

Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
Genetic Background: B6.Cg-Ins2Akita Bdkrb2tm1Jfh

Allelic Composition: Ins2C95S/Ins2C95S
Genetic Background: C3HeB/FeJ-Ins2C95S

Allelic Composition: Ins2Akita/Ins2Akita,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Ins2Akita Ldlrtm1Her

Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: C.B6N-Ins2Akita

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zap70tm2.1Weis/Zap70tm2.1Weis,Tg(DO11.10)10Dlo/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita/J

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
Genetic Background: B6.Cg-Ins2Akita Bdkrb2tm1Jfh

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Mnt/Ins2tm1Mnt,Tg(Aire-cre)1Mnt/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
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Allelic Composition: Il10tm1Roer/Il10tm1Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Il10tm1Roer/Il10tm1Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

 MP:0002690 akinesia "absence of movement or loss of the ability to move such as temporary or prolonged paralysis or "freezing in place"" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:82238]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita

 MP:0002693 abnormal pancreas physiology "abberrant function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: involves: C57BL/6NSlc

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita

Allelic Composition: Ins2C95S/Ins2+
Genetic Background: C3HeB/FeJ-Ins2C95S

Allelic Composition: Cebpbtm1.1Maka/Cebpbtm1.1Maka,Ins2Akita/Ins2Akita,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NSlc * CBA/J

Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: involves: C57BL/6NSlc

Allelic Composition: Ins2Akita/Ins2Akita,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Ins2Akita Ldlrtm1Her

Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

 MP:0002786 abnormal Leydig cell morphology "malformation or absence of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita

Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
Genetic Background: B6.Cg-Ins2Akita Bdkrb2tm1Jfh

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita/J

 MP:0002869 increased insulin autoantibody level "elevated level of antibodies to insulin present in the sera" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob,Mapk8tm1Wag/Mapk8tm1Wag
Genetic Background: B6.Cg-Lepob Mapk8tm1Wag

Allelic Composition: Ins2tm1Jja/Ins2tm1Jja
Genetic Background: NOD.129S2-Ins2tm1Jja

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Mnt/Ins2tm1Mnt,Tg(Aire-cre)1Mnt/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0002870 decreased insulin autoantibody level "reduced level of antibodies to insulin present in the sera" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob,Mapk8tm1Wag/Mapk8tm1Wag
Genetic Background: B6.Cg-Lepob Mapk8tm1Wag

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: C.B6N-Ins2Akita

Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C.B6N-Ins2Akita

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita/J

 MP:0002972 abnormal cardiac muscle contractility "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

 MP:0003031 acidosis "a pathological state characterized by an increase in the hydrogen ion concentration of arterial blood; caused by an decrease in the concentration of alkaline compounds, or by a increase in the concentration of acidic compounds or carbon dioxide to the body fluids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Ntrk2tm1Ddg/Ntrk2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita

Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: C57BL/6-Ins2Akita

Allelic Composition: Ins2C95S/Ins2+
Genetic Background: C3HeB/FeJ-Ins2C95S

Allelic Composition: Cebpbtm1.1Maka/Cebpbtm1.1Maka,Ins2Akita/Ins2Akita,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NSlc * CBA/J

Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: involves: C57BL/6NSlc

Allelic Composition: Ero1lbGt(P077G11)Wrst/Ero1lb+,Ins2Akita/Ins2+
Genetic Background: involves: 129S2/SvPas * C57BL/6NSlc

Allelic Composition: Ins2Akita/Ins2+
Genetic Background: involves: C57BL/6NSlc

Allelic Composition: Ins2Akita/Ins2+,Rnf213tm1.1Akoi/Rnf213tm1.1Akoi
Genetic Background: involves: C57BL/6N * C57BL/6NSlc

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita/J

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il10tm1Roer/Il10tm1Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Ins2C95S/Ins2+
Genetic Background: C3HeB/FeJ-Ins2C95S

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Mnt/Ins2tm1Mnt,Tg(Aire-cre)1Mnt/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Ins2Akita/Ins2+,Rnf213tm1.1Akoi/Rnf213tm1.1Akoi
Genetic Background: involves: C57BL/6N * C57BL/6NSlc

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ins2C95S/Ins2+
Genetic Background: C3HeB/FeJ-Ins2C95S

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Mnt/Ins2tm1Mnt,Tg(Aire-cre)1Mnt/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0003645 increased number of pancreatic beta cells "greater than normal number of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ntrk2tm1Ddg/Ntrk2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ins2tm1Jja/Ins2tm1Jja
Genetic Background: NOD.129S2-Ins2tm1Jja

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H2g7/H2g7,Ins2tm1Jja/Ins2tm1Jja,Rag1tm1Mom/Rag1tm1Mom,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB * NOD

Allelic Composition: Ins2C95S/Ins2C95S
Genetic Background: C3HeB/FeJ-Ins2C95S

Allelic Composition: Ins2C95S/Ins2+
Genetic Background: C3HeB/FeJ-Ins2C95S

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob,Mapk8tm1Wag/Mapk8tm1Wag
Genetic Background: B6.Cg-Lepob Mapk8tm1Wag

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja,Tg(Ins2*Y16A)1Ell/0
Genetic Background: NOD.Cg-Ins1tm1Jja Ins2tm1Jja Tg(Ins2*Y16A)1Ell

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

 MP:0005145 increased circulating VLDL cholesterol level "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ins2Akita/Ins2Akita,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Ins2Akita Ldlrtm1Her

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ins2Akita/Ins2Akita,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Ins2Akita Ldlrtm1Her

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ins2C95S/Ins2+
Genetic Background: C3HeB/FeJ-Ins2C95S

Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

Allelic Composition: Ins2Akita/Ins2+
Genetic Background: involves: C57BL/6NSlc

Allelic Composition: Ins2Akita/Ins2+,Rnf213tm1.1Akoi/Rnf213tm1.1Akoi
Genetic Background: involves: C57BL/6N * C57BL/6NSlc

 MP:0005216 abnormal pancreatic alpha cell morphology "malformation of the cells of the pancreas that secrete glucagon" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: C57BL/6-Ins2Akita

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita

Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: C57BL/6-Ins2Akita

Allelic Composition: Ins2C95S/Ins2+
Genetic Background: C3HeB/FeJ-Ins2C95S

 MP:0005241 abnormal retinal ganglion layer morphology "anomalous structure of the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita/J

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: C.B6N-Ins2Akita

Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C.B6N-Ins2Akita

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita

Allelic Composition: Ins2Akita/Ins2+
Genetic Background: involves: C3H * C57BL/6NJcl * C57BL/6NSlc

Allelic Composition: Ero1lbGt(P077G11)Wrst/Ero1lb+,Ins2Akita/Ins2+
Genetic Background: involves: 129S2/SvPas * C57BL/6NSlc

Allelic Composition: Ins2Akita/Ins2Akita,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Ins2Akita Ldlrtm1Her

Allelic Composition: Ins2Akita/Ins2+,Rnf213tm1.1Akoi/Rnf213tm1.1Akoi
Genetic Background: involves: C57BL/6N * C57BL/6NSlc

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ins2C95S/Ins2+
Genetic Background: C3HeB/FeJ-Ins2C95S

Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

 MP:0005339 increased susceptibility to atherosclerosis "more likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ins2Akita/Ins2Akita,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Ins2Akita Ldlrtm1Her

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

 MP:0005527 increased glomerular filtration rate "greater than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: C.B6N-Ins2Akita

Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C.B6N-Ins2Akita

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja,Tg(Ins2*Y16A)1Ell/0
Genetic Background: NOD.Cg-Ins1tm1Jja Ins2tm1Jja Tg(Ins2*Y16A)1Ell

Allelic Composition: Dbm1A/J/Dbm1A/J,Ins2Akita/Ins2+
Genetic Background: involves: A/J * C57BL/6J * C57BL/6NSlc

Allelic Composition: H2g7/H2g7,Ins2tm1Jja/Ins2tm1Jja,Rag1tm1Mom/Rag1tm1Mom,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB * NOD

Allelic Composition: Ins2C95S/Ins2C95S
Genetic Background: C3HeB/FeJ-Ins2C95S

Allelic Composition: Ins2C95S/Ins2+
Genetic Background: C3HeB/FeJ-Ins2C95S

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Mnt/Ins2tm1Mnt,Tg(Aire-cre)1Mnt/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Cebpbtm1.1Maka/Cebpbtm1.1Maka,Ins2Akita/Ins2Akita,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NSlc * CBA/J

Allelic Composition: Ero1lbGt(P077G11)Wrst/Ero1lb+,Ins2Akita/Ins2+
Genetic Background: involves: 129S2/SvPas * C57BL/6NSlc

Allelic Composition: Ins2Akita/Ins2+
Genetic Background: involves: C57BL/6NSlc

Allelic Composition: Ins2Akita/Ins2+,Rnf213tm1.1Akoi/Rnf213tm1.1Akoi
Genetic Background: involves: C57BL/6N * C57BL/6NSlc

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: involves: C57BL/6NSlc

Allelic Composition: Ins2Akita/Ins2+,Rnf213tm1.1Akoi/Rnf213tm1.1Akoi
Genetic Background: involves: C57BL/6N * C57BL/6NSlc

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita/J

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita/J

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
Genetic Background: B6.Cg-Ins2Akita Bdkrb2tm1Jfh

 MP:0008070 absent T cells "absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

 MP:0008212 absent mature B cells "absence of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

 MP:0008559 abnormal interferon-gamma secretion "anomaly in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Mnt/Ins2tm1Mnt,Tg(Aire-cre)1Mnt/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0008817 hematoma "an abnormal localized accumulation of clotted or partially clotted blood in an organ or a soft tissue space as a result of localized hemorrhage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: involves: C57BL/6NSlc

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita

Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
Genetic Background: B6.Cg-Ins2Akita Bdkrb2tm1Jfh

 MP:0008963 increased carbon dioxide production "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

 MP:0009112 abnormal pancreatic beta cell mass "anomaly in the total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpbtm1.1Maka/Cebpbtm1.1Maka,Ins2Akita/Ins2Akita,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NSlc * CBA/J

 MP:0009113 increased pancreatic beta cell mass "greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntrk2tm1Ddg/Ntrk2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009114 decreased pancreatic beta cell mass "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: involves: C57BL/6NSlc

 MP:0009171 enlarged pancreatic islets "increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Il10tm1Roer/Il10tm1Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: C57BL/6-Ins2Akita

Allelic Composition: Ero1lbGt(P077G11)Wrst/Ero1lb+,Ins2Akita/Ins2+
Genetic Background: involves: 129S2/SvPas * C57BL/6NSlc

 MP:0009174 absent pancreatic beta cells "absence of the cells of the pancreas that secrete insulin" [MESH:A03.734.414.131]
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Allelic Composition: Il10tm1Roer/Il10tm1Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009176 increased pancreatic alpha cell number "increase in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
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Allelic Composition: Ins2C95S/Ins2+
Genetic Background: C3HeB/FeJ-Ins2C95S

 MP:0009177 decreased pancreatic alpha cell number "reduction in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
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Allelic Composition: Il10tm1Roer/Il10tm1Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009254 disorganized pancreatic islets "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2C95S/Ins2+
Genetic Background: C3HeB/FeJ-Ins2C95S

 MP:0009255 degranulated pancreatic beta cells "insulin-secreting cells of the pancreas do not contain vesicles containing insulin" [MGI:acv "Alicia Valenzuela, Genetic Resources Curator"]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009488 pancreatic islet cell apoptosis "change in the timing or the number of pancreatic islet cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpbtm1.1Maka/Cebpbtm1.1Maka,Ins2Akita/Ins2Akita,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NSlc * CBA/J

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Il10tm1Roer/Il10tm1Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ins2Akita/Ins2Akita,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1.1Mnt/Ins2tm1.1Mnt
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0011320 abnormal glomerular capillary morphology "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]
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Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: C.B6N-Ins2Akita

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0011339 abnormal glomerular mesangium morphology "any structural anomaly of the inner layer of the glomerulus within the basement membrane surrounding the glomerular capillaries that contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: C.B6N-Ins2Akita

Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C.B6N-Ins2Akita

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
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Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: C.B6N-Ins2Akita

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0011425 abnormal kidney interstitium morphology "any structural anomaly of the kidney region located between the nephrons, ureteric epithelia (ureteric tips, trunk and collecting duct system) and renal vasculature, and composed of renal support cells, including fibroblasts and macrophages, and mesenchymal stroma or interstitial cells; the renal vasculature lies within the renal interstitium but is not a part of it; various conditions can lead to scarring (fibrosis) and congestion of this area, which can cause kidney dysfunction and failure" [MGI:anna]
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Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: C.B6N-Ins2Akita

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0011430 mesangiolysis "an injurious glomerular process that affects primarily the mesangium, starting with loosening and detachment of its matrix and progressing to dissolution/attenuation with degeneration of mesangial cells; mesangial cells may show only edema and vacuolization, or may undergo severe degeneration and necrosis" [MGI:anna]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0011638 abnormal mitochondrial chromosome morphology "any structrual anomaly of the chromosome found in the mitochondrion of a eukaryotic cell" [GO:0000262]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
Genetic Background: B6.Cg-Ins2Akita Bdkrb2tm1Jfh

 MP:0011819 increased pancreatic beta cell proliferation "increase in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

Allelic Composition: Ins2Akita/Ins2+
Genetic Background: involves: C57BL/6NSlc

Allelic Composition: Ins2Akita/Ins2+,Rnf213tm1.1Akoi/Rnf213tm1.1Akoi
Genetic Background: involves: C57BL/6N * C57BL/6NSlc

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita

 MP:0014109 increased pancreatic alpha cell proliferation "increase in the ability of the glucagon-producing cells of the islets of Langerhans in the endocrine pancreas to undergo expansion by cell division" [MGI:Anna]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0014121 increased pancreatic islet cell apoptosis "increase in the number of pancreatic islet cells undergoing programmed cell death" [MGI:Anna]
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Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: involves: C57BL/6NSlc

 MP:0014122 decreased pancreatic islet cell apoptosis "decrease in the number of pancreatic islet cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0014143 decreased body fat mass "decreased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

 MP:0020518 renal glomerular protein deposits "any anomalous accumulation of protein in the renal glomerulus" [HP:0030949]
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Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: C.B6N-Ins2Akita

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C57BL/6-Ins2Akita/J

 MP:0030016 increased adipocyte glucose uptake "increased ability of adipocytes to take in glucose" [MGI:anna]
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Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

 MP:0030017 decreased adipocyte glucose uptake "reduced ability of adipocytes to take in glucose" [MGI:anna]
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Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

 MP:0030022 decreased muscle cell glucose uptake "reduced ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

 MP:0030589 increased pancreatic alpha cell mass "greater total physical bulk or volume of a pancreatic alpha cell compared to the normal state" [MGI:anna]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000215 Ins2 / P01326 / Insulin-2 Insulin-2 B chain Insulin-2 A chain / INS* / P01308* / insulin*  / complex / reaction
 ENSMUSG00000035804 Ins1 / P01325 / Insulin-1 Insulin-1 B chain Insulin-1 A chain / INS* / P01308* / insulin*  / complex / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex / reaction
 ENSMUSG00000005534 Insr / P15208 / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta / P06213* / insulin receptor*  / complex / reaction
 ENSMUSG00000021831 Ero1l / Q8R180 / ERO1-like protein alpha / ERO1A* / Q96HE7* / endoplasmic reticulum oxidoreductase 1 alpha*  / reaction
 ENSMUSG00000038894 Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*  / complex / reaction
 ENSMUSG00000055980 Irs1 / insulin receptor substrate 1 / P35568*  / complex / reaction
 ENSMUSG00000020176 Grb10 / Q60760 / Growth factor receptor-bound protein 10 / Q13322*  / complex / reaction






 

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