ENSMUSG00000000320


Mus musculus

Features
Gene ID: ENSMUSG00000000320
  
Biological name :Alox12
  
Synonyms : Alox12 / arachidonate 12-lipoxygenase / P39655
  
Possible biological names infered from orthology : arachidonate 12-lipoxygenase, 12S type / P18054
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 70241457
Gene end: 70255353
  
Corresponding Affymetrix probe sets: 10387821 (MoGene1.0st)   1422699_at (Mouse Genome 430 2.0 Array)   1422700_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000329
Ensembl peptide - ENSMUSP00000104214
NCBI entrez gene - 11684     See in Manteia.
MGI - MGI:87998
RefSeq - XM_011248678
RefSeq - NM_001331118
RefSeq - NM_007440
RefSeq - XM_011248677
RefSeq Peptide - NP_031466
RefSeq Peptide - NP_001318047
swissprot - P39655
swissprot - Q8C587
swissprot - A2CF85
Ensembl - ENSMUSG00000000320
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-17e16.9ENSDARG00000073781Danio rerio
 ALOX12ENSG00000108839Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P55249 / Alox12e / arachidonate lipoxygenase, epidermalENSMUSG0000001890760
Alox15 / P39654 / Arachidonate 15-lipoxygenase / P16050*ENSMUSG0000001892458
Alox5 / P48999 / Arachidonate 5-lipoxygenase / P09917*ENSMUSG0000002570141
Alox8 / O35936 / Arachidonate 8S-lipoxygenase / O15296* / ALOX15B* / arachidonate 15-lipoxygenase, type B*ENSMUSG0000002089139
Aloxe3 / Q9WV07 / arachidonate lipoxygenase 3 / Q9BYJ1*ENSMUSG0000002089238
O70582 / Alox12b / Arachidonate 12-lipoxygenase, 12R-type / O75342*ENSMUSG0000003280737


Protein motifs (from Interpro)
Interpro ID Name
 IPR000907  Lipoxygenase
 IPR001024  PLAT/LH2 domain
 IPR001885  Lipoxygenase, mammalian
 IPR013819  Lipoxygenase, C-terminal
 IPR020833  Lipoxygenase, iron binding site
 IPR020834  Lipoxygenase, conserved site
 IPR036226  Lipoxigenase, C-terminal domain superfamily
 IPR036392  PLAT/LH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010656 negative regulation of muscle cell apoptotic process ISO
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0019369 arachidonic acid metabolic process ISO
 biological_processGO:0019372 lipoxygenase pathway ISO
 biological_processGO:0019395 fatty acid oxidation ISO
 biological_processGO:0030307 positive regulation of cell growth ISO
 biological_processGO:0030335 positive regulation of cell migration ISO
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043651 linoleic acid metabolic process ISS
 biological_processGO:0045603 positive regulation of endothelial cell differentiation IEA
 biological_processGO:0045766 positive regulation of angiogenesis ISO
 biological_processGO:0045785 positive regulation of cell adhesion ISO
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051122 hepoxilin biosynthetic process ISS
 biological_processGO:0051901 positive regulation of mitochondrial depolarization IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061436 establishment of skin barrier IMP
 biological_processGO:0071396 cellular response to lipid IEA
 biological_processGO:0090331 negative regulation of platelet aggregation IMP
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 biological_processGO:1901751 leukotriene A4 metabolic process ISS
 biological_processGO:2001303 lipoxin A4 biosynthetic process ISO
 biological_processGO:2001306 lipoxin B4 biosynthetic process ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0042383 sarcolemma IEA
 molecular_functionGO:0004052 arachidonate 12-lipoxygenase activity ISS
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016165 linoleate 13S-lipoxygenase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047977 hepoxilin-epoxide hydrolase activity ISS
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of Hepoxilins (HX) and Trioxilins (TrX)
Synthesis of Lipoxins (LX)
Synthesis of 12-eicosatetraenoic acid derivatives
Biosynthesis of DHA-derived SPMs
Biosynthesis of DPAn-6 SPMs
Biosynthesis of DPAn-3-derived maresins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0009586 increased platelet aggregation "increase in the ability of one platelet to one or more other platelets via adhesion molecules" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0020408 altered susceptibility to induced thrombosis "any anomaly in the formation of thrombi following mechanical or chemical stimulation of thrombosis" [PMID:16614756, PMID:9262402]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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