ENSMUSG00000000386


Mus musculus

Features
Gene ID: ENSMUSG00000000386
  
Biological name :Mx1
  
Synonyms : Mx1 / MX dynamin-like GTPase 1
  
Possible biological names infered from orthology : P20591
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C4
Gene start: 97447035
Gene end: 97462907
  
Corresponding Affymetrix probe sets: 10441233 (MoGene1.0st)   1451905_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138813
Ensembl peptide - ENSMUSP00000023655
Ensembl peptide - ENSMUSP00000109397
Ensembl peptide - ENSMUSP00000114709
Ensembl peptide - ENSMUSP00000138532
MGI - MGI:97243
swissprot - V9GWS9
swissprot - E9Q0J3
swissprot - Q3UD61
swissprot - S4R279
swissprot - D3YV39
Ensembl - ENSMUSG00000000386
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mxcENSDARG00000024789Danio rerio
 mxeENSDARG00000014427Danio rerio
 MX1ENSGALG00000016142Gallus gallus
 MX1ENSG00000157601Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mx2 / Q9WVP9 / Mus musculus MX dynamin-like GTPase 2 (Mx2), transcript variant 1, mRNA. / MX1* / P20591* / MX dynamin like GTPase 1*ENSMUSG0000002334176
Dnm2 / P39054 / Mus musculus dynamin 2 (Dnm2), transcript variant 5, mRNA. / P50570* / dynamin 2*ENSMUSG0000003333532
Dnm3 / Q8BZ98 / Dynamin-3 / Q9UQ16*ENSMUSG0000004026532
Dnm1 / P39053 / Dynamin-1 / Q05193*ENSMUSG0000002682531
Dnm1l / Q8K1M6 / Dynamin-1-like protein / O00429* / dynamin 1 like*ENSMUSG0000002278929


Protein motifs (from Interpro)
Interpro ID Name
 IPR000375  Dynamin central domain
 IPR001401  Dynamin, GTPase domain
 IPR003130  Dynamin GTPase effector
 IPR019762  Dynamin, GTPase region, conserved site
 IPR020850  GTPase effector domain
 IPR022812  Dynamin superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030381  Dynamin-type guanine nucleotide-binding (G) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001793 altered susceptibility to infection "a change in the likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mx1s1/Mx1s1
Genetic Background: BALB/c

Allelic Composition: Mx1s1/Mx1s1
Genetic Background: C57BL/6

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mfge8tm1Mcu/Mfge8tm1Mcu
Genetic Background: involves: 129X1/SvJ * C57BL/6NCr

Allelic Composition: Mx1s1/Mx1s1,Tg(Hmgcr-MX1)LStae/?
Genetic Background: involves: C57BL/6 * SJL

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Epb41l5lulu/Epb41l5lulu
Genetic Background: involves: C57BL/6J

Allelic Composition: Mx1s1/Mx1s1
Genetic Background: BALB/c

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Mta1tm1a(EUCOMM)Wtsi/Mta1tm1a(EUCOMM)Wtsi
Genetic Background: 129S/SvEvBrd-Mta1tm1a(EUCOMM)Wtsi/WtsiH

 MP:0008244 abnormal peritoneal macrophage morphology "any structural anomaly of a mononuclear phagocyte that develops from bone marrow precursors but is resident in the peritoneum" [CL:0000581, MESH:A.11.329.372.630]
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Allelic Composition: Mx1s1/Mx1s1
Genetic Background: C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Epb41l5lulu/Epb41l5lulu
Genetic Background: involves: C57BL/6J

Allelic Composition: Mx1s1/Mx1s1
Genetic Background: BALB/c

Allelic Composition: Mx1s1/Mx1s1
Genetic Background: C3H

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mx1s1/Mx1s1
Genetic Background: BALB/c

Allelic Composition: Mx1r/Mx1r
Genetic Background: C.A2G-Mx1r

Allelic Composition: Mx1r/Mx1r
Genetic Background: A2G

Allelic Composition: Mx1s1/Mx1s1,Tg(Hmgcr-MX1)LStae/?
Genetic Background: involves: C57BL/6 * SJL

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mx1s1/Mx1s1
Genetic Background: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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