ENSMUSG00000040265


Mus musculus

Features
Gene ID: ENSMUSG00000040265
  
Biological name :Dnm3
  
Synonyms : Dnm3 / Dynamin-3 / Q8BZ98
  
Possible biological names infered from orthology : Q9UQ16
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H2.1
Gene start: 161982453
Gene end: 162478034
  
Corresponding Affymetrix probe sets: 10359480 (MoGene1.0st)   1425403_at (Mouse Genome 430 2.0 Array)   1436624_at (Mouse Genome 430 2.0 Array)   1436875_at (Mouse Genome 430 2.0 Array)   1438801_at (Mouse Genome 430 2.0 Array)   1446265_at (Mouse Genome 430 2.0 Array)   1446694_at (Mouse Genome 430 2.0 Array)   1457405_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125356
Ensembl peptide - ENSMUSP00000064538
Ensembl peptide - ENSMUSP00000083241
Ensembl peptide - ENSMUSP00000124593
NCBI entrez gene - 103967     See in Manteia.
MGI - MGI:1341299
RefSeq - XM_006496605
RefSeq - NM_001038619
RefSeq - NM_172646
RefSeq - XM_006496601
RefSeq - XM_006496602
RefSeq - XM_006496603
RefSeq - XM_006496604
RefSeq Peptide - NP_001033708
RefSeq Peptide - NP_766234
swissprot - F2Z460
swissprot - E9QLL2
swissprot - Q8BZ98
swissprot - E0CXZ8
Ensembl - ENSMUSG00000040265
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000033244Gallus gallus
 ENSGALG00000003164Gallus gallus
 DNM3ENSG00000197959Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dnm1 / P39053 / Dynamin-1 / Q05193*ENSMUSG0000002682581
Dnm2 / P39054 / Mus musculus dynamin 2 (Dnm2), transcript variant 5, mRNA. / P50570* / dynamin 2*ENSMUSG0000003333580
Dnm1l / Q8K1M6 / Dynamin-1-like protein / O00429* / dynamin 1 like*ENSMUSG0000002278934
Mx2 / Q9WVP9 / Mus musculus MX dynamin-like GTPase 2 (Mx2), transcript variant 1, mRNA. / MX1* / P20591* / MX dynamin like GTPase 1*ENSMUSG0000002334122
Mx1 / MX dynamin-like GTPase 1 / P20591*ENSMUSG0000000038615


Protein motifs (from Interpro)
Interpro ID Name
 IPR000375  Dynamin central domain
 IPR001401  Dynamin, GTPase domain
 IPR001849  Pleckstrin homology domain
 IPR003130  Dynamin GTPase effector
 IPR011993  PH-like domain superfamily
 IPR019762  Dynamin, GTPase region, conserved site
 IPR020850  GTPase effector domain
 IPR022812  Dynamin superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030381  Dynamin-type guanine nucleotide-binding (G) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000266 mitochondrial fission IBA
 biological_processGO:0003374 dynamin family protein polymerization involved in mitochondrial fission IBA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane IGI
 biological_processGO:0051491 positive regulation of filopodium assembly IEA
 biological_processGO:0061001 regulation of dendritic spine morphogenesis IEA
 biological_processGO:0061002 negative regulation of dendritic spine morphogenesis IEA
 biological_processGO:0061025 membrane fusion IBA
 biological_processGO:0098884 postsynaptic neurotransmitter receptor internalization IEA
 biological_processGO:1903423 positive regulation of synaptic vesicle recycling IEA
 cellular_componentGO:0001917 photoreceptor inner segment IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0031966 mitochondrial membrane IBA
 cellular_componentGO:0043083 synaptic cleft IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0044327 dendritic spine head IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0061828 apical tubulobulbar complex IEA
 cellular_componentGO:0061829 basal tubulobulbar complex IEA
 cellular_componentGO:0098844 postsynaptic endocytic zone membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0008017 microtubule binding IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0031798 type 1 metabotropic glutamate receptor binding IEA
 molecular_functionGO:0031802 type 5 metabotropic glutamate receptor binding IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0050998 nitric-oxide synthase binding IEA


Pathways (from Reactome)
Pathway description
Toll Like Receptor 4 (TLR4) Cascade
MHC class II antigen presentation
Recycling pathway of L1
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Dnm1tm1Pdc/Dnm1tm1Pdc,Dnm3tm1.2Pdc/Dnm3tm1.2Pdc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Dnm1tm1Pdc/Dnm1tm1Pdc,Dnm3tm1.2Pdc/Dnm3tm1.2Pdc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adamts5tm2.2Lex/Adamts5tm2.2Lex
Genetic Background: B6.129S5-Adamts5tm2.2Lex

 MP:0003491 abnormal voluntary movement "anomalies in coordinated movements executed with a purpose and can be improved by learning and/or experience" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Dnm1tm1Pdc/Dnm1tm1Pdc,Dnm3tm1.2Pdc/Dnm3tm1.2Pdc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnm1tm1Pdc/Dnm1tm1Pdc,Dnm3tm1.2Pdc/Dnm3tm1.2Pdc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0004769 abnormal synaptic vesicle morphology "any structural anomaly of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnm1tm1Pdc/Dnm1tm1Pdc,Dnm3tm1.2Pdc/Dnm3tm1.2Pdc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0004770 abnormal synaptic vesicle recycling "any functional anomaly in the process of the fusion of a subpopulation of synaptic vesicles with the cell membrane at the active zone, the subsequent endocytosis back from the plasma membrane, the refilling of these vesicles with neurotransmitters, and trafficking back to the active zone pool of vesicles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnm1tm1Pdc/Dnm1tm1Pdc,Dnm3tm1.2Pdc/Dnm3tm1.2Pdc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnm1tm1Pdc/Dnm1tm1Pdc,Dnm3tm1.2Pdc/Dnm3tm1.2Pdc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnm1tm1Pdc/Dnm1tm1Pdc,Dnm3tm1.2Pdc/Dnm3tm1.2Pdc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Dnm1tm1Pdc/Dnm1tm1Pdc,Dnm3tm1.2Pdc/Dnm3tm1.2Pdc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0011270 decreased excitatory postsynaptic current amplitude "reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
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Allelic Composition: Dnm1tm1Pdc/Dnm1tm1Pdc,Dnm3tm1.2Pdc/Dnm3tm1.2Pdc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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