ENSMUSG00000000628


Mus musculus

Features
Gene ID: ENSMUSG00000000628
  
Biological name :Hk2
  
Synonyms : Hexokinase-2 / Hk2 / O08528
  
Possible biological names infered from orthology : P52789
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: C3
Gene start: 82725025
Gene end: 82774454
  
Corresponding Affymetrix probe sets: 10545588 (MoGene1.0st)   1422612_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000642
Ensembl peptide - ENSMUSP00000128572
Ensembl peptide - ENSMUSP00000125986
NCBI entrez gene - 15277     See in Manteia.
MGI - MGI:1315197
RefSeq - NM_013820
RefSeq - XM_017321401
RefSeq Peptide - NP_038848
swissprot - E9Q9M6
swissprot - O08528
swissprot - E9Q5B5
Ensembl - ENSMUSG00000000628
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hk2ENSDARG00000101482Danio rerio
 HK2ENSG00000159399Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hk1 / P17710 / Hexokinase-1 / P19367*ENSMUSG0000003701271
Hkdc1 / Q91W97 / Putative hexokinase HKDC1 / Q2TB90* / hexokinase domain containing 1*ENSMUSG0000002008068
Hk3 / Q3TRM8 / Hexokinase-3 / P52790*ENSMUSG0000002587755
Gck / P52792 / Glucokinase / P35557*ENSMUSG0000004179827


Protein motifs (from Interpro)
Interpro ID Name
 IPR001312  Hexokinase
 IPR019807  Hexokinase, binding site
 IPR022672  Hexokinase, N-terminal
 IPR022673  Hexokinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001678 cellular glucose homeostasis IEA
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006006 glucose metabolic process IMP
 biological_processGO:0006096 glycolytic process IEA
 biological_processGO:0007595 lactation IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008637 apoptotic mitochondrial changes IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019318 hexose metabolic process IEA
 biological_processGO:0035795 negative regulation of mitochondrial membrane permeability IMP
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0046324 regulation of glucose import IMP
 biological_processGO:0046835 carbohydrate phosphorylation IEA
 biological_processGO:0051156 glucose 6-phosphate metabolic process IEA
 biological_processGO:0072655 establishment of protein localization to mitochondrion IEA
 biological_processGO:0072656 maintenance of protein location in mitochondrion IEA
 biological_processGO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IMP
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004340 glucokinase activity IBA
 molecular_functionGO:0004396 hexokinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005536 glucose binding IEA
 molecular_functionGO:0008865 fructokinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016773 phosphotransferase activity, alcohol group as acceptor IEA
 molecular_functionGO:0019158 mannokinase activity IBA


Pathways (from Reactome)
Pathway description
Glycolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tex101tm1Qzh/Tex101tm1Qzh
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR)

 MP:0000874 irregular external granule cell layer "uneven thickness of the transient layer of the cerebellar cortex which is composed of dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tex101tm1Qzh/Tex101tm1Qzh
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR)

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Hk2tm1.1Uku/Hk2tm1.1Uku,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Hk2tm1.1Uku/Hk2+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata3jal/Gata3+
Genetic Background: C3H/HeJ-Gata3jal/J

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Hk2tm1.1Uku/Hk2tm1.1Uku,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tex101tm1Qzh/Tex101tm1Qzh
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR)

Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Hk2tm1.1Uku/Hk2tm1.1Uku,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0006283 medulloblastoma "a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin " [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Hk2tm1.1Uku/Hk2tm1.1Uku,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Hk2tm1.1Uku/Hk2+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Hk2tm1.1Uku/Hk2tm1.1Uku,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0009977 abnormal cerebellar granule cell migration "defective or impaired movement of cerebellar granule cell neurons from the germinal zone into the granule cell layer of the cerebellum during development of the cerebellar cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tex101tm1Qzh/Tex101tm1Qzh
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR)

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Hk2tm1.1Uku/Hk2tm1.1Uku,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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