ENSMUSG00000020080


Mus musculus
activityHkdc1hexokinasebindingglucoseprocessmetaboliccarbohydratephosphorylationsiten-terminalc-terminalcellularhomeostasisglycolytichexose-phosphatemitochondrioncytosolnucleotideglucokinaseatpfructokinasekinasetransferasephosphotransferasealcoholgroupacceptormannokinaseimpaired

Features
Gene ID: ENSMUSG00000020080
  
Biological name :Hkdc1
  
Synonyms : Hkdc1 / Putative hexokinase HKDC1 / Q91W97
  
Possible biological names infered from orthology : hexokinase domain containing 1 / Q2TB90
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B4
Gene start: 62383137
Gene end: 62422491
  
Corresponding Affymetrix probe sets: 10369567 (MoGene1.0st)   1425900_at (Mouse Genome 430 2.0 Array)   1459421_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020277
NCBI entrez gene - 216019     See in Manteia.
MGI - MGI:2384910
RefSeq - XM_011243398
RefSeq - NM_145419
RefSeq - XM_006513473
RefSeq - XM_011243397
RefSeq Peptide - NP_663394
swissprot - Q91W97
Ensembl - ENSMUSG00000020080
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hkdc1ENSDARG00000038703Danio rerio
 HKDC1ENSGALG00000021039Gallus gallus
 HKDC1ENSG00000156510Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hk1 / P17710 / Hexokinase-1 / P19367*ENSMUSG0000003701270
Hk2 / O08528 / Hexokinase-2 / P52789*ENSMUSG0000000062868
Hk3 / Q3TRM8 / Hexokinase-3 / P52790*ENSMUSG0000002587752
Gck / P52792 / Glucokinase / P35557*ENSMUSG0000004179824


Protein motifs (from Interpro)
Interpro ID Name
 IPR001312  Hexokinase
 IPR019807  Hexokinase, binding site
 IPR022672  Hexokinase, N-terminal
 IPR022673  Hexokinase, C-terminal


Gene Ontology (GO)
regulation of biological qualityprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcatabolic processcellular metabolic processsmall molecule metabolic processregulation of biological qualityprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcatabolic processcellular metabolic processsmall molecule metabolic processregulation of biological qualityprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcatabolic processcellular metabolic processsmall molecule metabolic processregulation of biological qualityprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcatabolic processcellular metabolic processsmall molecule metabolic processregulation of biological qualityprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcatabolic processcellular metabolic processsmall molecule metabolic processregulation of biological qualityprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcatabolic processcellular metabolic processsmall molecule metabolic processregulation of biological qualityprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcatabolic processcellular metabolic processsmall molecule metabolic processregulation of biological qualityprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcatabolic processcellular metabolic processsmall molecule metabolic processregulation of biological qualityprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcatabolic processcellular metabolic processsmall molecule metabolic processregulation of biological qualityprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcatabolic processcellular metabolic processsmall molecule metabolic processregulation of bioregulation of biological qualityprimary metabolicprimary metabolic processorganic substanceorganic substance metabolic processnitrogen compoundnitrogen compound metabolic processbiosynthetic procbiosynthetic processcatabolic processcatabolic processcellular metabolicellular metabolic processsmall molecule mesmall molecule metabolic process
organic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingtransferase activityion bindingcarbohydrate derivative bindingdrug bindingcarbohydrate bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingtransferase activityion bindingcarbohydrate derivative bindingdrug bindingcarbohydrate bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingtransferase activityion bindingcarbohydrate derivative bindingdrug bindingcarbohydrate bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingtransferase activityion bindingcarbohydrate derivative bindingdrug bindingcarbohydrate bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingtransferase activityion bindingcarbohydrate derivative bindingdrug bindingcarbohydrate bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingtransferase activityion bindingcarbohydrate derivative bindingdrug bindingcarbohydrate bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingtransferase activityion bindingcarbohydrate derivative bindingdrug bindingcarbohydrate bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingtransferase activityion bindingcarbohydrate derivative bindingdrug bindingcarbohydrate bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingtransferase activityion bindingcarbohydrate derivative bindingdrug bindingcarbohydrate bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingtransferase activityion bindingcarbohydrate derivative bindingdrug bindingcarbohydrate bindingorganic cyclic coorganic cyclic compound bindingheterocyclic compheterocyclic compound bindingsmall molecule bismall molecule bindingtransferase activtransferase activityion bindingion bindingcarbohydrate dericarbohydrate derivative bindingdrug bindingdrug bindingcarbohydrate bindcarbohydrate binding
cellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellcellorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0001678 cellular glucose homeostasis IBA
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006096 glycolytic process IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019318 hexose metabolic process IEA
 biological_processGO:0046835 carbohydrate phosphorylation IEA
 biological_processGO:0051156 glucose 6-phosphate metabolic process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004340 glucokinase activity IBA
 molecular_functionGO:0004396 hexokinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005536 glucose binding IEA
 molecular_functionGO:0008865 fructokinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016773 phosphotransferase activity, alcohol group as acceptor IEA
 molecular_functionGO:0019158 mannokinase activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
homeostasis/metabolism phenotypeliver/biliary system phenotypemortality/aginghomeostasis/metabolism phenotypeliver/biliary system phenotypemortality/aginghomeostasis/metabolism phenotypeliver/biliary system phenotypemortality/aginghomeostasis/metabolism phenotypeliver/biliary system phenotypemortality/aginghomeostasis/metabolism phenotypeliver/biliary system phenotypemortality/aginghomeostasis/metabolism phenotypeliver/biliary system phenotypemortality/aginghomeostasis/metabolism phenotypeliver/biliary system phenotypemortality/aginghomeostasis/metabolism phenotypeliver/biliary system phenotypemortality/aginghomeostasis/metabolism phenotypeliver/biliary system phenotypemortality/aginghomeostasis/metabolism phenotypeliver/biliary system phenotypemortality/aginghomeostasis/metabolism phenotypehomeostasis/metabolism phenotypeliver/biliary system phenotypeliver/biliary system phenotypemortality/agingmortality/aging
IDPhenotypeDefinition Genetic BG
 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Smarcd1tm1.1Jddl/Smarcd1tm1.1Jddl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Smarcd1tm1.1Jddl/Smarcd1tm1.1Jddl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Smarcd1tm1.1Jddl/Smarcd1tm1.1Jddl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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