ENSMUSG00000001655


Mus musculus

Features
Gene ID: ENSMUSG00000001655
  
Biological name :Hoxc13
  
Synonyms : Homeobox protein Hox-C13 / Hoxc13 / P50207
  
Possible biological names infered from orthology : homeobox C13 / P31276
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F3
Gene start: 102921103
Gene end: 102928814
  
Corresponding Affymetrix probe sets: 10427268 (MoGene1.0st)   1425874_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001700
NCBI entrez gene - 15422     See in Manteia.
MGI - MGI:99560
RefSeq - NM_010464
RefSeq Peptide - NP_034594
swissprot - P50207
Ensembl - ENSMUSG00000001655
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hoxc13aENSDARG00000070353Danio rerio
 Q6JIY4ENSDARG00000113877Danio rerio
 HOXC13ENSGALG00000036082Gallus gallus
 HOXC13ENSG00000123364Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hoxa13 / homeobox protein Hox-A13 / P31271* / homeobox A13*ENSMUSG0000003820351
Hoxd13 / P70217 / Homeobox protein Hox-D13 / P35453* / homeobox D13*ENSMUSG0000000181945
Hoxb13 / P70321 / Homeobox protein Hox-B13 / Q92826* / homeobox B13*ENSMUSG0000004960442
Hoxc10 / P31257 / Homeobox protein Hox-C10 / Q9NYD6* / homeobox C10*ENSMUSG0000002248420
Hoxc11 / P31313 / Homeobox protein Hox-C11 / O43248* / homeobox C11*ENSMUSG0000000165618
Hoxa9 / P09631 / Homeobox protein Hox-A9 / P31269* / AC004080.3* / homeobox A9*ENSMUSG0000003822718
Hoxd11 / homeobox D11 / P31277*ENSMUSG0000004249918
Hoxa10 / P31310 / Homeobox protein Hox-A10 / P31260* / homeobox A10*ENSMUSG0000000093817
Hoxa11 / P31311 / Homeobox protein Hox-A11 / P31270* / homeobox A11*ENSMUSG0000003821017
Hoxd10 / P28359 / Homeobox protein Hox-D10 / P28358* / homeobox D10*ENSMUSG0000005036817
Hoxd12 / P23812 / Homeobox protein Hox-D12 / P35452* / homeobox D12*ENSMUSG0000000182316
Hoxb9 / P20615 / Homeobox protein Hox-B9 / P17482* / homeobox B9*ENSMUSG0000002087516
Hoxc9 / P09633 / Homeobox protein Hox-C9 / P31274* / homeobox C9*ENSMUSG0000003613916
Hoxd9 / P28357 / Homeobox protein Hox-D9 / P28356* / homeobox D9*ENSMUSG0000004334216
Hoxc12 / Q8K5B8 / Homeobox protein Hox-C12 / P31275* / homeobox C12*ENSMUSG0000005032815


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR022067  Homeobox protein Hox1A3 N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001942 hair follicle development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009653 anatomical structure morphogenesis IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0035878 nail development IMP
 biological_processGO:0043587 tongue morphogenesis IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Hoxa1tm1Mrc/Hoxa1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Hoxc13tm3Mrc/Hoxc13tm3Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Hoxc13tm3.1Mrc/Hoxc13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000418 patchy hair "uneven spots of hair growth on the body" [J:26975]
Show

Allelic Composition: Hoxc13tm3Mrc/Hoxc13tm3Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Hoxc13tm3.1Mrc/Hoxc13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000425 loss of cilia "inability to retain the eyelashes " [J:45400]
Show

Allelic Composition: Hoxa1tm1Mrc/Hoxa1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000580 deformed nails "atypical shape or size of the nails" [J:45400]
Show

Allelic Composition: Hoxa1tm1Mrc/Hoxa1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxc13tm3Mrc/Hoxc13tm3Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Hoxc13tm3.1Mrc/Hoxc13tm3.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Hoxa1tm1Mrc/Hoxa1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000763 abnormal filiform papillae "malformed keratinized projections on the dorsal surface of the tongue" [J:45400]
Show

Allelic Composition: Hoxa1tm1Mrc/Hoxa1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxc13tm3Mrc/Hoxc13tm3Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Hoxc13tm3.1Mrc/Hoxc13tm3.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000764 abnormal tongue epithelium morphology "malformation of the epithelial layer of the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Hoxa1tm1Mrc/Hoxa1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Hoxa1tm1Mrc/Hoxa1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001284 absent vibrissae "missing whiskers" [J:18378]
Show

Allelic Composition: Hoxa1tm1Mrc/Hoxa1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa1tm1Mrc/Hoxa1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxc13tm3Mrc/Hoxc13tm3Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Hoxc13tm3.1Mrc/Hoxc13tm3.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa1tm1Mrc/Hoxa1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxc13tm1Mrc/Hoxc13+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxc13tm2Mrc/Hoxc13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003848 brittle hair "hair is susceptible to breakage " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa1tm1Mrc/Hoxa1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004614 caudal vertebral transformation "homeotic transformation of any caudal vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa1tm1Mrc/Hoxa1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxc13tm1Mrc/Hoxc13+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxc13tm2Mrc/Hoxc13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010233 hairless tail "the tail is devoid of hair" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa1tm1Mrc/Hoxa1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Hoxa1tm1Mrc/Hoxa1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr