ENSMUSG00000050368


Mus musculus

Features
Gene ID: ENSMUSG00000050368
  
Biological name :Hoxd10
  
Synonyms : Homeobox protein Hox-D10 / Hoxd10 / P28359
  
Possible biological names infered from orthology : homeobox D10 / P28358
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C3
Gene start: 74691924
Gene end: 74695105
  
Corresponding Affymetrix probe sets: 10472958 (MoGene1.0st)   1418606_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000062412
NCBI entrez gene - 15430     See in Manteia.
MGI - MGI:96202
RefSeq - NM_013554
RefSeq - XM_006498789
RefSeq Peptide - NP_038582
swissprot - P28359
Ensembl - ENSMUSG00000050368
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q90469ENSDARG00000057859Danio rerio
 HOXD10ENSGALG00000009270Gallus gallus
 HOXD10ENSG00000128710Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hoxa10 / P31310 / Homeobox protein Hox-A10 / P31260* / homeobox A10*ENSMUSG0000000093851
Hoxc10 / P31257 / Homeobox protein Hox-C10 / Q9NYD6* / homeobox C10*ENSMUSG0000002248444
Hoxb9 / P20615 / Homeobox protein Hox-B9 / P17482* / homeobox B9*ENSMUSG0000002087526
Hoxa9 / P09631 / Homeobox protein Hox-A9 / P31269* / AC004080.3* / homeobox A9*ENSMUSG0000003822725
Hoxc9 / P09633 / Homeobox protein Hox-C9 / P31274* / homeobox C9*ENSMUSG0000003613924
Hoxd9 / P28357 / Homeobox protein Hox-D9 / P28356* / homeobox D9*ENSMUSG0000004334224
Hoxa11 / P31311 / Homeobox protein Hox-A11 / P31270* / homeobox A11*ENSMUSG0000003821021
Hoxd11 / homeobox D11 / P31277*ENSMUSG0000004249921
Hoxc11 / P31313 / Homeobox protein Hox-C11 / O43248* / homeobox C11*ENSMUSG0000000165619
Hoxd13 / P70217 / Homeobox protein Hox-D13 / P35453* / homeobox D13*ENSMUSG0000000181917
Hoxc12 / Q8K5B8 / Homeobox protein Hox-C12 / P31275* / homeobox C12*ENSMUSG0000005032817
Hoxc13 / P50207 / Homeobox protein Hox-C13 / P31276* / homeobox C13*ENSMUSG0000000165516
Hoxd12 / P23812 / Homeobox protein Hox-D12 / P35452* / homeobox D12*ENSMUSG0000000182316
Hoxa13 / homeobox protein Hox-A13 / P31271* / homeobox A13*ENSMUSG0000003820316
Hoxb13 / P70321 / Homeobox protein Hox-B13 / Q92826* / homeobox B13*ENSMUSG0000004960414


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007338 single fertilization IGI
 biological_processGO:0007519 skeletal muscle tissue development IGI
 biological_processGO:0008344 adult locomotory behavior IGI
 biological_processGO:0009952 anterior/posterior pattern specification IGI
 biological_processGO:0009954 proximal/distal pattern formation IGI
 biological_processGO:0010468 regulation of gene expression IGI
 biological_processGO:0021520 spinal cord motor neuron cell fate specification IGI
 biological_processGO:0030326 embryonic limb morphogenesis IGI
 biological_processGO:0035136 forelimb morphogenesis IGI
 biological_processGO:0035137 hindlimb morphogenesis IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048704 embryonic skeletal system morphogenesis IGI
 biological_processGO:0048935 peripheral nervous system neuron development IGI
 biological_processGO:0050905 neuromuscular process IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Hoxa10tm1Mrc/Hoxa10tm1Mrc,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxa10tm1Mrc/Hoxa10+,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
Show

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
Show

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001077 abnormal spinal nerve morphology "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001388 abnormal stationary movement "altered ability or inability to change body posture or shift a body part" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

Allelic Composition: Hoxd10tm1Mrc/Hoxd10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il4ratm1Sz/Il4ratm1Sz
Genetic Background: BALB/c-Il4ratm1Sz

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

Allelic Composition: Hoxd10tm1Mrc/Hoxd10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
Show

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002823 abnormal rib development "anomalous formation of the bones forming the bony wall of the chest" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84754]
Show

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003049 abnormal lumbar vertebrae morphology "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hoxa10tm1Mrc/Hoxa10tm1Mrc,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003050 abnormal sacral vertebrae morphology "malformation of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hoxa10tm1Mrc/Hoxa10tm1Mrc,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxa10tm1Mrc/Hoxa10+,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxa10tm1Mrc/Hoxa10tm1Mrc,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003698 abnormal male reproductive system physiology "anomaly in the function of the male organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0003854 abnormal forelimb stylopod morphology 
Show

Allelic Composition: Hoxa10tm1Mrc/Hoxa10+,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003856 abnormal hindlimb stylopod morphology 
Show

Allelic Composition: Hoxa10tm1Mrc/Hoxa10+,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hoxa10tm1Mrc/Hoxa10tm1Mrc,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004353 abnormal deltoid tuberosity morphology "any structural anomaly of a rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004354 absent deltoid tuberosity "missing the rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hoxa10tm1Mrc/Hoxa10tm1Mrc,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004600 abnormal vertebral transverse process "any structural anomaly of the bony protrusions on either side of the arch of a vertebrae at the point where the lamina joins the pedicle, between the superior and inferior articular processes; muscles and ligaments attach to these processes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxd10tm1Mrc/Hoxd10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa10tm1Mrc/Hoxa10tm1Mrc,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004617 sacral vertebral transformation "homeotic transformation of any sacral vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hoxa10tm1Mrc/Hoxa10tm1Mrc,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004622 sacral vertebral fusion "the union of one or more sacral vertebrae into a single structure in species where this does not normally occur" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004654 absent lumbar vertebrae "absence of all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Hoxa10tm1Mrc/Hoxa10tm1Mrc,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004694 absent patella "absence of the large sesamoid bone that covers the anterior surface of the knee" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hoxa10tm1Mrc/Hoxa10tm1Mrc,Hoxc10tm1Mrc/Hoxc10tm1Mrc,Hoxd10tm1Mrc/Hoxd10tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005296 abnormal humerus morphology "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005353 abnormal patella morphology "anomalous structure of the large sesamoid bone that covers the anterior surface of the knee" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47316]
Show

Allelic Composition: Dll3tm1Rbe/Dll3tm1Rbe
Genetic Background: involves: 129P2/Ola * C57BL/6

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005503 abnormal tendon morphology "structural anomaly of the fibrous bands or cords of connective tissue at the ends of muscle fibers that attach muscles to bones and other structures" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:45509]
Show

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008028 pregnancy-related premature death "death occuring before the normal life span of an organism, occuring during pregnancy, parturition or lactation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009005 abnormal sesamoid bone of gastrocnemius morphology "any structural anomaly of the small sesamoid bones situated behind the condyles of the femur" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009450 abnormal axon fasiculation "anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxd9tm1Emca/Hoxd9tm1Emca,Hoxd10tm1Emca/Hoxd10tm1Emca
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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