ENSMUSG00000001946


Mus musculus

Features
Gene ID: ENSMUSG00000001946
  
Biological name :Esam
  
Synonyms : Endothelial cell-selective adhesion molecule / Esam / Q925F2
  
Possible biological names infered from orthology : endothelial cell adhesion molecule / Q96AP7
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A4
Gene start: 37528078
Gene end: 37538319
  
Corresponding Affymetrix probe sets: 10584317 (MoGene1.0st)   1460356_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002011
Ensembl peptide - ENSMUSP00000149283
Ensembl peptide - ENSMUSP00000122473
Ensembl peptide - ENSMUSP00000116300
Ensembl peptide - ENSMUSP00000114632
NCBI entrez gene - 69524     See in Manteia.
MGI - MGI:1916774
RefSeq - NM_027102
RefSeq Peptide - NP_081378
swissprot - A0A1L1SR18
swissprot - Q3U102
swissprot - D3Z5Y0
swissprot - Q925F2
swissprot - D3Z5S5
swissprot - D3YV70
Ensembl - ENSMUSG00000001946
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 esamaENSDARG00000077039Danio rerio
 esambENSDARG00000076639Danio rerio
 ESAMENSGALG00000032943Gallus gallus
 ESAMENSG00000149564Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Igsf11 / P0C673 / Immunoglobulin superfamily member 11 / Q5DX21*ENSMUSG0000002279031
Vsig2 / Q9Z109 / V-set and immunoglobulin domain containing 2 / Q96IQ7*ENSMUSG0000000194325
Cxadr / P97792 / Coxsackievirus and adenovirus receptor homolog / P78310* / CXADR, Ig-like cell adhesion molecule*ENSMUSG0000002286524
Clmp / Q8R373 / CXADR-like membrane protein / Q9H6B4*ENSMUSG0000003202424
Vsig8 / Q6P3A4 / V-set and immunoglobulin domain containing 8 / P0DPA2*ENSMUSG0000004959821
Gpa33 / glycoprotein A33 (transmembrane) / Q99795* / glycoprotein A33*ENSMUSG0000000054420
Vsig1 / V-set and immunoglobulin domain containing 1 / Q86XK7*ENSMUSG0000003143019
Gm1123ENSMUSG0000004486012


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IDA
 biological_processGO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules TAS
 biological_processGO:0098609 cell-cell adhesion IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005912 adherens junction IDA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Nat2tm1Esim/Nat2tm1Esim
Genetic Background: involves: 129P2/OlaHsd * A/J

Allelic Composition: Esamtm1Dvst/Esamtm1Dvst
Genetic Background: B6.129-Esam1tm1Dvst

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nat2tm1Esim/Nat2tm1Esim
Genetic Background: involves: 129P2/OlaHsd * A/J

 MP:0003071 decreased vascular permeability "reduced or slower ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Esamtm1Dvst/Esamtm1Dvst
Genetic Background: B6.129-Esam1tm1Dvst

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
Show

Allelic Composition: Esamtm1Dvst/Esamtm1Dvst
Genetic Background: B6.129-Esam1tm1Dvst

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Nat2tm1Esim/Nat2tm1Esim
Genetic Background: involves: 129P2/OlaHsd * A/J

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
Show

Allelic Composition: Esamtm1Dvst/Esamtm1Dvst
Genetic Background: B6.129-Esam1tm1Dvst

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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