ENSMUSG00000002769


Mus musculus

Features
Gene ID: ENSMUSG00000002769
  
Biological name :Gnmt
  
Synonyms : glycine N-methyltransferase / Gnmt / Q9QXF8
  
Possible biological names infered from orthology : Q14749
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: C
Gene start: 46725664
Gene end: 46729168
  
Corresponding Affymetrix probe sets: 10451451 (MoGene1.0st)   1417422_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002846
NCBI entrez gene - 14711     See in Manteia.
MGI - MGI:1202304
RefSeq - NM_010321
RefSeq Peptide - NP_034451
swissprot - Q9QXF8
Ensembl - ENSMUSG00000002769
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gnmtENSDARG00000006840Danio rerio
 GNMTENSGALG00000043290Gallus gallus
 GNMTENSG00000124713Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR014369  Glycine/Sarcosine N-methyltransferase
 IPR025714  Methyltransferase domain
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005977 glycogen metabolic process IMP
 biological_processGO:0006111 regulation of gluconeogenesis IMP
 biological_processGO:0006555 methionine metabolic process IMP
 biological_processGO:0006730 one-carbon metabolic process IMP
 biological_processGO:0032259 methylation IEA
 biological_processGO:0046500 S-adenosylmethionine metabolic process IDA
 biological_processGO:0051289 protein homotetramerization IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005542 folic acid binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016594 glycine binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017174 glycine N-methyltransferase activity ISO
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Glyoxylate metabolism and glycine degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdkn2atm3(cre)Cjs/Cdkn2atm4Cjs
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn2atm3(cre)Cjs/Cdkn2atm4Cjs
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn2atm3(cre)Cjs/Cdkn2atm4Cjs
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Cdkn2atm3(cre)Cjs/Cdkn2atm4Cjs
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Cdkn2atm3(cre)Cjs/Cdkn2atm4Cjs
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000602 enlarged sinusoidal spaces "larger than normal sized cavities in the liver " [J:23170]
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Allelic Composition: Cdkn2atm3(cre)Cjs/Cdkn2atm4Cjs
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn2atm3(cre)Cjs/Cdkn2atm4Cjs
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002047 hepatic hemangioma "neoplastic- like masses in the liver; often undergoes spontaneous regression" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Cdkn2atm3(cre)Cjs/Cdkn2atm4Cjs
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2atm3(cre)Cjs/Cdkn2atm4Cjs
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn2atm3(cre)Cjs/Cdkn2atm4Cjs
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2atm3(cre)Cjs/Cdkn2atm4Cjs
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
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Allelic Composition: Cdkn2atm3(cre)Cjs/Cdkn2atm4Cjs
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Cdkn2atm3(cre)Cjs/Cdkn2atm4Cjs
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2atm3(cre)Cjs/Cdkn2atm4Cjs
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn2atm3(cre)Cjs/Cdkn2atm4Cjs
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
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Allelic Composition: Cdkn2atm3(cre)Cjs/Cdkn2atm4Cjs
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fgfr3tm4Cxd/Fgfr3+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * NIH Black Swiss * SJL

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn2atm3(cre)Cjs/Cdkn2atm4Cjs
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010400 increased liver glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn2atm3(cre)Cjs/Cdkn2atm4Cjs
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002769 Gnmt / Q9QXF8 / glycine N-methyltransferase / Q14749*  / complex






 

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