ENSMUSG00000003476


Mus musculus
receptorCrhr2familygpcractivitysignalingdecreasedhormonecellregulationincreasedlevelfactorresponsemembranecirculatingfatsecretin-likeextracellulardomaincorticotropinreleasingsignalsurfacepathwayg-proteincoupledangiogenesiscamp-mediatedbloodpressure

Features
Gene ID: ENSMUSG00000003476
  
Biological name :Crhr2
  
Synonyms : Corticotropin-releasing factor receptor 2 / Crhr2 / Q60748
  
Possible biological names infered from orthology : corticotropin releasing hormone receptor 2 / Q13324
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B3
Gene start: 55090049
Gene end: 55133016
  
Corresponding Affymetrix probe sets: 10544913 (MoGene1.0st)   1422012_at (Mouse Genome 430 2.0 Array)   1450462_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126673
Ensembl peptide - ENSMUSP00000110015
Ensembl peptide - ENSMUSP00000148297
Ensembl peptide - ENSMUSP00000148408
Ensembl peptide - ENSMUSP00000003568
Ensembl peptide - ENSMUSP00000093586
NCBI entrez gene - 12922     See in Manteia.
MGI - MGI:894312
RefSeq - XM_006505482
RefSeq - NM_001288618
RefSeq - NM_001288619
RefSeq - NM_001288620
RefSeq - NM_009953
RefSeq Peptide - NP_001275547
RefSeq Peptide - NP_001275548
RefSeq Peptide - NP_001275549
RefSeq Peptide - NP_034083
swissprot - Q3UQP0
swissprot - Q60748
swissprot - Q5ERJ2
swissprot - A0A1D5RLK7
swissprot - E9QNK5
swissprot - E9PXI8
Ensembl - ENSMUSG00000003476
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 crhr2ENSDARG00000103704Danio rerio
 CRHR2ENSGALG00000005657Gallus gallus
 CRHR2ENSG00000106113Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Crhr1 / P35347 / Corticotropin-releasing factor receptor 1 / P34998* / LINC02210-CRHR1* / LINC02210-CRHR1 readthrough* / corticotropin releasing hormone receptor 1*ENSMUSG0000001863465
Calcr / Q60755 / Mus musculus calcitonin receptor (Calcr), transcript variant 3, mRNA. / P30988* / calcitonin receptor*ENSMUSG0000002396431
Calcrl / Q9R1W5 / Calcitonin-related peptide type 1 receptor / Q16602* / calcitonin receptor like receptor*ENSMUSG0000005958829


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR003051  GPCR, family 2, corticotropin releasing factor receptor
 IPR003053  GPCR, family 2, corticotropin releasing factor receptor, type 2
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
cell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentresponse to endogenous stimulusresponse to chemicalcell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentresponse to endogenous stimulusresponse to chemicalcell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentresponse to endogenous stimulusresponse to chemicalcell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentresponse to endogenous stimulusresponse to chemicalcell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentresponse to endogenous stimulusresponse to chemicalcell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentresponse to endogenous stimulusresponse to chemicalcell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentresponse to endogenous stimulusresponse to chemicalcell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentresponse to endogenous stimulusresponse to chemicalcell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentresponse to endogenous stimulusresponse to chemicalcell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentresponse to endogenous stimulusresponse to chemicalcell communicationcell communicationcellular response to stcellular response to stimulusregulation of molecularregulation of molecular functionanatomical structure deanatomical structure developmentresponse to endogenous response to endogenous stimulusresponse to chemicalresponse to chemical
signaling receptor activityprotein bindingreceptor regulator activitysignaling receptor activityprotein bindingreceptor regulator activitysignaling receptor activityprotein bindingreceptor regulator activitysignaling receptor activityprotein bindingreceptor regulator activitysignaling receptor activityprotein bindingreceptor regulator activitysignaling receptor activityprotein bindingreceptor regulator activitysignaling receptor activityprotein bindingreceptor regulator activitysignaling receptor activityprotein bindingreceptor regulator activitysignaling receptor activityprotein bindingreceptor regulator activitysignaling receptor activityprotein bindingreceptor regulator activitysignaling receptor activitysignaling receptor activityprotein bindingprotein bindingreceptor regulator activityreceptor regulator activity
cellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellcellorganelleorganellemembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016525 negative regulation of angiogenesis IMP
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IDA
 biological_processGO:0043951 negative regulation of cAMP-mediated signaling IDA
 biological_processGO:0071376 cellular response to corticotropin-releasing hormone stimulus IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005179 hormone activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015056 corticotrophin-releasing factor receptor activity IDA


Pathways (from Reactome)
Pathway description
Class B/2 (Secretin family receptors)
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
cardiovascular system phenotypeendocrine/exocrine gland phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypeadipose tissue phenotypecardiovascular system phenotypeendocrine/exocrine gland phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypeadipose tissue phenotypecardiovascular system phenotypeendocrine/exocrine gland phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypeadipose tissue phenotypecardiovascular system phenotypeendocrine/exocrine gland phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypeadipose tissue phenotypecardiovascular system phenotypeendocrine/exocrine gland phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypeadipose tissue phenotypecardiovascular system phenotypeendocrine/exocrine gland phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypeadipose tissue phenotypecardiovascular system phenotypeendocrine/exocrine gland phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypeadipose tissue phenotypecardiovascular system phenotypeendocrine/exocrine gland phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypeadipose tissue phenotypecardiovascular system phenotypeendocrine/exocrine gland phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypeadipose tissue phenotypecardiovascular system phenotypeendocrine/exocrine gland phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypeadipose tissue phenotypecardiovascular system phenotcardiovascular system phenotypeendocrine/exocrine gland pheendocrine/exocrine gland phenotypebehavior/neurological phenotbehavior/neurological phenotypehomeostasis/metabolism phenohomeostasis/metabolism phenotypeadipose tissue phenotypeadipose tissue phenotype
IDPhenotypeDefinition Genetic BG
 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0000640 adrenal gland hypoplasia "underdeveloped endocrine glands located above the kidney and responsible for hormone and epinephrine secretion, resulting from reduced numbers of cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001362 abnormal anxiety-related response "altered emotional response related to anticipation of a non-specific threat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

Allelic Composition: Crhr2tm1Jsp/Crhr2tm1Jsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Crhr2tm1Jsp/Crhr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: 129/Sv

 MP:0001442 decreased grooming behavior "reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: 129/Sv

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0001619 abnormal vascular permeability "anomaly in the ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Crhr2tm1Jsp/Crhr2tm1Jsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: 129/Sv

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Crhr2tm1Mpsp/Crhr2tm1Mpsp
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Crhr2tm1Mpsp/Crhr2tm1Mpsp
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0005601 increased angiogenesis "enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0005666 abnormal adipose tissue physiology "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0008294 abnormal zona fasciculata morphology "any structural anomaly of the wide middle zone of the adrenal cortex that produces cortisol (hydrocortisone)" [MESH:A06.407.071.140.950]
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Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009117 abnormal white fat cell morphology "any structural anomaly of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0009136 decreased brown fat cell size "reduction in the size of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000049796 Crh / Q8CIT0 / Corticoliberin / P06850* / corticotropin releasing hormone*  / complex / reaction
 ENSMUSG00000038676 Ucn / P81615 / urocortin / P55089*  / complex / reaction
 ENSMUSG00000044988 Ucn3 / Q924A4 / urocortin 3 / Q969E3*  / complex / reaction
 ENSMUSG00000049699 Ucn2 / Q99ML8 / urocortin 2 / Q96RP3*  / complex / reaction






 

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