ENSMUSG00000038676


Mus musculus

Features
Gene ID: ENSMUSG00000038676
  
Biological name :Ucn
  
Synonyms : P81615 / Ucn / urocortin
  
Possible biological names infered from orthology : P55089
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B1
Gene start: 31138063
Gene end: 31138829
  
Corresponding Affymetrix probe sets: 10529077 (MoGene1.0st)   1450610_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035321
Ensembl peptide - ENSMUSP00000144390
NCBI entrez gene - 22226     See in Manteia.
MGI - MGI:1276123
RefSeq - NM_021290
RefSeq Peptide - NP_001332939
RefSeq Peptide - NP_067265
swissprot - P81615
Ensembl - ENSMUSG00000038676
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 uts1ENSDARG00000014927Danio rerio
 UCNENSG00000163794Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000187  Corticotropin-releasing factor
 IPR003620  Urocortin/corticotropin-releasing factor
 IPR018446  Corticotropin-releasing factor conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001964 startle response IMP
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0007631 feeding behavior IEA
 biological_processGO:0008306 associative learning IEA
 biological_processGO:0009060 aerobic respiration IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010996 response to auditory stimulus IMP
 biological_processGO:0030157 pancreatic juice secretion IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0031064 negative regulation of histone deacetylation IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0032099 negative regulation of appetite IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034199 activation of protein kinase A activity IEA
 biological_processGO:0035176 social behavior IEA
 biological_processGO:0035483 gastric emptying IEA
 biological_processGO:0042756 drinking behavior IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043117 positive regulation of vascular permeability IEA
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045776 negative regulation of blood pressure IEA
 biological_processGO:0045792 negative regulation of cell size IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0046888 negative regulation of hormone secretion IEA
 biological_processGO:0048265 response to pain IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051461 positive regulation of corticotropin secretion ISO
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0060452 positive regulation of cardiac muscle contraction IEA
 biological_processGO:0060455 negative regulation of gastric acid secretion IEA
 biological_processGO:0060547 negative regulation of necrotic cell death IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0090280 positive regulation of calcium ion import IEA
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:2000252 negative regulation of feeding behavior IBA
 biological_processGO:2000987 positive regulation of behavioral fear response IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043196 varicosity IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043679 axon terminus IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0046811 histone deacetylase inhibitor activity IEA
 molecular_functionGO:0051430 corticotropin-releasing hormone receptor 1 binding IEA
 molecular_functionGO:0051431 corticotropin-releasing hormone receptor 2 binding IEA


Pathways (from Reactome)
Pathway description
Class B/2 (Secretin family receptors)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Mecp2tm2.1Jae/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mecp2tm2.1Jae/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Mecp2tm2.1Jae/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Ncoa1tm1Bwo/Ncoa1tm1Bwo,Ncoa2tm1.1Ipc/Ncoa2tm1.1Ipc,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0002572 abnormal emotion/affect behavior "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ncoa1tm1Bwo/Ncoa1tm1Bwo,Ncoa2tm1.1Ipc/Ncoa2tm1.1Ipc,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Mecp2tm2.1Jae/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004466 short cochlear outer hair cells 
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Allelic Composition: Mecp2tm2.1Jae/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004736 abnormal distortion product otoacoustic emission "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecp2tm2.1Jae/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005345 abnormal circulating corticosterone level "anomalous blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ncoa1tm1Bwo/Ncoa1tm1Bwo,Ncoa2tm1.1Ipc/Ncoa2tm1.1Ipc,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Mecp2tm2.1Jae/Y
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003476 Crhr2 / Q60748 / Corticotropin-releasing factor receptor 2 / Q13324* / corticotropin releasing hormone receptor 2*  / complex / reaction
 ENSMUSG00000018634 Crhr1 / P35347 / Corticotropin-releasing factor receptor 1 / P34998* / LINC02210-CRHR1* / LINC02210-CRHR1 readthrough* / corticotropin releasing hormone receptor 1*  / complex / reaction






 

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