ENSMUSG00000003721


Mus musculus

Features
Gene ID: ENSMUSG00000003721
  
Biological name :Insig2
  
Synonyms : Insig2 / Insulin-induced 2 protein / Q91WG1
  
Possible biological names infered from orthology : insulin induced gene 2 / Q9Y5U4
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E2.3
Gene start: 121304353
Gene end: 121332589
  
Corresponding Affymetrix probe sets: 10357280 (MoGene1.0st)   1417980_a_at (Mouse Genome 430 2.0 Array)   1417981_at (Mouse Genome 430 2.0 Array)   1417982_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123729
Ensembl peptide - ENSMUSP00000140292
Ensembl peptide - ENSMUSP00000125216
Ensembl peptide - ENSMUSP00000125046
Ensembl peptide - ENSMUSP00000124697
Ensembl peptide - ENSMUSP00000124345
Ensembl peptide - ENSMUSP00000123993
Ensembl peptide - ENSMUSP00000123747
Ensembl peptide - ENSMUSP00000003818
Ensembl peptide - ENSMUSP00000065485
Ensembl peptide - ENSMUSP00000123702
NCBI entrez gene - 72999     See in Manteia.
MGI - MGI:1920249
RefSeq - XM_006529892
RefSeq - NM_001271531
RefSeq - NM_001271532
RefSeq - NM_133748
RefSeq - NM_178082
RefSeq - XM_006529889
RefSeq - XM_006529890
RefSeq - XM_006529891
RefSeq Peptide - NP_835183
RefSeq Peptide - NP_001258460
RefSeq Peptide - NP_001258461
RefSeq Peptide - NP_001344180
RefSeq Peptide - NP_598509
swissprot - E0CZ00
swissprot - E0CYQ1
swissprot - E0CXS5
swissprot - E0CXL0
swissprot - Q91WG1
swissprot - E0CZ15
swissprot - E0CXF1
swissprot - A0A087WQP7
Ensembl - ENSMUSG00000003721
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 insig2ENSDARG00000113367Danio rerio
 INSIG2ENSGALG00000028046Gallus gallus
 INSIG2ENSG00000125629Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Insig1 / Q8BGI3 / Insulin-induced 1 protein / O15503* / insulin induced gene 1*ENSMUSG0000004529470


Protein motifs (from Interpro)
Interpro ID Name
 IPR025929  Insulin-induced protein family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006641 triglyceride metabolic process IGI
 biological_processGO:0006695 cholesterol biosynthetic process IGI
 biological_processGO:0006991 response to sterol depletion IDA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0010894 negative regulation of steroid biosynthetic process IGI
 biological_processGO:0016126 sterol biosynthetic process IGI
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0032933 SREBP signaling pathway ISO
 biological_processGO:0033993 response to lipid IEA
 biological_processGO:0042472 inner ear morphogenesis IGI
 biological_processGO:0042474 middle ear morphogenesis IGI
 biological_processGO:0045717 negative regulation of fatty acid biosynthetic process IGI
 biological_processGO:0060021 roof of mouth development IGI
 biological_processGO:0060363 cranial suture morphogenesis IGI
 biological_processGO:0070542 response to fatty acid IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032937 SREBP-SCAP-Insig complex ISO
 molecular_functionGO:0008134 transcription factor binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bace1tm1Psa/Bace1tm1Psa,Bace2tm1Bdes/Bace2tm1Bdes
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6J) or (involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * CD-1)

Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0002139 abnormal liver/biliary system physiology "altered function of the liver not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
Show

Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0010027 increased liver cholesterol level "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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