ENSMUSG00000045294


Mus musculus

Features
Gene ID: ENSMUSG00000045294
  
Biological name :Insig1
  
Synonyms : Insig1 / Insulin-induced 1 protein / Q8BGI3
  
Possible biological names infered from orthology : insulin induced gene 1 / O15503
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B1
Gene start: 28071363
Gene end: 28078662
  
Corresponding Affymetrix probe sets: 10520362 (MoGene1.0st)   1454671_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000061877
NCBI entrez gene - 231070     See in Manteia.
MGI - MGI:1916289
RefSeq - NM_153526
RefSeq Peptide - NP_705746
swissprot - Q8BGI3
Ensembl - ENSMUSG00000045294
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 insig1ENSDARG00000010658Danio rerio
 INSIG1ENSGALG00000017394Gallus gallus
 INSIG1ENSG00000186480Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Insig2 / Q91WG1 / Insulin-induced 2 protein / Q9Y5U4* / insulin induced gene 2*ENSMUSG0000000372161


Protein motifs (from Interpro)
Interpro ID Name
 IPR009904  Insulin-induced gene 1 protein
 IPR025929  Insulin-induced protein family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006641 triglyceride metabolic process IGI
 biological_processGO:0006695 cholesterol biosynthetic process IGI
 biological_processGO:0006991 response to sterol depletion IDA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IGI
 biological_processGO:0010894 negative regulation of steroid biosynthetic process IGI
 biological_processGO:0016126 sterol biosynthetic process IGI
 biological_processGO:0032933 SREBP signaling pathway IEA
 biological_processGO:0036315 cellular response to sterol IEA
 biological_processGO:0036316 SREBP-SCAP complex retention in endoplasmic reticulum IEA
 biological_processGO:0042472 inner ear morphogenesis IGI
 biological_processGO:0042474 middle ear morphogenesis IGI
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IDA
 biological_processGO:0045717 negative regulation of fatty acid biosynthetic process IGI
 biological_processGO:0060021 roof of mouth development IGI
 biological_processGO:0060363 cranial suture morphogenesis IGI
 biological_processGO:0070862 negative regulation of protein exit from endoplasmic reticulum IEA
 biological_processGO:1901303 negative regulation of cargo loading into COPII-coated vesicle IEA
 cellular_componentGO:0005783 endoplasmic reticulum TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032937 SREBP-SCAP-Insig complex IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Abcc8tm1.1Fmas/Abcc8tm1.1Fmas
Genetic Background: B6.129S2(Cg)-Abcc8tm1.1Fmas

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Abcc8tm1.1Fmas/Abcc8tm1.1Fmas
Genetic Background: B6.129S2(Cg)-Abcc8tm1.1Fmas

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bace1tm1Psa/Bace1tm1Psa,Bace2tm1Bdes/Bace2tm1Bdes
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6J) or (involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * CD-1)

Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0002139 abnormal liver/biliary system physiology "altered function of the liver not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

Allelic Composition: Insig1tm1.1Aztc/Insig1tm1.1Aztc
Genetic Background: Not Specified

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
Show

Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0009117 abnormal white fat cell morphology "any structural anomaly of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500]
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Allelic Composition: Insig1tm1.1Aztc/Insig1tm1.1Aztc
Genetic Background: Not Specified

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Insig1tm1.1Aztc/Insig1tm1.1Aztc
Genetic Background: Not Specified

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0010027 increased liver cholesterol level "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0010934 increased subcutaneous adipose tissue amount "increase in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Insig1tm1.1Aztc/Insig1tm1.1Aztc
Genetic Background: Not Specified

 MP:0011169 abnormal white fat cell differentation "abnormal or arrest of differentiation of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500, MGI:csmith]
Show

Allelic Composition: Insig1tm1.1Aztc/Insig1tm1.1Aztc
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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