ENSMUSG00000004344


Mus musculus

Features
Gene ID: ENSMUSG00000004344
  
Biological name :Gpx5
  
Synonyms : Epididymal secretory glutathione peroxidase / Gpx5 / P21765
  
Possible biological names infered from orthology : glutathione peroxidase 5 / O75715
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A3.1
Gene start: 21286429
Gene end: 21292731
  
Corresponding Affymetrix probe sets: 10407999 (MoGene1.0st)   1420698_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106117
NCBI entrez gene - 14780     See in Manteia.
MGI - MGI:104886
RefSeq - NM_010343
RefSeq Peptide - NP_034473
swissprot - P21765
Ensembl - ENSMUSG00000004344
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpx3ENSDARG00000043342Danio rerio
 GPX3ENSGALG00000004521Gallus gallus
 GPX5ENSG00000224586Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpx3 / P46412 / Glutathione peroxidase 3 / P22352*ENSMUSG0000001833966
Gpx6 / Q91WR8 / Glutathione peroxidase 6 / P59796*ENSMUSG0000000434164
Gpx1 / P11352 / Mus musculus glutathione peroxidase 1 (Gpx1), transcript variant 2, mRNA. / P07203* / glutathione peroxidase 1*ENSMUSG0000006385642
Gpx2 / glutathione peroxidase 2 / P18283*ENSMUSG0000004280838
Gpx7 / Q99LJ6 / Glutathione peroxidase 7 / Q96SL4*ENSMUSG0000002859727
Gpx4 / O70325 / Phospholipid hydroperoxide glutathione peroxidase, mitochondrial / P36969* / glutathione peroxidase 4*ENSMUSG0000007570624
Gpx8 / Q9D7B7 / Probable glutathione peroxidase 8 / Q8TED1* / glutathione peroxidase 8 (putative)*ENSMUSG0000002176023


Protein motifs (from Interpro)
Interpro ID Name
 IPR000889  Glutathione peroxidase
 IPR029759  Glutathione peroxidase active site
 IPR029760  Glutathione peroxidase conserved site
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0034599 cellular response to oxidative stress IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0097524 sperm plasma membrane IDA
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0004602 glutathione peroxidase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Ghrtm1.2Masp/Ghrtm1.2Masp
Genetic Background: involves: 129S4/SvJaeSor

 MP:0009232 abnormal sperm nucleus morphology "any structural abnormality of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ghrtm1.2Masp/Ghrtm1.2Masp
Genetic Background: involves: 129S4/SvJaeSor

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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