ENSMUSG00000042808


Mus musculus

Features
Gene ID: ENSMUSG00000042808
  
Biological name :Gpx2
  
Synonyms : glutathione peroxidase 2 / Gpx2
  
Possible biological names infered from orthology : P18283
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: C3
Gene start: 76792333
Gene end: 76795554
  
Corresponding Affymetrix probe sets: 10401109 (MoGene1.0st)   1449279_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000081012
NCBI entrez gene - 14777     See in Manteia.
NCBI entrez gene - 14776     See in Manteia.
MGI - MGI:106609
RefSeq - NM_030677
RefSeq Peptide - NP_109602
swissprot - A0A0R4J111
Ensembl - ENSMUSG00000042808
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpx1aENSDARG00000018146Danio rerio
 gpx1bENSDARG00000006207Danio rerio
 GPX2ENSGALG00000042031Gallus gallus
 GPX2ENSG00000176153Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpx1 / P11352 / Mus musculus glutathione peroxidase 1 (Gpx1), transcript variant 2, mRNA. / P07203* / glutathione peroxidase 1*ENSMUSG0000006385663
Gpx6 / Q91WR8 / Glutathione peroxidase 6 / P59796*ENSMUSG0000000434144
Gpx5 / P21765 / Epididymal secretory glutathione peroxidase / O75715* / glutathione peroxidase 5*ENSMUSG0000000434444
Gpx3 / P46412 / Glutathione peroxidase 3 / P22352*ENSMUSG0000001833942
Gpx7 / Q99LJ6 / Glutathione peroxidase 7 / Q96SL4*ENSMUSG0000002859730
Gpx4 / O70325 / Phospholipid hydroperoxide glutathione peroxidase, mitochondrial / P36969* / glutathione peroxidase 4*ENSMUSG0000007570628
Gpx8 / Q9D7B7 / Probable glutathione peroxidase 8 / Q8TED1* / glutathione peroxidase 8 (putative)*ENSMUSG0000002176027


Protein motifs (from Interpro)
Interpro ID Name
 IPR000889  Glutathione peroxidase
 IPR029759  Glutathione peroxidase active site
 IPR029760  Glutathione peroxidase conserved site
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0004602 glutathione peroxidase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of 12-eicosatetraenoic acid derivatives
Synthesis of 15-eicosatetraenoic acid derivatives
Detoxification of Reactive Oxygen Species
TP53 Regulates Metabolic Genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000491 crypt abscesses "an exudate collection associated with inflammation in the crypts of Lieberkuhn of the intestinal mucosa; often associated with ulcerative colitis" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh,Gpx2tm2Coh/Gpx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gpx1tm1Ysh/Gpx1+,Gpx2tm2Coh/Gpx2tm2Coh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gpx1tm1Ysh/Gpx1+,Gpx2tm2Coh/Gpx2tm2Coh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003288 intestinal edema "an accumulation of an excessive amount of serous fluid in the intestine or intestinal cells " [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005035 perianal ulceration "lesion around or near the anus" [cml:Cathy M Lutz , Mouse Genome Informatics Curator, J:71506]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gpx1tm1Ysh/Gpx1+,Gpx2tm2Coh/Gpx2tm2Coh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh,Gpx2tm2Coh/Gpx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gpx1tm1Ysh/Gpx1+,Gpx2tm2Coh/Gpx2tm2Coh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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