ENSMUSG00000004709


Mus musculus

Features
Gene ID: ENSMUSG00000004709
  
Biological name :Cd244
  
Synonyms : Cd244 / Natural killer cell receptor 2B4 / Q07763
  
Possible biological names infered from orthology : CD244 molecule / Q9BZW8
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H3
Gene start: 171559193
Gene end: 171609746
  
Corresponding Affymetrix probe sets: 10351644 (MoGene1.0st)   1426120_a_at (Mouse Genome 430 2.0 Array)   1449991_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004829
Ensembl peptide - ENSMUSP00000141898
NCBI entrez gene - 18106     See in Manteia.
MGI - MGI:109294
RefSeq - XM_006496695
RefSeq - NM_018729
RefSeq Peptide - NP_061199
swissprot - Q07763
swissprot - Q3TAZ6
Ensembl - ENSMUSG00000004709
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000040002Gallus gallus
 CD244ENSG00000122223Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013783  Immunoglobulin-like fold
 IPR024303  Natural killer cell receptor 2B4, immunoglobulin domain
 IPR024304  Natural killer cell receptor 2B4
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001773 myeloid dendritic cell activation IMP
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002323 natural killer cell activation involved in immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0032819 positive regulation of natural killer cell proliferation IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0060732 positive regulation of inositol phosphate biosynthetic process ISO
 biological_processGO:0071663 positive regulation of granzyme B production ISO
 biological_processGO:1902715 positive regulation of interferon-gamma secretion ISO
 biological_processGO:2000484 positive regulation of interleukin-8 secretion ISO
 biological_processGO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042288 MHC class I protein binding ISO


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003080 competent NK cell cytolysis "ability of these cells to destroy or dissolve targeted cells" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cd83lcd4/Cd83lcd4
Genetic Background: involves: C57BL/6J

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
Show

Allelic Composition: Cd83lcd4/Cd83lcd4
Genetic Background: involves: C57BL/6J

Allelic Composition: Cd244aChip/Cd244aChip
Genetic Background: C57BL/6J-Cd244Chip

Allelic Composition: Cd244aChip/Cd244a+
Genetic Background: C57BL/6J-Cd244Chip

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
Show

Allelic Composition: Cd244aChip/Cd244aChip
Genetic Background: C57BL/6J-Cd244Chip

Allelic Composition: Cd244aChip/Cd244a+
Genetic Background: C57BL/6J-Cd244Chip

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015355 Cd48 / P18181 / CD48 antigen / P09326* / CD48 molecule*  / complex / reaction






 

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