ENSMUSG00000005220


Mus musculus

Features
Gene ID: ENSMUSG00000005220
  
Biological name :Corin
  
Synonyms : Atrial natriuretic peptide-converting enzyme Atrial natriuretic peptide-converting enzyme, N-terminal propeptide Atrial natriuretic peptide-converting enzyme, activated protease fragment Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment / Corin / Q9Z319
  
Possible biological names infered from orthology : corin, serine peptidase / Q9Y5Q5
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: C3.2
Gene start: 72300025
Gene end: 72504473
  
Corresponding Affymetrix probe sets: 10530441 (MoGene1.0st)   1419017_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135511
Ensembl peptide - ENSMUSP00000005352
Ensembl peptide - ENSMUSP00000127389
Ensembl peptide - ENSMUSP00000135722
Ensembl peptide - ENSMUSP00000135889
NCBI entrez gene - 53419     See in Manteia.
MGI - MGI:1349451
RefSeq - XM_017320986
RefSeq - NM_001122756
RefSeq - NM_016869
RefSeq - XM_011240755
RefSeq Peptide - NP_001116228
RefSeq Peptide - NP_058565
swissprot - H3BKS9
swissprot - H3BLR7
swissprot - H3BLB2
swissprot - Q9Z319
Ensembl - ENSMUSG00000005220
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 corinENSDARG00000101281Danio rerio
 CORINENSGALG00000014144Gallus gallus
 CORINENSG00000145244Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
St14 / P56677 / suppression of tumorigenicity 14 (colon carcinoma) / Q9Y5Y6* / suppression of tumorigenicity 14*ENSMUSG0000003199517
Q8BIK6 / Tmprss7 / Transmembrane protease serine 7 / Q7RTY8* / transmembrane serine protease 7*ENSMUSG0000003317717
Q9DBI0 / Tmprss6 / Mus musculus transmembrane serine protease 6 (Tmprss6), transcript variant 2, mRNA. / Q8IU80* / transmembrane serine protease 6*ENSMUSG0000001694216
P97435 / Tmprss15 / transmembrane protease, serine 15 / P98073* / transmembrane serine protease 15*ENSMUSG0000002285716
Q9JIQ8 / Tmprss2 / Transmembrane protease serine 2 Transmembrane protease serine 2 non-catalytic chain Transmembrane protease serine 2 catalytic chain / O15393* / transmembrane serine protease 2*ENSMUSG0000000038513
F11 / Q91Y47 / Coagulation factor XI Coagulation factor XIa heavy chain Coagulation factor XIa light chain / P03951* / coagulation factor XI*ENSMUSG0000003164513
Tmprss13 / transmembrane serine protease 13 / Q9BYE2*ENSMUSG0000003712913
Klkb1 / P26262 / Plasma kallikrein Plasma kallikrein heavy chain Plasma kallikrein light chain / P03952* / kallikrein B1*ENSMUSG0000010976413
Q8K1T0 / Tmprss3 / transmembrane protease, serine 3 / P57727* / transmembrane serine protease 3*ENSMUSG0000002403412
Q9ER04 / Tmprss5 / transmembrane protease, serine 5 (spinesin) / Q9H3S3* / transmembrane serine protease 5*ENSMUSG0000003226812
Tmprss9 / transmembrane protease, serine 9 / Q7Z410* / transmembrane serine protease 9*ENSMUSG0000005940612
Q8VCA5 / Tmprss4 / Transmembrane protease serine 4 / Q9NRS4* / transmembrane serine protease 4*ENSMUSG0000003209111
Hpn / O35453 / Serine protease hepsin Serine protease hepsin non-catalytic chain Serine protease hepsin catalytic chain / hepsin* / P05981*ENSMUSG0000000124910


Protein motifs (from Interpro)
Interpro ID Name
 IPR001190  SRCR domain
 IPR001254  Serine proteases, trypsin domain
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR009003  Peptidase S1, PA clan
 IPR017052  Atrial natriuretic peptide-converting enzyme corin
 IPR017448  SRCR-like domain
 IPR020067  Frizzled domain
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR036055  LDL receptor-like superfamily
 IPR036772  SRCR-like domain superfamily
 IPR036790  Frizzled cysteine-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0008217 regulation of blood pressure IMP
 biological_processGO:0016486 peptide hormone processing IEA
 biological_processGO:0030182 neuron differentiation ISO
 biological_processGO:0035813 regulation of renal sodium excretion IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane ISO
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Physiological factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Snta1tm1Scf/Snta1tm1Scf,Sntb2tm1Maad/Sntb2tm1Maad
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Xisttm4Sado/Y
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Aw/Aw,Corintm1Bamo/Corintm1Bamo
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Corintm1Bamo/Corintm1Bamo
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0000400 abnormal awl hair "anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Corintm1Bamo/Corintm1Bamo
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000402 abnormal zigzag hairs "anomalies of truncal hairs that contain one air cell in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Corintm1Bamo/Corintm1Bamo
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000405 abnormal auchene hairs "anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * FVB/N

 MP:0000423 delayed hair regrowth "slow initiation and asynchrony of the hair growth cycle (anagen) after catagen phase " [J:61509]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Snta1tm1Scf/Snta1tm1Scf,Sntb2tm1Maad/Sntb2tm1Maad
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Snta1tm1Scf/Snta1tm1Scf,Sntb2tm1Maad/Sntb2tm1Maad
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Snta1tm1Scf/Snta1tm1Scf,Sntb2tm1Maad/Sntb2tm1Maad
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0004217 salt-sensitive hypertension "sustained high blood pressure that is maintained with a normal or increase in the amount of salt consumed in the diet; blood pressure may return to normotensive with a low salt diet" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Snta1tm1Scf/Snta1tm1Scf,Sntb2tm1Maad/Sntb2tm1Maad
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Snta1tm1Scf/Snta1tm1Scf,Sntb2tm1Maad/Sntb2tm1Maad
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Snta1tm1Scf/Snta1tm1Scf,Sntb2tm1Maad/Sntb2tm1Maad
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008858 abnormal hair cycle anagen phase "anomaly in the growth phase of the hair cycle" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008859 abnormal hair cycle catagen phase "anomaly in the phase of the hair growth cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored hair is produced" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008860 abnormal hair cycle telogen phase "anomaly in the resting or quiescent phase of the hair growth cycle which follows cessation of proliferation (catagen) and preceeds hair loss" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0009272 decreased guard hair length "reduction in the length of the long, straight truncal hairs that contain two air cells in the medulla" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities"]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0011194 abnormal hair follicle physiology "any functional anomaly of the invagination of the epidermis from which the hair shaft develops" [MESH:A10.272.497.500, MGI:mnk]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0011195 increased hair follicle apoptosis "greater than expected levels of programmed cell death of cells in the epidermis from which the hair shaft develops" [MGI:mnk]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000041616 Nppa / P05125 / natriuretic peptide type A / P01160* / natriuretic peptide A*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr