ENSMUSG00000001249


Mus musculus

Features
Gene ID: ENSMUSG00000001249
  
Biological name :Hpn
  
Synonyms : Hpn / O35453 / Serine protease hepsin Serine protease hepsin non-catalytic chain Serine protease hepsin catalytic chain
  
Possible biological names infered from orthology : hepsin / P05981
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B1
Gene start: 31098725
Gene end: 31115290
  
Corresponding Affymetrix probe sets: 10562234 (MoGene1.0st)   1420712_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130966
Ensembl peptide - ENSMUSP00000127229
Ensembl peptide - ENSMUSP00000103737
Ensembl peptide - ENSMUSP00000038149
Ensembl peptide - ENSMUSP00000145624
Ensembl peptide - ENSMUSP00000132307
Ensembl peptide - ENSMUSP00000131658
NCBI entrez gene - 15451     See in Manteia.
MGI - MGI:1196620
RefSeq - NM_008281
RefSeq - NM_001276269
RefSeq - NM_001110252
RefSeq Peptide - NP_032307
RefSeq Peptide - NP_001263198
RefSeq Peptide - NP_001103722
swissprot - O35453
swissprot - A0A0U1RNM3
swissprot - E9Q3X9
swissprot - E9Q5P0
swissprot - F6W6S4
swissprot - F7C9T6
swissprot - G3UWE8
Ensembl - ENSMUSG00000001249
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hpnENSDARG00000027609Danio rerio
 HPNENSG00000105707Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8K1T0 / Tmprss3 / transmembrane protease, serine 3 / P57727* / transmembrane serine protease 3*ENSMUSG0000002403431
Q9JIQ8 / Tmprss2 / Transmembrane protease serine 2 Transmembrane protease serine 2 non-catalytic chain Transmembrane protease serine 2 catalytic chain / O15393* / transmembrane serine protease 2*ENSMUSG0000000038530
Q9ER04 / Tmprss5 / transmembrane protease, serine 5 (spinesin) / Q9H3S3* / transmembrane serine protease 5*ENSMUSG0000003226830
Tmprss13 / transmembrane serine protease 13 / Q9BYE2*ENSMUSG0000003712929
P97435 / Tmprss15 / transmembrane protease, serine 15 / P98073* / transmembrane serine protease 15*ENSMUSG0000002285728
Q8BIK6 / Tmprss7 / Transmembrane protease serine 7 / Q7RTY8* / transmembrane serine protease 7*ENSMUSG0000003317728
F11 / Q91Y47 / Coagulation factor XI Coagulation factor XIa heavy chain Coagulation factor XIa light chain / P03951* / coagulation factor XI*ENSMUSG0000003164527
St14 / P56677 / suppression of tumorigenicity 14 (colon carcinoma) / Q9Y5Y6* / suppression of tumorigenicity 14*ENSMUSG0000003199527
Q8VCA5 / Tmprss4 / Transmembrane protease serine 4 / Q9NRS4* / transmembrane serine protease 4*ENSMUSG0000003209127
Tmprss9 / transmembrane protease, serine 9 / Q7Z410* / transmembrane serine protease 9*ENSMUSG0000005940627
Klkb1 / P26262 / Plasma kallikrein Plasma kallikrein heavy chain Plasma kallikrein light chain / P03952* / kallikrein B1*ENSMUSG0000010976427
Corin / Q9Z319 / Atrial natriuretic peptide-converting enzyme Atrial natriuretic peptide-converting enzyme, N-terminal propeptide Atrial natriuretic peptide-converting enzyme, activated prot...ENSMUSG0000000522026
Q9DBI0 / Tmprss6 / Mus musculus transmembrane serine protease 6 (Tmprss6), transcript variant 2, mRNA. / Q8IU80* / transmembrane serine protease 6*ENSMUSG0000001694226


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR015352  Hepsin, SRCR domain
 IPR017448  SRCR-like domain
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR036772  SRCR-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0008360 regulation of cell shape ISO
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010693 negative regulation of alkaline phosphatase activity IMP
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition ISS
 biological_processGO:0010756 positive regulation of plasminogen activation ISO
 biological_processGO:0030307 positive regulation of cell growth ISS
 biological_processGO:0034769 basement membrane disassembly ISO
 biological_processGO:0042632 cholesterol homeostasis IMP
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0043923 positive regulation by host of viral transcription ISS
 biological_processGO:0050680 negative regulation of epithelial cell proliferation ISS
 biological_processGO:0050910 detection of mechanical stimulus involved in sensory perception of sound IMP
 biological_processGO:0060429 epithelium development IEP
 biological_processGO:0071805 potassium ion transmembrane transport IMP
 biological_processGO:0090103 cochlea morphogenesis IMP
 biological_processGO:0097066 response to thyroid hormone IMP
 biological_processGO:0097195 pilomotor reflex IMP
 biological_processGO:2000347 positive regulation of hepatocyte proliferation ISO
 biological_processGO:2000611 positive regulation of thyroid hormone generation IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0005911 cell-cell junction IMP
 cellular_componentGO:0009986 cell surface ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISO
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031965 nuclear membrane ISS
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity ISO
 molecular_functionGO:0008236 serine-type peptidase activity ISO
 molecular_functionGO:0015269 calcium-activated potassium channel activity IMP
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0070008 serine-type exopeptidase activity IEA


Pathways (from Reactome)
Pathway description
MET Receptor Activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Il7hlb368/Il7hlb368
Genetic Background: C57BL/6J-Il7hlb368/J

Allelic Composition: HpnHlb320/HpnHlb320
Genetic Background: C57BL/6J-HpnHlb320/J

Allelic Composition: HpnHlb320/HpnHlb320
Genetic Background: involves: C57BL/6J * C57L/J

Allelic Composition: HpnHlb320/Hpn+
Genetic Background: involves: C57BL/6J * C57L/J

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Camptm1Rlg/Camp+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: HpnHlb320/HpnHlb320
Genetic Background: C57BL/6J-HpnHlb320/J

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: HpnHlb320/HpnHlb320
Genetic Background: C57BL/6J-HpnHlb320/J

Allelic Composition: HpnHlb320/HpnHlb320
Genetic Background: involves: C57BL/6J * C57L/J

Allelic Composition: HpnHlb320/Hpn+
Genetic Background: involves: C57BL/6J * C57L/J

 MP:0002855 abnormal cochlear ganglion morphology "malformation, malfunction or absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Camptm1Rlg/Camp+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Camptm1Rlg/Camp+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: HpnHlb320/HpnHlb320
Genetic Background: C57BL/6J-HpnHlb320/J

 MP:0003149 abnormal tectorial membrane morphology "malformation, malfunction or absence of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells; sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair cell membrane potential, transducing sound into electrical signals" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]
Show

Allelic Composition: Camptm1Rlg/Camp+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003503 decreased activity of thyroid 
Show

Allelic Composition: Camptm1Rlg/Camp+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004433 abnormal cochlear inner hair cell physiology "anomalies in processes pertinent to the function of cochlear IHCs which constitute the true sensory cell type sending impulses via the cochlear (auditory) nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Camptm1Rlg/Camp+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004434 abnormal cochlear outer hair cell physiology "anomalies in processes pertinent to the function of cochlear OHCs which are known to enhance the performance of the cochlea, both qualitatively (increased selectivity) and quantitatively (increased sensitivity); in addition to the mechanoelectric transduction required for auditory sensation, OHCs also perform electromechanical transduction, whereby transmembrane voltage drives rapid changes in the length and stiffness of OHCs at audio frequencies in vitro (electromotility)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Camptm1Rlg/Camp+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004591 enlarged tectorial membrane "increased size of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Camptm1Rlg/Camp+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Il7hlb368/Il7hlb368
Genetic Background: C57BL/6J-Il7hlb368/J

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: HpnHlb320/HpnHlb320
Genetic Background: C57BL/6J-HpnHlb320/J

Allelic Composition: HpnHlb320/HpnHlb320
Genetic Background: involves: C57BL/6J * C57L/J

Allelic Composition: HpnHlb320/Hpn+
Genetic Background: involves: C57BL/6J * C57L/J

 MP:0005471 decreased thyroxine level "less than the normal concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:13923]
Show

Allelic Composition: Camptm1Rlg/Camp+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Camptm1Rlg/Camp+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: HpnHlb320/HpnHlb320
Genetic Background: C57BL/6J-HpnHlb320/J

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
Show

Allelic Composition: Camptm1Rlg/Camp+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Camptm1Rlg/Camp+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0014091 abnormal tectorial membrane striated-sheet matrix morphology "any structural anomaly of the laminated, striated-sheet matrix within which collagen fibrils of the TM are imbedded; the striated sheet matrix is formed by two types of fine-diameter collagen filaments, a light and a dark staining type that lie in parallel within the plane of each sheet and are extensively linked along their length by staggered cross bridges; it originates medially within the sulcal zone, extends to the marginal band and is particularly evident in apical regions of the cochlea, where it has a less compressed appearance" [PMID:18797289, PMID:24363064]
Show

Allelic Composition: Camptm1Rlg/Camp+
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001249 Hpn / O35453 / Serine protease hepsin Serine protease hepsin non-catalytic chain Serine protease hepsin catalytic chain / hepsin* / P05981*  / complex
 ENSMUSG00000028864 Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*  / reaction






 

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