ENSMUSG00000005696


Mus musculus

Features
Gene ID: ENSMUSG00000005696
  
Biological name :Sh2d1a
  
Synonyms : O88890 / Sh2d1a / SH2 domain-containing protein 1A
  
Possible biological names infered from orthology : O60880 / SH2 domain containing 1A
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A4
Gene start: 42502453
Gene end: 42529330
  
Corresponding Affymetrix probe sets: 10599411 (MoGene1.0st)   10599416 (MoGene1.0st)   1449393_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005839
Ensembl peptide - ENSMUSP00000110722
Ensembl peptide - ENSMUSP00000138624
Ensembl peptide - ENSMUSP00000141070
NCBI entrez gene - 20400     See in Manteia.
MGI - MGI:1328352
RefSeq - XM_017318440
RefSeq - NM_001313688
RefSeq - NM_001313689
RefSeq - NM_011364
RefSeq Peptide - NP_001300618
RefSeq Peptide - NP_035494
RefSeq Peptide - NP_001300617
swissprot - O88890
swissprot - Q544F1
swissprot - S4R2F6
Ensembl - ENSMUSG00000005696
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sh2d1abENSDARG00000074854Danio rerio
 SH2D1AENSGALG00000008447Gallus gallus
 O60880ENSG00000183918Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q45HK4 / Sh2d1b2 / SH2 domain-containing protein 1B2 / SH2D1B* / O14796* / SH2 domain containing 1B*ENSMUSG0000007349435
Sh2d1b1 / SH2 domain containing 1B1 / O14796* / SH2D1B* / SH2 domain containing 1B*ENSMUSG0000010241832


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR017289  SH2 protein 1A
 IPR035876  SH2D1A, SH2 domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006959 humoral immune response IMP
 biological_processGO:0006968 cellular defense response IEA
 biological_processGO:0007267 cell-cell signaling ISO
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity IMP
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Faslpr/Faslpr,Sh2d1arpl/Sh2d1arpl
Genetic Background: MRL/Mp-Faslpr Sh2d1arpl

Allelic Composition: Sh2d1atm1Lyin/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: KitW-v/KitW-v
Genetic Background: involves: CBA/Ca

Allelic Composition: Sh2d1atm1Cpt/Sh2d1atm1Cpt
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sh2d1atm2.1Cpt/Y,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Sh2d1atm2.1Cpt/Sh2d1atm2.1Cpt,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Sh2d1atm1Cpt/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Sh2d1atm1Cpt/Sh2d1atm1Cpt
Genetic Background: C.129S4-Sh2d1atm1Cpt

Allelic Composition: Sh2d1atm1Cpt/Sh2d1atm1Cpt
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Sh2d1atm1Pls/Sh2d1atm1Pls
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Sh2d1atm2.1Cpt/Y,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Sh2d1atm1Cpt/Sh2d1atm1Cpt,Tcra-Jtm1Tgi/Tcra-Jtm1Tgi
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

Allelic Composition: Sh2d1atm2.1Cpt/Sh2d1atm2.1Cpt,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Sh2d1atm1Cpt/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Sh2d1atm1Cpt/Y,Tcra-Jtm1Tgi/Tcra-Jtm1Tgi
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

Allelic Composition: Sh2d1atm1Pls/Y
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Sh2d1atm1Lyin/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: KitW-v/KitW-v
Genetic Background: involves: CBA/Ca

Allelic Composition: Sh2d1atm1Cpt/Sh2d1atm1Cpt
Genetic Background: C.129S4-Sh2d1atm1Cpt

Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Sh2d1atm2.1Vei/Sh2d1atm2.1Vei
Genetic Background: involves: C57BL/6

Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6

Allelic Composition: Sh2d1atm2.1Cpt/Y,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Sh2d1atm2.1Cpt/Sh2d1atm2.1Cpt,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0002406 increased susceptibility to infection "greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

Allelic Composition: Sh2d1atm1Cpt/Sh2d1atm1Cpt
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sh2d1atm1Cpt/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002433 abnormal T helper 1 morphology/development "anomalous structure, formation, or numbers of the subset of helper T cells that enhance cell-mediated immune responses. These cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

 MP:0002434 abnormal T helper 2 morphology/development "anomalous structure, formation, or numbers of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses. These cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Sh2d1atm1Lyin/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sh2d1atm1Cpt/Sh2d1atm1Cpt
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sh2d1atm1Cpt/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Sh2d1atm1Cpt/Sh2d1atm1Cpt
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Sh2d1atm2.1Vei/Sh2d1atm2.1Vei
Genetic Background: involves: C57BL/6

Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6

Allelic Composition: Sh2d1atm1Pls/Sh2d1atm1Pls
Genetic Background: B6.129S6-Sh2d1atm1Pls

Allelic Composition: Sh2d1atm1Vei/Sh2d1atm1Vei
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Sh2d1atm1Cpt/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Sh2d1atm1Lyin/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002499 chronic inflammation "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Sh2d1atm1Lyin/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Slamf1tm1Cpt/Slamf1tm1Cpt,Tg(DO11.10)10Dlo/Tg(DO11.10)10Dlo
Genetic Background: involves: BALB/c * C3H * C57BL/6

Allelic Composition: Sh2d1atm1Cpt/Sh2d1atm1Cpt
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sh2d1atm1Cpt/Sh2d1atm1Cpt
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Sh2d1atm1Cpt/Sh2d1a+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sh2d1atm1Cpt/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sh2d1atm1Cpt/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Sh2d1arpl/Sh2d1arpl
Genetic Background: MRL/Mp-Faslpr Sh2d1arpl

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: KitW-v/KitW-v
Genetic Background: involves: CBA/Ca

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slamf1tm1Cpt/Slamf1tm1Cpt,Tg(DO11.10)10Dlo/Tg(DO11.10)10Dlo
Genetic Background: involves: BALB/c * C3H * C57BL/6

Allelic Composition: Sh2d1atm1Cpt/Sh2d1atm1Cpt
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Sh2d1atm1Cpt/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Usf1tm1Svl/Usf1+,Usf2tm1Svl/Usf2+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6J

Allelic Composition: Sh2d1atm1Cpt/Sh2d1atm1Cpt,Sh2d1b1/Sh2d1b2tm1.1Cpt/Sh2d1b1/Sh2d1b2tm1.1Cpt
Genetic Background: involves: 129S4/SvJae * BALB/cJ

Allelic Composition: Sh2d1atm1Cpt/Sh2d1atm1Cpt
Genetic Background: involves: 129S4/SvJae

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sh2d1atm1Pls/Sh2d1atm1Pls
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Sh2d1atm1Pls/Sh2d1atm1Pls,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Sh2d1atm1Pls/Y
Genetic Background: involves: 129S6/SvEvTac

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
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Allelic Composition: Sh2d1atm1Pls/Sh2d1atm1Pls,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

Allelic Composition: Sh2d1atm1Cpt/Sh2d1atm1Cpt
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sh2d1atm1Cpt/Sh2d1a+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sh2d1atm1Cpt/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sh2d1atm1Pls/Sh2d1atm1Pls
Genetic Background: B6.129S6-Sh2d1atm1Pls

Allelic Composition: Sh2d1atm1Vei/Sh2d1atm1Vei
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Sh2d1atm1Pls/Sh2d1atm1Pls,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Sh2d1atm1Pls/Sh2d1atm1Pls
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Sh2d1atm1Pls/Y
Genetic Background: involves: 129S6/SvEvTac

 MP:0008036 abnormal NK T cell morphology "any structural anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Sh2d1atm1Pls/Sh2d1atm1Pls
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Sh2d1atm1Pls/Y
Genetic Background: involves: 129S6/SvEvTac

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: KitW-v/KitW-v
Genetic Background: involves: CBA/Ca

Allelic Composition: Sh2d1atm1Cpt/Sh2d1atm1Cpt
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sh2d1atm1Cpt/Sh2d1atm1Cpt
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Sh2d1atm2.1Vei/Sh2d1atm2.1Vei
Genetic Background: involves: C57BL/6

Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6

Allelic Composition: Sh2d1atm1Cpt/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sh2d1atm1Cpt/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0008041 absent NK T cells "absence of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: KitW-v/KitW-v
Genetic Background: involves: CBA/Ca

 MP:0008042 abnormal NK T cell physiology "any functional anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Sh2d1atm1Cpt/Sh2d1atm1Cpt
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sh2d1atm1Cpt/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sh2d1atm1.1Knic/Sh2d1atm1.1Knic,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

Allelic Composition: Sh2d1atm1.1Knic/Y,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0008051 abnormal memory T cell physiology "any functional anomaly of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Sh2d1atm1Vei/Sh2d1atm1Vei
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sh2d1atm1Pls/Sh2d1atm1Pls
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Sh2d1atm1Pls/Y
Genetic Background: involves: 129S6/SvEvTac

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Sh2d1atm1Lyin/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008176 abnormal germinal center B cell morphology "any structural anomaly of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sh2d1atm1Cpt/Sh2d1atm1Cpt
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Sh2d1atm1Cpt/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Sh2d1atm1Cpt/Sh2d1atm1Cpt
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Sh2d1atm2.1Vei/Sh2d1atm2.1Vei
Genetic Background: involves: C57BL/6

Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6

Allelic Composition: Sh2d1atm1Cpt/Sh2d1atm1Cpt,Tcra-Jtm1Tgi/Tcra-Jtm1Tgi
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

Allelic Composition: Sh2d1atm1Cpt/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Sh2d1atm1Cpt/Y,Tcra-Jtm1Tgi/Tcra-Jtm1Tgi
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: KitW-v/KitW-v
Genetic Background: involves: CBA/Ca

 MP:0008192 abnormal germinal center B cell physiology "abnormal function of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Sh2d1atm1Cpt/Sh2d1atm1Cpt
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sh2d1atm2.1Cpt/Y,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Sh2d1atm2.1Cpt/Sh2d1atm2.1Cpt,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Sh2d1atm1Cpt/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Sh2d1atm1Cpt/Sh2d1atm1Cpt
Genetic Background: C.129S4-Sh2d1atm1Cpt

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: KitW-v/KitW-v
Genetic Background: involves: CBA/Ca

Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Sh2d1atm2.1Vei/Sh2d1atm2.1Vei
Genetic Background: involves: C57BL/6

Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Sh2d1atm2.1Vei/Sh2d1atm2.1Vei
Genetic Background: involves: C57BL/6

Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Sh2d1atm2.1Vei/Sh2d1atm2.1Vei
Genetic Background: involves: C57BL/6

Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Sh2d1atm2.1Vei/Sh2d1atm2.1Vei
Genetic Background: involves: C57BL/6

Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: KitW-v/KitW-v
Genetic Background: involves: CBA/Ca

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Sh2d1atm1Pls/Sh2d1atm1Pls
Genetic Background: B6.129S6-Sh2d1atm1Pls

Allelic Composition: Sh2d1atm1Vei/Sh2d1atm1Vei
Genetic Background: B6.129-Sh2d1atm1Vei

Allelic Composition: Sh2d1atm1Pls/Sh2d1atm1Pls,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Sh2d1atm1.1Knic/Sh2d1atm1.1Knic,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

Allelic Composition: Sh2d1atm1.1Knic/Y,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0008603 decreased circulating interleukin-4 level "reduction in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Sh2d1atm1.1Knic/Sh2d1atm1.1Knic,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

Allelic Composition: Sh2d1atm1.1Knic/Y,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0009058 decreased interleukin-21 secretion "reduction in the production or release of a pleiotropic cytokine that regulates immunoglobulin production, plasma cell and Th17 T cell differentiation, CD8+ T cell expansion, and inhibits antigen presentation by dendritic cells" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Sh2d1atm1Pls/Sh2d1atm1Pls
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Sh2d1atm1Pls/Y
Genetic Background: involves: 129S6/SvEvTac

 MP:0010084 abnormal long lived plasma cell morphology "any structural anomaly of a fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive; the majority of these cells of this type reside in the bone marrow" [CL:0000974]
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Allelic Composition: Sh2d1atm1Pls/Sh2d1atm1Pls
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Sh2d1atm1Pls/Y
Genetic Background: involves: 129S6/SvEvTac

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Sh2d1atm1Pls/Sh2d1atm1Pls
Genetic Background: B6.129S6-Sh2d1atm1Pls

Allelic Composition: Sh2d1atm1Vei/Sh2d1atm1Vei
Genetic Background: B6.129-Sh2d1atm1Vei

Allelic Composition: Sh2d1atm1Vei/Sh2d1atm1Vei,Sh2d1b1tm3Vei/Sh2d1b1tm3Vei
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Sh2d1atm1Pls/Sh2d1atm1Pls,Sh2d1b1tm3Vei/Sh2d1b1tm3Vei
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015314 Q9ET39 / Slamf6 / SLAM family member 6 / Q96DU3*  / complex / reaction






 

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