Manteia - Molecule gene

ENSMUSG00000073494

Mus musculus

Features

Gene ID:	ENSMUSG00000073494

Biological name :	Sh2d1b2

Synonyms :	Q45HK4 / Sh2d1b2 / SH2 domain-containing protein 1B2

Possible biological names infered from orthology :	O14796 / SH2D1B / SH2 domain containing 1B

Species:	Mus musculus

Chr. number:	1
Strand:	1
Band:	H3
Gene start:	170232749
Gene end:	170253608

Corresponding Affymetrix probe sets:	10351473 (MoGene1.0st) 1423024_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000125121 Ensembl peptide - ENSMUSP00000137939 NCBI entrez gene - 545378 See in Manteia. MGI - MGI:3622649 RefSeq - NM_001033499 RefSeq Peptide - NP_001028671 swissprot - M0QWP8 swissprot - Q45HK4 Ensembl - ENSMUSG00000073494

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
si:ch73-264p11.1	ENSDARG00000091835	Danio rerio
SH2D1B	ENSGALG00000028448	Gallus gallus
O14796	ENSG00000198574	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Sh2d1b1 / SH2 domain containing 1B1 / O14796* / SH2D1B* / SH2 domain containing 1B*	ENSMUSG00000102418	82
O88890 / Sh2d1a / SH2 domain-containing protein 1A / O60880* / SH2 domain containing 1A*	ENSMUSG00000005696	33

Protein motifs (from Interpro)

Interpro ID	Name
IPR000980	SH2 domain
IPR035049	EAT-2, SH2 domain
IPR036860	SH2 domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002250	adaptive immune response	IEA
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA
biological_process	GO:0032814	regulation of natural killer cell activation	IGI
biological_process	GO:0045087	innate immune response	IEA
biological_process	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	IMP
biological_process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	IGI
biological_process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA
cellular_component	GO:0005575	cellular_component	ND
cellular_component	GO:0005737	cytoplasm	IEA
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0003080	competent NK cell cytolysis	"ability of these cells to destroy or dissolve targeted cells" [RGD:Rat Genome Database submission]	Show Allelic Composition: Usf1^tm1Svl/Usf1⁺,Usf2^tm1Svl/Usf2⁺ Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6J
MP:0005070	defective NK cell cytolysis	"impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]	Show Allelic Composition: Usf1^tm1Svl/Usf1⁺,Usf2^tm1Svl/Usf2⁺ Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6J Allelic Composition: Sh2d1b1^tm2Vei/Sh2d1b1^tm2Vei,Sh2d1b2^tm1Vei/Sh2d1b2^tm1Vei Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Sh2d1b2^tm1.1Cpt/Sh2d1b2^tm1.1Cpt Genetic Background: involves: BALB/cJ * C57BL/6 Allelic Composition: Sh2d1b1/Sh2d1b2^tm1.1Cpt/Sh2d1b1/Sh2d1b2^tm1.1Cpt Genetic Background: involves: BALB/cJ Allelic Composition: Sh2d1a^tm1Cpt/Sh2d1a^tm1Cpt,Sh2d1b1/Sh2d1b2^tm1.1Cpt/Sh2d1b1/Sh2d1b2^tm1.1Cpt Genetic Background: involves: 129S4/SvJae * BALB/cJ
MP:0008567	decreased interferon-gamma secretion	"reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Sh2d1b1/Sh2d1b2^tm1.1Cpt/Sh2d1b1/Sh2d1b2^tm1.1Cpt Genetic Background: involves: BALB/cJ

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000015314	Q9ET39 / Slamf6 / SLAM family member 6 / Q96DU3*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr