ENSMUSG00000005980


Mus musculus

Features
Gene ID: ENSMUSG00000005980
  
Biological name :Dnase1
  
Synonyms : Dnase1 / Mus musculus deoxyribonuclease I (Dnase1), transcript variant 2, mRNA. / P49183
  
Possible biological names infered from orthology : deoxyribonuclease 1 / P24855
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A1
Gene start: 4036942
Gene end: 4040024
  
Corresponding Affymetrix probe sets: 10433241 (MoGene1.0st)   1424592_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135060
Ensembl peptide - ENSMUSP00000120642
Ensembl peptide - ENSMUSP00000135442
Ensembl peptide - ENSMUSP00000006136
Ensembl peptide - ENSMUSP00000113119
Ensembl peptide - ENSMUSP00000119934
NCBI entrez gene - 13419     See in Manteia.
MGI - MGI:103157
RefSeq - XM_006521776
RefSeq - NM_001357143
RefSeq - NM_010061
RefSeq - XM_006521774
RefSeq - XM_006521775
RefSeq Peptide - NP_034191
RefSeq Peptide - NP_001344072
swissprot - H3BJN9
swissprot - H3BKL7
swissprot - E9Q797
swissprot - D3YXC7
swissprot - Q14BW6
swissprot - P49183
Ensembl - ENSMUSG00000005980
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnase1ENSDARG00000012539Danio rerio
 DNASE1ENSG00000213918Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9D1G0 / Dnase1l2 / Deoxyribonuclease-1-like 2 / Q92874*ENSMUSG0000002413651
O55070 / Dnase1l3 / Deoxyribonuclease gamma / Q13609* / deoxyribonuclease 1 like 3*ENSMUSG0000002527946
Q9D7J6 / Dnase1l1 / Deoxyribonuclease-1-like 1 / P49184*ENSMUSG0000001908839


Protein motifs (from Interpro)
Interpro ID Name
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR016202  Deoxyribonuclease I
 IPR018057  Deoxyribonuclease I, active site
 IPR033125  Deoxyribonuclease I, conservied site
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000737 DNA catabolic process, endonucleolytic IDA
 biological_processGO:0002283 neutrophil activation involved in immune response IDA
 biological_processGO:0002673 regulation of acute inflammatory response IDA
 biological_processGO:0006308 DNA catabolic process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0070948 regulation of neutrophil mediated cytotoxicity IDA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005635 nuclear envelope IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004530 deoxyribonuclease I activity IMP
 molecular_functionGO:0004536 deoxyribonuclease activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004154 renal tubular necrosis "pathological cell death in the proximal and/or distal renal tubules, usually due to irreversible damage " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004802 decreased susceptibility to systemic lupus erythematosus "reduced likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011371 decreased kidney apoptosis "decrease in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr