ENSMUSG00000005980


Mus musculus

Features
Gene ID: ENSMUSG00000005980
  
Biological name :Dnase1
  
Synonyms : Dnase1 / Mus musculus deoxyribonuclease I (Dnase1), transcript variant 2, mRNA. / P49183
  
Possible biological names infered from orthology : deoxyribonuclease 1 / P24855
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A1
Gene start: 4036942
Gene end: 4040024
  
Corresponding Affymetrix probe sets: 10433241 (MoGene1.0st)   1424592_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135060
Ensembl peptide - ENSMUSP00000120642
Ensembl peptide - ENSMUSP00000135442
Ensembl peptide - ENSMUSP00000006136
Ensembl peptide - ENSMUSP00000113119
Ensembl peptide - ENSMUSP00000119934
NCBI entrez gene - 13419     See in Manteia.
MGI - MGI:103157
RefSeq - XM_006521776
RefSeq - NM_001357143
RefSeq - NM_010061
RefSeq - XM_006521774
RefSeq - XM_006521775
RefSeq Peptide - NP_034191
RefSeq Peptide - NP_001344072
swissprot - H3BJN9
swissprot - H3BKL7
swissprot - E9Q797
swissprot - D3YXC7
swissprot - Q14BW6
swissprot - P49183
Ensembl - ENSMUSG00000005980
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnase1ENSDARG00000012539Danio rerio
 DNASE1ENSG00000213918Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9D1G0 / Dnase1l2 / Deoxyribonuclease-1-like 2 / Q92874*ENSMUSG0000002413651
O55070 / Dnase1l3 / Deoxyribonuclease gamma / Q13609* / deoxyribonuclease 1 like 3*ENSMUSG0000002527946
Q9D7J6 / Dnase1l1 / Deoxyribonuclease-1-like 1 / P49184*ENSMUSG0000001908839


Protein motifs (from Interpro)
Interpro ID Name
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR016202  Deoxyribonuclease I
 IPR018057  Deoxyribonuclease I, active site
 IPR033125  Deoxyribonuclease I, conservied site
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000737 DNA catabolic process, endonucleolytic IDA
 biological_processGO:0002283 neutrophil activation involved in immune response IDA
 biological_processGO:0002673 regulation of acute inflammatory response IDA
 biological_processGO:0006308 DNA catabolic process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0070948 regulation of neutrophil mediated cytotoxicity IDA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005635 nuclear envelope IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004530 deoxyribonuclease I activity IMP
 molecular_functionGO:0004536 deoxyribonuclease activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004154 renal tubular necrosis "pathological cell death in the proximal and/or distal renal tubules, usually due to irreversible damage " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004802 decreased susceptibility to systemic lupus erythematosus "reduced likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011371 decreased kidney apoptosis "decrease in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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