ENSMUSG00000006014


Mus musculus

Features
Gene ID: ENSMUSG00000006014
  
Biological name :Prg4
  
Synonyms : Prg4 / proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
  
Possible biological names infered from orthology : proteoglycan 4 / Q92954
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: G1
Gene start: 150449412
Gene end: 150466165
  
Corresponding Affymetrix probe sets: 10358476 (MoGene1.0st)   1449824_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107532
Ensembl peptide - ENSMUSP00000128943
Ensembl peptide - ENSMUSP00000125677
Ensembl peptide - ENSMUSP00000125551
Ensembl peptide - ENSMUSP00000124801
Ensembl peptide - ENSMUSP00000124410
Ensembl peptide - ENSMUSP00000107533
Ensembl peptide - ENSMUSP00000006171
NCBI entrez gene - 96875     See in Manteia.
MGI - MGI:1891344
RefSeq - XM_017313032
RefSeq - NM_001110146
RefSeq - NM_021400
RefSeq - XM_006529963
RefSeq - XM_006529966
RefSeq Peptide - NP_067375
RefSeq Peptide - NP_001103616
swissprot - E0CZ58
swissprot - E0CY90
swissprot - E0CXA1
swissprot - E9QQ17
swissprot - A0A0R4J207
swissprot - E9QQ18
Ensembl - ENSMUSG00000006014
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prg4aENSDARG00000010482Danio rerio
 prg4bENSDARG00000028163Danio rerio
 PRG4ENSG00000116690Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vtn / P29788 / vitronectin / P04004*ENSMUSG0000001734410


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001212  Somatomedin B domain
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR020436  Somatomedin B, chordata
 IPR036024  Somatomedin B-like domain superfamily
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006955 immune response IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0030247 polysaccharide binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000167 reduced chondrocyte numbers "fewer than normal numbers of nondividing cartilage cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61509]
Show

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1tm4Wbm,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1tm4Wbm,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

Allelic Composition: Prg4tm1(GFP/cre/ERT2)Abl/Prg4tm1(GFP/cre/ERT2)Abl
Genetic Background: involves: 129 * C57BL/6J

 MP:0002936 joint swelling "enlargement of the joints, usually due to an accumulation of fluid" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1tm4Wbm,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1tm4Wbm,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0003200 joint calcification "pathologic deposition of calcium salts in the joints" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1tm4Wbm,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0003807 camptodactyly "permanant flexion of one or more digits; contractures may also be seen in the wrists and at the elbows" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1tm4Wbm,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sult1a1tm1Glatt/Sult1a1tm1Glatt,Tg(SULT1A1,SULT1A2)1Glatt/0
Genetic Background: FVB.Cg-Sult1a1tm1Glatt Tg(SULT1A1,SULT1A2)1Glatt

 MP:0006433 abnormal articular cartilage morphology "any structural anomaly of the thin layer of smooth hyaline cartilage located on the joint surfaces of a bone" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1tm4Wbm,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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