ENSMUSG00000017344


Mus musculus

Features
Gene ID: ENSMUSG00000017344
  
Biological name :Vtn
  
Synonyms : P29788 / vitronectin / Vtn
  
Possible biological names infered from orthology : P04004
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 78499091
Gene end: 78502324
  
Corresponding Affymetrix probe sets: 10379190 (MoGene1.0st)   1420484_a_at (Mouse Genome 430 2.0 Array)   1455098_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000017488
NCBI entrez gene - 22370     See in Manteia.
MGI - MGI:98940
RefSeq - NM_011707
RefSeq Peptide - NP_035837
swissprot - P29788
Ensembl - ENSMUSG00000017344
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vtnaENSDARG00000055388Danio rerio
 vtnbENSDARG00000053831Danio rerio
 VTNENSGALG00000003589Gallus gallus
 VTNENSG00000109072Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prg4 / proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) / Q92954* / proteoglycan 4*ENSMUSG0000000601426


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001212  Somatomedin B domain
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR020436  Somatomedin B, chordata
 IPR036024  Somatomedin B-like domain superfamily
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IDA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030198 extracellular matrix organization IDA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0033627 cell adhesion mediated by integrin IEA
 biological_processGO:0035987 endodermal cell differentiation IEA
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis IEA
 biological_processGO:0048709 oligodendrocyte differentiation IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051258 protein polymerization IEA
 biological_processGO:0061302 smooth muscle cell-matrix adhesion IEA
 biological_processGO:0097421 liver regeneration IEA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005796 Golgi lumen IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048237 rough endoplasmic reticulum lumen IEA
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0030247 polysaccharide binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0050840 extracellular matrix binding IDA


Pathways (from Reactome)
Pathway description
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
ECM proteoglycans
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxc4tm1Hsu/Hoxc4tm1Hsu
Genetic Background: involves: 129S/SvEv * A/J

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxc4tm1Hsu/Hoxc4tm1Hsu
Genetic Background: involves: 129S/SvEv * A/J

 MP:0009548 abnormal platelet aggregation "any functional anomaly in the adhesion of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
Show

Allelic Composition: Hoxc4tm1Hsu/Hoxc4tm1Hsu
Genetic Background: involves: 129S/SvEv * A/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015083 C8g / Q8VCG4 / Complement component C8 gamma chain / P07360* / complement C8 gamma chain*  / complex / reaction
 ENSMUSG00000029675 Eln / P54320 / Elastin / P15502*  / complex / reaction
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / complex / reaction
 ENSMUSG00000026874 Hc / P06684 / hemolytic complement / C5* / P01031* / complement C5*  / complex / reaction
 ENSMUSG00000024598 Fbn2 / Q61555 / Fibrillin-2 Fibrillin-2 C-terminal peptide / P35556* / fibrillin 2*  / complex / reaction
 ENSMUSG00000025321 Itgb8 / integrin subunit beta 8 / P26012*  / complex / reaction
 ENSMUSG00000022181 C6 / complement component 6 / P13671* / complement C6*  / complex / reaction
 ENSMUSG00000027087 Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*  / complex / reaction
 ENSMUSG00000030116 Mfap5 / Q9QZJ6 / Microfibrillar-associated protein 5 / Q13361* / microfibril associated protein 5*  / complex / reaction
 ENSMUSG00000027204 Fbn1 / Q61554 / Fibrillin-1 Asprosin / P35555* / fibrillin 1*  / complex / reaction
 ENSMUSG00000029163 Q99K41 / Emilin1 / Q9Y6C2* / elastin microfibril interfacer 1*  / complex / reaction
 ENSMUSG00000060572 Mfap2 / microfibril associated protein 2 / P55001*  / complex / reaction
 ENSMUSG00000022817 Itgb5 / integrin subunit beta 5 / P18084*  / complex / reaction
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex / reaction
 ENSMUSG00000034664 Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*  / complex / reaction
 ENSMUSG00000079105 C7 / complement component 7 / P10643* / complement C7*  / complex / reaction
 ENSMUSG00000022149 C9 / complement C9 / P02748*  / complex / reaction
 ENSMUSG00000029656 C8b / Q8BH35 / Complement component C8 beta chain / P07358* / complement C8 beta chain*  / complex / reaction
 ENSMUSG00000037411 Serpine1 / serine (or cysteine) peptidase inhibitor, clade E, member 1 / P05121* / serpin family E member 1*  / complex / reaction
 ENSMUSG00000035031 C8a / Q8K182 / Complement component C8 alpha chain / P07357* / complement C8 alpha chain*  / complex / reaction






 

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