ENSMUSG00000006344


Mus musculus

Features
Gene ID: ENSMUSG00000006344
  
Biological name :Ggt5
  
Synonyms : Ggt5 / Glutathione hydrolase 5 proenzyme Glutathione hydrolase 5 heavy chain Glutathione hydrolase 5 light chain / Q9Z2A9
  
Possible biological names infered from orthology : gamma-glutamyltransferase 5 / P36269
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 75589340
Gene end: 75617200
  
Corresponding Affymetrix probe sets: 10364072 (MoGene1.0st)   1418216_at (Mouse Genome 430 2.0 Array)   1439420_x_at (Mouse Genome 430 2.0 Array)   1455747_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141106
Ensembl peptide - ENSMUSP00000151283
Ensembl peptide - ENSMUSP00000072074
Ensembl peptide - ENSMUSP00000139459
NCBI entrez gene - 23887     See in Manteia.
MGI - MGI:1346063
RefSeq - NM_011820
RefSeq - XM_006513647
RefSeq - XM_006513649
RefSeq Peptide - NP_035950
swissprot - Q80WV0
swissprot - A0A087WNR3
swissprot - A0A087WSM3
swissprot - Q9Z2A9
Ensembl - ENSMUSG00000006344
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01049847.1ENSDARG00000078258Danio rerio
 ggt5aENSDARG00000052045Danio rerio
 GGT5ENSGALG00000040504Gallus gallus
 GGT5ENSG00000099998Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ggt1 / Q60928 / Glutathione hydrolase 1 proenzyme Glutathione hydrolase 1 heavy chain Glutathione hydrolase 1 light chain / GGT2* / Q9BX51* / GGTLC3* / P19440* / P36268* / Q14390* / B5MD39*...ENSMUSG0000000634539
Ggt7 / Q99JP7 / Glutathione hydrolase 7 Glutathione hydrolase 7 heavy chain Glutathione hydrolase 7 light chain / Q9UJ14* / gamma-glutamyltransferase 7*ENSMUSG0000002760327
Ggt6 / Q6PDE7 / Glutathione hydrolase 6 Glutathione hydrolase 6 heavy chain Glutathione hydrolase 6 light chain / Q6P531* / gamma-glutamyltransferase 6*ENSMUSG0000004047119


Protein motifs (from Interpro)
Interpro ID Name
 IPR000101  Gamma-glutamyltranspeptidase
 IPR029055  Nucleophile aminohydrolases, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006520 cellular amino acid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006749 glutathione metabolic process IEA
 biological_processGO:0006750 glutathione biosynthetic process IEA
 biological_processGO:0006751 glutathione catabolic process IEA
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0019370 leukotriene biosynthetic process IEA
 biological_processGO:1901750 leukotriene D4 biosynthetic process IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane IEA
 molecular_functionGO:0000048 peptidyltransferase activity IEA
 molecular_functionGO:0002951 leukotriene-C(4) hydrolase IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036374 glutathione hydrolase activity IEA
 molecular_functionGO:0102953 hypoglycin A gamma-glutamyl transpeptidase activity IEA
 molecular_functionGO:0103068 leukotriene C4 gamma-glutamyl transferase activity IEA


Pathways (from Reactome)
Pathway description
Glutathione synthesis and recycling
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Aflatoxin activation and detoxification


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Ggt1tm1Zuk/Ggt1tm1Zuk,Ggt5tm1Mwl/Ggt5tm1Mwl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ggt1tm1Zuk/Ggt1tm1Zuk,Ggt5tm1Mwl/Ggt5tm1Mwl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Ggt1tm1Zuk/Ggt1tm1Zuk,Ggt5tm1Mwl/Ggt5tm1Mwl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001937 abnormal sexual maturation "a delay or a block in the development of the sexual organs at a given age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ggt1tm1Zuk/Ggt1tm1Zuk,Ggt5tm1Mwl/Ggt5tm1Mwl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hgftm1Cbm/Hgf+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ggt1tm1Zuk/Ggt1tm1Zuk,Ggt5tm1Mwl/Ggt5tm1Mwl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
Show

Allelic Composition: Hgftm1Cbm/Hgf+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006344 Ggt5 / Q9Z2A9 / Glutathione hydrolase 5 proenzyme Glutathione hydrolase 5 heavy chain Glutathione hydrolase 5 light chain / P36269* / gamma-glutamyltransferase 5*  / complex






 

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