MP:0000208 | decreased hematocrit | "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Mplhlb219/Mplhlb219 Genetic Background: C57BL/6J-Mplhlb219/J
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MP:0000218 | increased WBC count | "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Plt8/Suz12+ Genetic Background: B6.Cg-Mpltm1Wsa Suz12Plt8
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Gt(Betageo)1Khe/Suz12+ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
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MP:0000221 | decreased WBC count | "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gbatm2Ggb/Gbatm1Nsb Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/MybPlt4 Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Ergmld2/Erg+,Mpltm1Wsa/Mpltm1Wsa Genetic Background: B6.Cg-Mpltm1Wsa Ergmld2
Allelic Composition: Lynmld4/Lynmld4,Mpltm1Wsa/Mpltm1Wsa Genetic Background: B6.129S1-Mpltm1Wsa
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MP:0000228 | abnormal thrombopoiesis | "abnormal development of the non-nucleated cells of the blood (platelets, thrombocytes) involved in blood coagulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/MybPlt3 Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/Myb+ Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/MybPlt4 Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/Myb+ Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Plt8/Suz12+ Genetic Background: B6.Cg-Mpltm1Wsa Suz12Plt8
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Gt(Betageo)1Khe/Suz12+ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
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MP:0000229 | abnormal megakaryocyte differentiation | "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/MybPlt3 Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/Myb+ Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/MybPlt4 Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/Myb+ Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Plt8/Suz12+ Genetic Background: B6.Cg-Mpltm1Wsa Suz12Plt8
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MP:0000245 | abnormal erythropoiesis | "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/MybPlt3 Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/MybPlt4 Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0000689 | abnormal spleen morphology | "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463] |
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Allelic Composition: Adarb1tm1Phs/Adarb1tm1Phs,Gria2tm1.1Phs/Gria2+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/MybPlt4 Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0000691 | enlarged spleen | "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gbatm2Ggb/Gbatm1Nsb Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6
Allelic Composition: Mpltm2.1Wsa/Mpltm2.1Wsa,Tg(Pf4-icre)Q3Rsko/0 Genetic Background: involves: C57BL/6
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MP:0001577 | anemia | "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Gbatm2Ggb/Gbatm1Nsb Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/MybPlt3 Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/MybPlt4 Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Ergmld2/Erg+,Mpltm1Wsa/Mpltm1Wsa Genetic Background: B6.Cg-Mpltm1Wsa Ergmld2
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MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
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Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Plt8/Suz12Plt8 Genetic Background: B6.Cg-Mpltm1Wsa Suz12Plt8
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MP:0002082 | postnatal lethality | "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Leprdb-2J/Leprdb-2J Genetic Background: involves: C57BL/6J * STOCK Tyrp1b Whrnwi
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MP:0002123 | abnormal hematopoiesis | "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gbatm2Ggb/Gbatm1Nsb Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6
Allelic Composition: Mpltm1Fjs/Mpltm1Fjs Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/MybPlt3 Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/Myb+ Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/MybPlt4 Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/Myb+ Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mplhlb219/Mpl+ Genetic Background: C57BL/6J-Mplhlb219/J
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MP:0002144 | abnormal B lymphocyte development | "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/MybPlt3 Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0002398 | abnormal bone marrow cell morphology/development | "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Faslpr/Faslpr Genetic Background: C3.MRL-Faslpr/J
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MP:0002413 | abnormal megakaryoblast morphology/development | "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Cdkn2dtm1Maro/Cdkn2dtm1Maro Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Allelic Composition: Mplhlb219/Mplhlb219 Genetic Background: C57BL/6J-Mplhlb219/J
Allelic Composition: Mpltm1Fjs/Mpltm1Fjs Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Ep300Plt6/Ep300Plt6,Mpltm1Wsa/Mpltm1Wsa Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Ep300Plt6/Ep300+,Mpltm1Wsa/Mpltm1Wsa Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0002417 | abnormal megakaryocyte morphology/development | "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mpltm2.1Wsa/Mpltm2.1Wsa,Tg(Pf4-icre)Q3Rsko/0 Genetic Background: involves: C57BL/6
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MP:0002599 | increased mean platelet volume | "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator] |
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Allelic Composition: Ceacam9tm1Wzm/Ceacam9tm1Wzm Genetic Background: either: (involves: 129/Sv * BALB/cJ) or (involves: BALB/cJ)
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MP:0002874 | decreased hemoglobin content | "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mplhlb219/Mplhlb219 Genetic Background: C57BL/6J-Mplhlb219/J
Allelic Composition: Mplhlb219/Mpl+ Genetic Background: C57BL/6J-Mplhlb219/J
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MP:0002875 | decreased erythrocyte count | "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mplhlb219/Mplhlb219 Genetic Background: C57BL/6J-Mplhlb219/J
Allelic Composition: Lynmld4/Lynmld4,Mpltm1Wsa/Mpltm1Wsa Genetic Background: B6.129S1-Mpltm1Wsa
Allelic Composition: Mplhlb219/Mpl+ Genetic Background: C57BL/6J-Mplhlb219/J
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MP:0003179 | decreased platelet count | "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052] |
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Allelic Composition: Ceacam9tm1Wzm/Ceacam9tm1Wzm Genetic Background: either: (involves: 129/Sv * BALB/cJ) or (involves: BALB/cJ)
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mplhlb219/Mplhlb219 Genetic Background: C57BL/6J-Mplhlb219/J
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Plt8/Suz12+ Genetic Background: B6.Cg-Mpltm1Wsa Suz12Plt8
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Gt(Betageo)1Khe/Suz12+ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Allelic Composition: Ergmld2/Erg+,Mpltm1Wsa/Mpltm1Wsa Genetic Background: B6.Cg-Mpltm1Wsa Ergmld2
Allelic Composition: Fli1tm1Dkw/Fli1+,Mpltm1Wsa/Mpltm1Wsa Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6
Allelic Composition: Lynmld4/Lynmld4,Mpltm1Wsa/Mpltm1Wsa Genetic Background: B6.129S1-Mpltm1Wsa
Allelic Composition: Mpltm2.2Wsa/Mpltm2.2Wsa Genetic Background: involves: BALB/cJ * C57BL/6
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MP:0004720 | abnormal platelet morphology | "any structural anomaly of blood plasma cells derived from megakaryocytes, which function to promote blood clotting" [MESH:National Library of Medicine_Medical Subject Headings] |
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Allelic Composition: Ep300Plt6/Ep300+,Mpltm1Wsa/Mpltm1Wsa Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0004810 | decreased hematopoietic stem cell number | "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mpltm1Wsa/Mpltm1Wsa Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0005011 | increased eosinophil count | "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ep300Plt6/Ep300+,Mpltm1Wsa/Mpltm1Wsa Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0005013 | increased lymphocyte number | "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Plt8/Suz12+ Genetic Background: B6.Cg-Mpltm1Wsa Suz12Plt8
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Gt(Betageo)1Khe/Suz12+ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
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MP:0005505 | increased platelet count | "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/MybPlt3 Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/Myb+ Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/MybPlt4 Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/Myb+ Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Ep300Plt6/Ep300Plt6,Mpltm1Wsa/Mpltm1Wsa Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mplhlb219/Mpl+ Genetic Background: C57BL/6J-Mplhlb219/J
Allelic Composition: Mpltm2.1Wsa/Mpltm2.1Wsa,Tg(Pf4-icre)Q3Rsko/0 Genetic Background: involves: C57BL/6
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MP:0005606 | increased bleeding time | "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Mplhlb219/Mplhlb219 Genetic Background: C57BL/6J-Mplhlb219/J
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MP:0006410 | abnormal common myeloid progenitor cell morphology | "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mpltm2.1Wsa/Mpltm2.1Wsa,Tg(Pf4-icre)Q3Rsko/0 Genetic Background: involves: C57BL/6
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MP:0008253 | absent megakaryocytes | "absence of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464] |
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Allelic Composition: Ceacam9tm1Wzm/Ceacam9tm1Wzm Genetic Background: either: (involves: 129/Sv * BALB/cJ) or (involves: BALB/cJ)
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0008254 | increased megakaryocyte cell number | "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464] |
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Allelic Composition: Ep300Plt6/Ep300Plt6,Mpltm1Wsa/Mpltm1Wsa Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Ep300Plt6/Ep300+,Mpltm1Wsa/Mpltm1Wsa Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mpltm2.1Wsa/Mpltm2.1Wsa,Tg(Pf4-icre)Q3Rsko/0 Genetic Background: involves: C57BL/6
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MP:0008255 | decreased megakaryocyte cell number | "reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464] |
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Allelic Composition: Mplhlb219/Mplhlb219 Genetic Background: C57BL/6J-Mplhlb219/J
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MP:0008470 | abnormal spleen B cell follicle morphology | "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967] |
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Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/MybPlt3 Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/MybPlt4 Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0008476 | increased spleen red pulp amount | "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/MybPlt3 Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/MybPlt4 Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0008813 | decreased common myeloid progenitor cell number | "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mplhlb219/Mplhlb219 Genetic Background: C57BL/6J-Mplhlb219/J
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MP:0008973 | decreased erythroid progenitor cell number | "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mpltm2.1Wsa/Mpltm2.1Wsa,Tg(Pf4-icre)Q3Rsko/0 Genetic Background: involves: C57BL/6
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MP:0010209 | abnormal circulating chemokine level | "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mpltm1Wsa/Mpltm1Wsa Genetic Background: involves: 129S1/Sv
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MP:0010210 | abnormal circulating cytokine level | "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mplhlb219/Mplhlb219 Genetic Background: C57BL/6J-Mplhlb219/J
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MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/MybPlt3 Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0011091 | complete prenatal lethality | "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Plt8/Suz12Plt8 Genetic Background: B6.Cg-Mpltm1Wsa Suz12Plt8
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MP:0011902 | increased hematopoietic stem cell proliferation | "increase in the expansion rate of a hematopoietic stem cell population by cell division" [MGI:csmith] |
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Allelic Composition: Mpltm2.1Wsa/Mpltm2.1Wsa,Tg(Pf4-icre)Q3Rsko/0 Genetic Background: involves: C57BL/6
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