ENSMUSG00000006389


Mus musculus

Features
Gene ID: ENSMUSG00000006389
  
Biological name :Mpl
  
Synonyms : Mpl / Q08351 / Thrombopoietin receptor
  
Possible biological names infered from orthology : MPL proto-oncogene, thrombopoietin receptor / P40238
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.1
Gene start: 118442415
Gene end: 118457513
  
Corresponding Affymetrix probe sets: 10515755 (MoGene1.0st)   1421461_at (Mouse Genome 430 2.0 Array)   1451919_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130167
Ensembl peptide - ENSMUSP00000006556
Ensembl peptide - ENSMUSP00000099732
Ensembl peptide - ENSMUSP00000101983
NCBI entrez gene - 17480     See in Manteia.
MGI - MGI:97076
RefSeq - XM_011240468
RefSeq - NM_001122949
RefSeq - NM_001285496
RefSeq - NM_001285497
RefSeq - NM_010823
RefSeq Peptide - NP_001116421
RefSeq Peptide - NP_034953
RefSeq Peptide - NP_001272425
RefSeq Peptide - NP_001272426
swissprot - Q925F5
swissprot - E9Q7U5
swissprot - Q08351
swissprot - A2A9D4
Ensembl - ENSMUSG00000006389
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mplENSDARG00000039222Danio rerio
 MPLENSGALG00000009965Gallus gallus
 MPLENSG00000117400Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Epor / P14753 / Erythropoietin receptor / P19235*ENSMUSG0000000623511


Protein motifs (from Interpro)
Interpro ID Name
 IPR003528  Long hematopoietin receptor, single chain, conserved site
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR015152  Growth hormone/erythropoietin receptor, ligand binding
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001780 neutrophil homeostasis IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0030220 platelet formation IGI
 biological_processGO:0032642 regulation of chemokine production IMP
 biological_processGO:0035702 monocyte homeostasis IEA
 biological_processGO:0038163 thrombopoietin-mediated signaling pathway IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0048872 homeostasis of number of cells IMP
 biological_processGO:0050671 positive regulation of lymphocyte proliferation IEA
 biological_processGO:0060216 definitive hemopoiesis IMP
 biological_processGO:0070527 platelet aggregation IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0072091 regulation of stem cell proliferation IMP
 biological_processGO:1905221 positive regulation of platelet formation IEA
 biological_processGO:1990959 eosinophil homeostasis IEA
 biological_processGO:1990960 basophil homeostasis IEA
 biological_processGO:2000035 regulation of stem cell division IMP
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0038164 thrombopoietin receptor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mplhlb219/Mplhlb219
Genetic Background: C57BL/6J-Mplhlb219/J

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Plt8/Suz12+
Genetic Background: B6.Cg-Mpltm1Wsa Suz12Plt8

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gbatm2Ggb/Gbatm1Nsb
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/MybPlt4
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ergmld2/Erg+,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: B6.Cg-Mpltm1Wsa Ergmld2

Allelic Composition: Lynmld4/Lynmld4,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: B6.129S1-Mpltm1Wsa

 MP:0000228 abnormal thrombopoiesis "abnormal development of the non-nucleated cells of the blood (platelets, thrombocytes) involved in blood coagulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/MybPlt3
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/Myb+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/MybPlt4
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/Myb+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Plt8/Suz12+
Genetic Background: B6.Cg-Mpltm1Wsa Suz12Plt8

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0000229 abnormal megakaryocyte differentiation "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/MybPlt3
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/Myb+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/MybPlt4
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/Myb+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Plt8/Suz12+
Genetic Background: B6.Cg-Mpltm1Wsa Suz12Plt8

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/MybPlt3
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/MybPlt4
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Adarb1tm1Phs/Adarb1tm1Phs,Gria2tm1.1Phs/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/MybPlt4
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gbatm2Ggb/Gbatm1Nsb
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6

Allelic Composition: Mpltm2.1Wsa/Mpltm2.1Wsa,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Gbatm2Ggb/Gbatm1Nsb
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/MybPlt3
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/MybPlt4
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ergmld2/Erg+,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: B6.Cg-Mpltm1Wsa Ergmld2

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Plt8/Suz12Plt8
Genetic Background: B6.Cg-Mpltm1Wsa Suz12Plt8

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprdb-2J/Leprdb-2J
Genetic Background: involves: C57BL/6J * STOCK Tyrp1b Whrnwi

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gbatm2Ggb/Gbatm1Nsb
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6

Allelic Composition: Mpltm1Fjs/Mpltm1Fjs
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/MybPlt3
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/Myb+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/MybPlt4
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/Myb+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mplhlb219/Mpl+
Genetic Background: C57BL/6J-Mplhlb219/J

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/MybPlt3
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr/J

 MP:0002413 abnormal megakaryoblast morphology/development "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Mplhlb219/Mplhlb219
Genetic Background: C57BL/6J-Mplhlb219/J

Allelic Composition: Mpltm1Fjs/Mpltm1Fjs
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Ep300Plt6/Ep300Plt6,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ep300Plt6/Ep300+,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mpltm2.1Wsa/Mpltm2.1Wsa,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0002599 increased mean platelet volume "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ceacam9tm1Wzm/Ceacam9tm1Wzm
Genetic Background: either: (involves: 129/Sv * BALB/cJ) or (involves: BALB/cJ)

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mplhlb219/Mplhlb219
Genetic Background: C57BL/6J-Mplhlb219/J

Allelic Composition: Mplhlb219/Mpl+
Genetic Background: C57BL/6J-Mplhlb219/J

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mplhlb219/Mplhlb219
Genetic Background: C57BL/6J-Mplhlb219/J

Allelic Composition: Lynmld4/Lynmld4,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: B6.129S1-Mpltm1Wsa

Allelic Composition: Mplhlb219/Mpl+
Genetic Background: C57BL/6J-Mplhlb219/J

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Ceacam9tm1Wzm/Ceacam9tm1Wzm
Genetic Background: either: (involves: 129/Sv * BALB/cJ) or (involves: BALB/cJ)

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mplhlb219/Mplhlb219
Genetic Background: C57BL/6J-Mplhlb219/J

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Plt8/Suz12+
Genetic Background: B6.Cg-Mpltm1Wsa Suz12Plt8

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Ergmld2/Erg+,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: B6.Cg-Mpltm1Wsa Ergmld2

Allelic Composition: Fli1tm1Dkw/Fli1+,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

Allelic Composition: Lynmld4/Lynmld4,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: B6.129S1-Mpltm1Wsa

Allelic Composition: Mpltm2.2Wsa/Mpltm2.2Wsa
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0004720 abnormal platelet morphology "any structural anomaly of blood plasma cells derived from megakaryocytes, which function to promote blood clotting" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Ep300Plt6/Ep300+,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ep300Plt6/Ep300+,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Plt8/Suz12+
Genetic Background: B6.Cg-Mpltm1Wsa Suz12Plt8

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/MybPlt3
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/Myb+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/MybPlt4
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/Myb+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ep300Plt6/Ep300Plt6,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mplhlb219/Mpl+
Genetic Background: C57BL/6J-Mplhlb219/J

Allelic Composition: Mpltm2.1Wsa/Mpltm2.1Wsa,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Mplhlb219/Mplhlb219
Genetic Background: C57BL/6J-Mplhlb219/J

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mpltm2.1Wsa/Mpltm2.1Wsa,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0008253 absent megakaryocytes "absence of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
Show

Allelic Composition: Ceacam9tm1Wzm/Ceacam9tm1Wzm
Genetic Background: either: (involves: 129/Sv * BALB/cJ) or (involves: BALB/cJ)

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
Show

Allelic Composition: Ep300Plt6/Ep300Plt6,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ep300Plt6/Ep300+,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mpltm2.1Wsa/Mpltm2.1Wsa,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0008255 decreased megakaryocyte cell number "reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
Show

Allelic Composition: Mplhlb219/Mplhlb219
Genetic Background: C57BL/6J-Mplhlb219/J

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/MybPlt3
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/MybPlt4
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/MybPlt3
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt4/MybPlt4
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mplhlb219/Mplhlb219
Genetic Background: C57BL/6J-Mplhlb219/J

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mpltm2.1Wsa/Mpltm2.1Wsa,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0010209 abnormal circulating chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mplhlb219/Mplhlb219
Genetic Background: C57BL/6J-Mplhlb219/J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,MybPlt3/MybPlt3
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Plt8/Suz12Plt8
Genetic Background: B6.Cg-Mpltm1Wsa Suz12Plt8

 MP:0011902 increased hematopoietic stem cell proliferation "increase in the expansion rate of a hematopoietic stem cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Mpltm2.1Wsa/Mpltm2.1Wsa,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   


© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr