ENSMUSG00000006717


Mus musculus

Features
Gene ID: ENSMUSG00000006717
  
Biological name :Acot13
  
Synonyms : Acot13 / acyl-CoA thioesterase 13 / Q9CQR4
  
Possible biological names infered from orthology : Q9NPJ3
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A3.1
Gene start: 24817948
Gene end: 24831540
  
Corresponding Affymetrix probe sets: 10408331 (MoGene1.0st)   1417316_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006900
NCBI entrez gene - 66834     See in Manteia.
MGI - MGI:1914084
RefSeq - NM_025790
RefSeq Peptide - NP_080066
swissprot - Q4VA32
swissprot - Q9CQR4
Ensembl - ENSMUSG00000006717
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acot13ENSDARG00000061728Danio rerio
 ACOT13ENSGALG00000013632Gallus gallus
 ACOT13ENSG00000112304Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003736  Phenylacetic acid degradation-related domain
 IPR006683  Thioesterase domain
 IPR029069  HotDog domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0051289 protein homotetramerization IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0047617 acyl-CoA hydrolase activity ISS


Pathways (from Reactome)
Pathway description
Mitochondrial Fatty Acid Beta-Oxidation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Arhgap44Gt(RRZ340)Byg/Arhgap44+
Genetic Background: B6.129P2-Arhgap44Gt(RRZ340)Byg

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Megf8b2b1702.2Clo/Megf8b2b1702.2Clo
Genetic Background: C57BL/6J-Megf8b2b1702.2Clo

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Arhgap44Gt(RRZ340)Byg/Arhgap44+
Genetic Background: B6.129P2-Arhgap44Gt(RRZ340)Byg

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Megf8b2b1702.2Clo/Megf8b2b1702.2Clo
Genetic Background: C57BL/6J-Megf8b2b1702.2Clo

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Megf8b2b1702.2Clo/Megf8b2b1702.2Clo
Genetic Background: C57BL/6J-Megf8b2b1702.2Clo

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Megf8b2b1702.2Clo/Megf8b2b1702.2Clo
Genetic Background: C57BL/6J-Megf8b2b1702.2Clo

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Megf8b2b1702.2Clo/Megf8b2b1702.2Clo
Genetic Background: C57BL/6J-Megf8b2b1702.2Clo

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Megf8b2b1702.2Clo/Megf8b2b1702.2Clo
Genetic Background: C57BL/6J-Megf8b2b1702.2Clo

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Megf8b2b1702.2Clo/Megf8b2b1702.2Clo
Genetic Background: C57BL/6J-Megf8b2b1702.2Clo

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Megf8b2b1702.2Clo/Megf8b2b1702.2Clo
Genetic Background: C57BL/6J-Megf8b2b1702.2Clo

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Megf8b2b1702.2Clo/Megf8b2b1702.2Clo
Genetic Background: C57BL/6J-Megf8b2b1702.2Clo

 MP:0003458 decreased circulating ketone body level "less than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Megf8b2b1702.2Clo/Megf8b2b1702.2Clo
Genetic Background: C57BL/6J-Megf8b2b1702.2Clo

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Megf8b2b1702.2Clo/Megf8b2b1702.2Clo
Genetic Background: C57BL/6J-Megf8b2b1702.2Clo

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Megf8b2b1702.2Clo/Megf8b2b1702.2Clo
Genetic Background: C57BL/6J-Megf8b2b1702.2Clo

Allelic Composition: Acot13tm1Deco/Acot13tm1Deco
Genetic Background: Not Specified

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Acot13tm1Deco/Acot13tm1Deco
Genetic Background: Not Specified

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Arhgap44Gt(RRZ340)Byg/Arhgap44+
Genetic Background: B6.129P2-Arhgap44Gt(RRZ340)Byg

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Megf8b2b1702.2Clo/Megf8b2b1702.2Clo
Genetic Background: C57BL/6J-Megf8b2b1702.2Clo

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Megf8b2b1702.2Clo/Megf8b2b1702.2Clo
Genetic Background: C57BL/6J-Megf8b2b1702.2Clo

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Megf8b2b1702.2Clo/Megf8b2b1702.2Clo
Genetic Background: C57BL/6J-Megf8b2b1702.2Clo

 MP:0009125 decreased brown fat cell lipid droplet size "reduction in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Acot13tm1Deco/Acot13tm1Deco
Genetic Background: Not Specified

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Megf8b2b1702.2Clo/Megf8b2b1702.2Clo
Genetic Background: C57BL/6J-Megf8b2b1702.2Clo

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Megf8b2b1702.2Clo/Megf8b2b1702.2Clo
Genetic Background: C57BL/6J-Megf8b2b1702.2Clo

 MP:0010026 decreased liver cholesterol level "less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Megf8b2b1702.2Clo/Megf8b2b1702.2Clo
Genetic Background: C57BL/6J-Megf8b2b1702.2Clo

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Acot13tm1Deco/Acot13tm1Deco
Genetic Background: Not Specified

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Megf8b2b1702.2Clo/Megf8b2b1702.2Clo
Genetic Background: C57BL/6J-Megf8b2b1702.2Clo

 MP:0011016 increased core body temperature "increased degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Acot13tm1Deco/Acot13tm1Deco
Genetic Background: Not Specified

 MP:0011019 abnormal adaptive thermogenesis "anomaly in the regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [PMID:16836744]
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Allelic Composition: Acot13tm1Deco/Acot13tm1Deco
Genetic Background: Not Specified

 MP:0011020 abnormal circadian temperature homeostasis "any anomaly in the process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours" [GO:0060086]
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Allelic Composition: Acot13tm1Deco/Acot13tm1Deco
Genetic Background: Not Specified

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Acot13tm1Deco/Acot13tm1Deco
Genetic Background: Not Specified

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Acot13tm1Deco/Acot13tm1Deco
Genetic Background: Not Specified

 MP:0020234 decreased basal metabolism "decrease in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [GOC:NV]
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Allelic Composition: Megf8b2b1702.2Clo/Megf8b2b1702.2Clo
Genetic Background: C57BL/6J-Megf8b2b1702.2Clo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006717 Acot13 / Q9CQR4 / acyl-CoA thioesterase 13 / Q9NPJ3*  / complex






 

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