ENSMUSG00000007908


Mus musculus
activityHmgcll1ketonecytoplasmendoplasmicreticulummembranelyasepyruvatecarboxyltransferasealdolase-typetimbarrelhmg-coalyase-likebodybiosyntheticprocesscytosolperinuclearregioncatalytichydroxymethylglutaryl-coametalionbindingsynthesisbodies

Features
Gene ID: ENSMUSG00000007908
  
Biological name :Hmgcll1
  
Synonyms : 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic / Hmgcll1 / Q8JZS7
  
Possible biological names infered from orthology : 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1 / Q8TB92
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: D
Gene start: 76014855
Gene end: 76136350
  
Corresponding Affymetrix probe sets: 10587241 (MoGene1.0st)   1434913_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000008052
Ensembl peptide - ENSMUSP00000114045
Ensembl peptide - ENSMUSP00000138914
Ensembl peptide - ENSMUSP00000139094
NCBI entrez gene - 208982     See in Manteia.
MGI - MGI:2446108
RefSeq - XM_011242696
RefSeq - NM_173731
RefSeq - XM_006510947
RefSeq - XM_006510948
RefSeq - XM_006510949
RefSeq Peptide - NP_776092
swissprot - V9GXD2
swissprot - D3YVU9
swissprot - Q8JZS7
swissprot - V9GWZ9
Ensembl - ENSMUSG00000007908
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A8WG57ENSDARG00000088740Danio rerio
 HMGCLL1ENSGALG00000016294Gallus gallus
 Q8TB92ENSG00000146151Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hmgcl / P38060 / Hydroxymethylglutaryl-CoA lyase, mitochondrial / P35914* / 3-hydroxymethyl-3-methylglutaryl-CoA lyase*ENSMUSG0000002867261


Protein motifs (from Interpro)
Interpro ID Name
 IPR000891  Pyruvate carboxyltransferase
 IPR013785  Aldolase-type TIM barrel
 IPR030021  HMG-CoA lyase-like1


Gene Ontology (GO)
biosynthetic processcellular metabolic processsmall molecule metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processsmall molecule metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processsmall molecule metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processsmall molecule metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processsmall molecule metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processsmall molecule metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processsmall molecule metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processsmall molecule metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processsmall molecule metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processsmall molecule metabolic processorganic substance metabolic processbiosynthetic processbiosynthetic processcellular metabolic processcellular metabolic processsmall molecule metabolic processsmall molecule metabolic processorganic substance metabolic processorganic substance metabolic process
lyase activityion bindinglyase activityion bindinglyase activityion bindinglyase activityion bindinglyase activityion bindinglyase activityion bindinglyase activityion bindinglyase activityion bindinglyase activityion bindinglyase activityion bindinglyase activitylyase activityion bindingion binding
cellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellcellorganelleorganellemembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0046951 ketone body biosynthetic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004419 hydroxymethylglutaryl-CoA lyase activity IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0046872 metal ion binding ISS


Pathways (from Reactome)
Pathway description
Synthesis of Ketone Bodies


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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