ENSMUSG00000008193


Mus musculus

Features
Gene ID: ENSMUSG00000008193
  
Biological name :Spib
  
Synonyms : O35906 / Spib / Transcription factor Spi-B
  
Possible biological names infered from orthology : AC020909.1 / Q01892 / Spi-B transcription factor
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 44525993
Gene end: 44532071
  
Corresponding Affymetrix probe sets: 10562812 (MoGene1.0st)   1460407_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145968
Ensembl peptide - ENSMUSP00000035539
Ensembl peptide - ENSMUSP00000096084
NCBI entrez gene - 272382     See in Manteia.
MGI - MGI:892986
RefSeq - XM_006540939
RefSeq - XM_006540934
RefSeq - XM_006540935
RefSeq - XM_006540936
RefSeq - XM_006540938
RefSeq - NM_019866
RefSeq - XM_006540932
RefSeq - XM_006540933
RefSeq Peptide - NP_063919
swissprot - A0A0X1KG64
swissprot - A0A0U1RPG0
swissprot - O35906
Ensembl - ENSMUSG00000008193
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AC020909.1ENSG00000142539Homo sapiens
 SPIBENSG00000269404Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Spi1 / P17433 / spleen focus forming virus (SFFV) proviral integration oncogene / P17947* / Spi-1 proto-oncogene*ENSMUSG0000000211137
Spic / Q6P3D7 / Transcription factor Spi-C / Q8N5J4* / Spi-C transcription factor*ENSMUSG0000000435925


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0030225 macrophage differentiation IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IC
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding ISO
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Lepob/Lepob,Steap4tm1Dgen/Steap4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

 MP:0000696 abnormal Peyer s patches morphology "anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lepob/Lepob,Steap4tm1Dgen/Steap4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tbc1d20bs/Tbc1d20bs
Genetic Background: 129S;AKR-Tbc1d20bs/J

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spi1tm1Sing/Spi1+,Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tbc1d20bs/Tbc1d20bs
Genetic Background: 129S;AKR-Tbc1d20bs/J

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Spi1tm1Sing/Spi1tm1Sing,Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

Allelic Composition: Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lepob/Lepob,Steap4tm1Dgen/Steap4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Spi1tm1Sing/Spi1+,Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0005022 abnormal immature B cell "anomalous structure, development, or number of the cells of the B lymphocyte lineage that have undergone VDJ rearragnement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Spi1tm1Sing/Spi1+,Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Spi1tm1Sing/Spi1+,Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

Allelic Composition: Spi1tm1Sing/Spi1+,Spibtm1Mcs/Spib+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

Allelic Composition: Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
Show

Allelic Composition: Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Spi1tm1Sing/Spi1+,Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spi1tm1Sing/Spi1+,Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

Allelic Composition: Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Spi1tm1Sing/Spi1tm1Sing,Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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