ENSMUSG00000009090


Mus musculus

Features
Gene ID: ENSMUSG00000009090
  
Biological name :Ap1b1
  
Synonyms : Ap1b1 / Mus musculus adaptor protein complex AP-1, beta 1 subunit (Ap1b1), transcript variant 4, mRNA. / O35643
  
Possible biological names infered from orthology : adaptor related protein complex 1 beta 1 subunit / Q10567
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A1
Gene start: 4986824
Gene end: 5042791
  
Corresponding Affymetrix probe sets: 10373986 (MoGene1.0st)   1416279_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099134
Ensembl peptide - ENSMUSP00000105523
Ensembl peptide - ENSMUSP00000009234
NCBI entrez gene - 11764     See in Manteia.
MGI - MGI:1096368
RefSeq - NM_007454
RefSeq - XM_006514463
RefSeq - NM_001243043
RefSeq - NM_001243044
RefSeq - NM_001355659
RefSeq - NM_001355660
RefSeq - XM_006514461
RefSeq - XM_006514462
RefSeq Peptide - NP_001342589
RefSeq Peptide - NP_031480
RefSeq Peptide - NP_001229972
RefSeq Peptide - NP_001229973
RefSeq Peptide - NP_001342588
swissprot - O35643
swissprot - Q5SVG4
swissprot - Q5SVG5
Ensembl - ENSMUSG00000009090
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ap1b1ENSDARG00000020621Danio rerio
 AP1B1ENSGALG00000042213Gallus gallus
 AP1B1ENSG00000100280Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ap2b1 / Q9DBG3 / AP-2 complex subunit beta / P63010* / adaptor related protein complex 2 beta 1 subunit*ENSMUSG0000003515283
Ap4b1 / Q9WV76 / AP-4 complex subunit beta-1 / Q9Y6B7* / adaptor related protein complex 4 beta 1 subunit*ENSMUSG0000003295221
Gm43064 / AP4B1* / Q9Y6B7* / adaptor related protein complex 4 beta 1 subunit*ENSMUSG0000010505318


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR002553  Clathrin/coatomer adaptor, adaptin-like, N-terminal
 IPR008152  Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
 IPR009028  Coatomer/calthrin adaptor appendage, C-terminal subdomain
 IPR011989  Armadillo-like helical
 IPR013037  Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain
 IPR013041  Clathrin adaptor, appendage, Ig-like subdomain superfamily
 IPR015151  Beta-adaptin appendage, C-terminal subdomain
 IPR016024  Armadillo-type fold
 IPR016342  AP-1/2/4 complex subunit beta
 IPR026739  AP complex subunit beta
 IPR032682  Condensin complex subunit 1, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport TAS
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005802 trans-Golgi network TAS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030117 membrane coat IEA
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 cellular_componentGO:0030665 clathrin-coated vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030276 clathrin binding IEA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000690 absent spleen "missing organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Dnah5b2b1537Clo/Dnah5b2b1537Clo
Genetic Background: C57BL/6J-Dnah5b2b1537Clo

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Dnah5b2b1537Clo/Dnah5b2b1537Clo
Genetic Background: C57BL/6J-Dnah5b2b1537Clo

 MP:0003178 left pulmonary isomerism "bilaterally symmetric left lung pattern (or altered asymmetric patterning of the lung)" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93051]
Show

Allelic Composition: Dnah5b2b1537Clo/Dnah5b2b1537Clo
Genetic Background: C57BL/6J-Dnah5b2b1537Clo

 MP:0004133 heterotaxia "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Dnah5b2b1537Clo/Dnah5b2b1537Clo
Genetic Background: C57BL/6J-Dnah5b2b1537Clo

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnah5b2b1537Clo/Dnah5b2b1537Clo
Genetic Background: C57BL/6J-Dnah5b2b1537Clo

 MP:0006063 abnormal inferior vena cava morphology "structural malformation in the principal vein draining blood from the lower portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: Dnah5b2b1537Clo/Dnah5b2b1537Clo
Genetic Background: C57BL/6J-Dnah5b2b1537Clo

 MP:0011055 abnormal respiratory motile cilium physiology "any functional anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract; may include alterations in ciliary beating pattern or frequency" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnah5b2b1537Clo/Dnah5b2b1537Clo
Genetic Background: C57BL/6J-Dnah5b2b1537Clo

 MP:0011252 situs inversus totalis "the complete right to left reversal (transposition) of the thoracic and abdominal organs, including the heart (dextrocardia)" [MGI:csmith]
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Allelic Composition: Dnah5b2b1537Clo/Dnah5b2b1537Clo
Genetic Background: C57BL/6J-Dnah5b2b1537Clo

 MP:0011649 immotile respiratory cilia "failure of the multiple epithelial tiny, motile hair-like projections of the repiratory tract epithelium to beat with a characteristic whip-like pattern in order to promote transport of fluids and other cells across the epithelium of the respiratory tract" [MGI:csmith]
Show

Allelic Composition: Dnah5b2b1537Clo/Dnah5b2b1537Clo
Genetic Background: C57BL/6J-Dnah5b2b1537Clo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003033 Ap1m1 / P35585 / AP-1 complex subunit mu-1 / Q9BXS5* / adaptor related protein complex 1 mu 1 subunit*  / complex
 ENSMUSG00000003309 Ap1m2 / adaptor related protein complex 1 mu 2 subunit / Q9Y6Q5*  / complex
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / complex
 ENSMUSG00000031731 Ap1g1 / P22892 / AP-1 complex subunit gamma-1 / O43747* / adaptor related protein complex 1 gamma 1 subunit*  / complex
 ENSMUSG00000031367 Ap1s2 / Q9DB50 / AP-1 complex subunit sigma-2 / P56377* / adaptor related protein complex 1 sigma 2 subunit*  / complex
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / complex
 ENSMUSG00000024610 Cd74 / P04441 / CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) / P04233* / CD74 molecule*  / complex
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex
 ENSMUSG00000033335 Dnm2 / P39054 / Mus musculus dynamin 2 (Dnm2), transcript variant 5, mRNA. / P50570* / dynamin 2*  / complex / reaction
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex
 ENSMUSG00000004849 Ap1s1 / P61967 / AP-1 complex subunit sigma-1A / P61966* / adaptor related protein complex 1 sigma 1 subunit*  / complex
 ENSMUSG00000054702 Ap1s3 / Q7TN05 / AP-1 complex subunit sigma-3 / Q96PC3* / adaptor related protein complex 1 sigma 3 subunit*  / complex
 ENSMUSG00000019785 Clvs2 / Q8BG92 / Clavesin-2 / Q5SYC1*  / complex
 ENSMUSG00000041216 Clvs1 / Q9D4C9 / Clavesin-1 / Q8IUQ0*  / complex






 

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