ENSDARG00000020621


Danio rerio

Features
Gene ID: ENSDARG00000020621
  
Biological name :ap1b1
  
Synonyms : adaptor-related protein complex 1, beta 1 subunit / ap1b1
  
Possible biological names infered from orthology : Mus musculus adaptor protein complex AP-1, beta 1 subunit (Ap1b1), transcript variant 4, mRNA. / O35643 / Q10567
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 24756496
Gene end: 24812899
  
Corresponding Affymetrix probe sets: Dr.3412.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000122116
Ensembl peptide - ENSDARP00000155946
Ensembl peptide - ENSDARP00000148745
Ensembl peptide - ENSDARP00000116780
NCBI entrez gene - 562166     See in Manteia.
RefSeq - XM_005165167
RefSeq - XM_021476252
RefSeq - NM_001128530
RefSeq Peptide - NP_001122002
swissprot - A5PMT0
swissprot - A5PMS9
ZFIN ID - ZDB-GENE-061025-1
Ensembl - ENSDARG00000020621
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AP1B1ENSGALG00000042213Gallus gallus
 AP1B1ENSG00000100280Homo sapiens
 Ap1b1ENSMUSG00000009090Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ap2b1 / adaptor-related protein complex 2, beta 1 subunit / P63010* / Q9DBG3* / AP-2 complex subunit beta *ENSDARG0000003515282
ap4b1 / adaptor-related protein complex 4, beta 1 subunit / Q9WV76* / Q9Y6B7* / Gm43064* / AP-4 complex subunit beta-1 *ENSDARG0000001372622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR002553  Clathrin/coatomer adaptor, adaptin-like, N-terminal
 IPR008152  Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
 IPR009028  Coatomer/calthrin adaptor appendage, C-terminal subdomain
 IPR011989  Armadillo-like helical
 IPR013037  Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain
 IPR013041  Clathrin adaptor, appendage, Ig-like subdomain superfamily
 IPR015151  Beta-adaptin appendage, C-terminal subdomain
 IPR016024  Armadillo-type fold
 IPR016342  AP-1/2/4 complex subunit beta
 IPR026739  AP complex subunit beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006897 endocytosis IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0035315 hair cell differentiation IMP
 biological_processGO:0048839 inner ear development IMP
 biological_processGO:0048884 neuromast development IMP
 biological_processGO:0050974 detection of mechanical stimulus involved in sensory perception IMP
 biological_processGO:1903076 regulation of protein localization to plasma membrane IMP
 biological_processGO:2000649 regulation of sodium ion transmembrane transporter activity IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030117 membrane coat IEA
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 molecular_functionGO:0030276 clathrin binding IEA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000166 lateral crista lateral crista hair cell morphology , abnormal
Show

 ZFA:0000678 hair cell anterior macula hair cell anterior macula has extra parts of type hair cell anterior macula multivesicular body, abnormal
hair cell anterior macula vesicle increased diameter , abnormal
Show

 ZFA:0001094 whole organism whole organism unbalanced , abnormal
whole organism decreased behavioural activity , abnormal
whole organism circling , abnormal
Show

 ZFA:0009366 hair cell hair cell sodium:potassium-exchanging ATPase complex mislocalised , abnormal
hair cell stereocilium bundle decreased width , abnormal
Show

 ZFA:0009367 neuromast hair cell neuromast hair cell cellular quality , abnormal
neuromast hair cell functionality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000009087 cd74a / CD74 molecule, major histocompatibility complex, class II invariant chain a / CD74* / P04233* / P04441* / CD74 molecule* / CD74 antigen (invariant polypeptide of major histocompatib...  / complex
 ENSDARG00000096454 ap1m2 / adaptor-related protein complex 1, mu 2 subunit / Q9Y6Q5*  / complex
 ENSDARG00000027966 ap1s3b / adaptor-related protein complex 1, sigma 3 subunit, b / AP1S3* / Q96PC3* / Q7TN05* / AP-1 complex subunit sigma-3 * / adaptor related protein complex 1 sigma 3 subunit*  / complex
 ENSDARG00000045618 clta / clathrin, light chain A / P09496*  / complex
 ENSDARG00000053122 clvs2 / Q5SPP0 / clavesin 2 / CLVS1* / Q8IUQ0* / clavesin 1*  / complex
 ENSDARG00000056803 ap1s1 / adaptor-related protein complex 1, sigma 1 subunit / P61966* / P61967* / AP-1 complex subunit sigma-1A *  / complex
 ENSDARG00000110439 ap1s3a / adaptor-related protein complex 1, sigma 3 subunit, a / AP1S3* / Q96PC3* / adaptor related protein complex 1 sigma 3 subunit*  / complex
 ENSDARG00000096249 ap1m1 / adaptor-related protein complex 1, mu 1 subunit / Q9BXS5*  / complex
 ENSDARG00000090716 cltcb / clathrin, heavy chain b (Hc) / CLTC* / Q00610* / clathrin heavy chain*  / complex






 

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