ENSMUSG00000009772


Mus musculus
proteinkinaseNuak2bindingactivityincreasedcirculatingleveldomainserinesiteatpphosphorylationapoptoticprocessglucoseionneuralbodyretinalthreonine-proteinactivekinase-likesuperfamilyactincytoskeletonorganizationintracellularsignaltransductioncellular

Features
Gene ID: ENSMUSG00000009772
  
Biological name :Nuak2
  
Synonyms : Nuak2 / NUAK family SNF1-like kinase 2 / Q8BZN4
  
Possible biological names infered from orthology : NUAK family kinase 2 / Q9H093
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E4
Gene start: 132316126
Gene end: 132333488
  
Corresponding Affymetrix probe sets: 10349782 (MoGene1.0st)   1429049_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000072039
Ensembl peptide - ENSMUSP00000080769
NCBI entrez gene - 74137     See in Manteia.
MGI - MGI:1921387
RefSeq - NM_001195025
RefSeq - NM_028778
RefSeq Peptide - NP_001181954
RefSeq Peptide - NP_083054
swissprot - Q8BZN4
Ensembl - ENSMUSG00000009772
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nuak2ENSDARG00000063661Danio rerio
 NUAK2ENSGALG00000036616Gallus gallus
 NUAK2ENSG00000163545Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nuak1 / Q641K5 / NUAK family SNF1-like kinase 1 / O60285* / NUAK family kinase 1*ENSMUSG0000002003256
Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1*ENSMUSG0000005069727
Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*ENSMUSG0000002851826
Trib1 / Q8K4K4 / Tribbles homolog 1 / Q96RU8* / tribbles pseudokinase 1*ENSMUSG0000003250115
Trib2 / Q8K4K3 / Tribbles homolog 2 / Q92519* / tribbles pseudokinase 2*ENSMUSG0000002060114
Trib3 / Q8K4K2 / Tribbles homolog 3 / Q96RU7* / tribbles pseudokinase 3*ENSMUSG0000003271513
Stk40 / Q7TNL3 / Serine/threonine-protein kinase 40 / Q8N2I9* / serine/threonine kinase 40*ENSMUSG0000004260813


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
nitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathcellular component organizationactin filament-based processcell communicationcellular response to stimulusresponse to stressresponse to external stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathcellular component organizationactin filament-based processcell communicationcellular response to stimulusresponse to stressresponse to external stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathcellular component organizationactin filament-based processcell communicationcellular response to stimulusresponse to stressresponse to external stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathcellular component organizationactin filament-based processcell communicationcellular response to stimulusresponse to stressresponse to external stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathcellular component organizationactin filament-based processcell communicationcellular response to stimulusresponse to stressresponse to external stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathcellular component organizationactin filament-based processcell communicationcellular response to stimulusresponse to stressresponse to external stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathcellular component organizationactin filament-based processcell communicationcellular response to stimulusresponse to stressresponse to external stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathcellular component organizationactin filament-based processcell communicationcellular response to stimulusresponse to stressresponse to external stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathcellular component organizationactin filament-based processcell communicationcellular response to stimulusresponse to stressresponse to external stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathcellular component organizationactin filament-based processcell communicationcellular response to stimulusresponse to stressresponse to external stimulusnitrogen comnitrogen compound metabolic processcellular metcellular metabolic processprimary metaprimary metabolic processorganic subsorganic substance metabolic processcell deathcell deathcellular comcellular component organizationactin filameactin filament-based processcell communicell communicationcellular rescellular response to stimulusresponse to response to stressresponse to response to external stimulus
organic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcatalytic activity, acting on a proteintransferase activitycarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcatalytic activity, acting on a proteintransferase activitycarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcatalytic activity, acting on a proteintransferase activitycarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcatalytic activity, acting on a proteintransferase activitycarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcatalytic activity, acting on a proteintransferase activitycarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcatalytic activity, acting on a proteintransferase activitycarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcatalytic activity, acting on a proteintransferase activitycarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcatalytic activity, acting on a proteintransferase activitycarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcatalytic activity, acting on a proteintransferase activitycarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcatalytic activity, acting on a proteintransferase activitycarbohydrate derivative bindingdrug bindingorganic cyclic coorganic cyclic compound bindingheterocyclic compheterocyclic compound bindingsmall molecule bismall molecule bindingion bindingion bindingcatalytic activitcatalytic activity, acting on a proteintransferase activtransferase activitycarbohydrate dericarbohydrate derivative bindingdrug bindingdrug binding
cellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumen
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030036 actin cytoskeleton organization ISS
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0042149 cellular response to glucose starvation ISO
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding ISO
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
endocrine/exocrine gland phenotypedigestive/alimentary phenotypenervous system phenotypeembryogenesis phenotypegrowth/size phenotypehomeostasis/metabolism phenotypetumorigenesisvision/eye phenotypepigmentation phenotypecraniofacial phenotypemortality/agingendocrine/exocrine gland phenotypedigestive/alimentary phenotypenervous system phenotypeembryogenesis phenotypegrowth/size phenotypehomeostasis/metabolism phenotypetumorigenesisvision/eye phenotypepigmentation phenotypecraniofacial phenotypemortality/agingendocrine/exocrine gland phenotypedigestive/alimentary phenotypenervous system phenotypeembryogenesis phenotypegrowth/size phenotypehomeostasis/metabolism phenotypetumorigenesisvision/eye phenotypepigmentation phenotypecraniofacial phenotypemortality/agingendocrine/exocrine gland phenotypedigestive/alimentary phenotypenervous system phenotypeembryogenesis phenotypegrowth/size phenotypehomeostasis/metabolism phenotypetumorigenesisvision/eye phenotypepigmentation phenotypecraniofacial phenotypemortality/agingendocrine/exocrine gland phenotypedigestive/alimentary phenotypenervous system phenotypeembryogenesis phenotypegrowth/size phenotypehomeostasis/metabolism phenotypetumorigenesisvision/eye phenotypepigmentation phenotypecraniofacial phenotypemortality/agingendocrine/exocrine gland phenotypedigestive/alimentary phenotypenervous system phenotypeembryogenesis phenotypegrowth/size phenotypehomeostasis/metabolism phenotypetumorigenesisvision/eye phenotypepigmentation phenotypecraniofacial phenotypemortality/agingendocrine/exocrine gland phenotypedigestive/alimentary phenotypenervous system phenotypeembryogenesis phenotypegrowth/size phenotypehomeostasis/metabolism phenotypetumorigenesisvision/eye phenotypepigmentation phenotypecraniofacial phenotypemortality/agingendocrine/exocrine gland phenotypedigestive/alimentary phenotypenervous system phenotypeembryogenesis phenotypegrowth/size phenotypehomeostasis/metabolism phenotypetumorigenesisvision/eye phenotypepigmentation phenotypecraniofacial phenotypemortality/agingendocrine/exocrine gland phenotypedigestive/alimentary phenotypenervous system phenotypeembryogenesis phenotypegrowth/size phenotypehomeostasis/metabolism phenotypetumorigenesisvision/eye phenotypepigmentation phenotypecraniofacial phenotypemortality/agingendocrine/exocrine gland phenotypedigestive/alimentary phenotypenervous system phenotypeembryogenesis phenotypegrowth/size phenotypehomeostasis/metabolism phenotypetumorigenesisvision/eye phenotypepigmentation phenotypecraniofacial phenotypemortality/agingendocrine/exendocrine/exocrine gland phenotypedigestive/aldigestive/alimentary phenotypenervous systnervous system phenotypeembryogenesiembryogenesis phenotypegrowth/size growth/size phenotypehomeostasis/homeostasis/metabolism phenotypetumorigenesitumorigenesisvision/eye pvision/eye phenotypepigmentationpigmentation phenotypecraniofacialcraniofacial phenotypemortality/agmortality/aging
IDPhenotypeDefinition Genetic BG
 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cebpatm1.1(Cebpb)Ylee/Cebpatm1.1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Nuak2tm1Esu/Nuak2+
Genetic Background: B6.129S4-Nuak2tm1Esu

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Cebpatm1.1(Cebpb)Ylee/Cebpatm1.1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Nuak2tm1Sia/Nuak2tm1Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Nuak1tm1Sia/Nuak1tm1Sia,Nuak2tm1Sia/Nuak2tm1Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
Show

Allelic Composition: Nuak1tm1Sia/Nuak1tm1Sia,Nuak2tm1Sia/Nuak2tm1Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Nuak2tm1Esu/Nuak2+
Genetic Background: B6.129S4-Nuak2tm1Esu

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Nuak2tm1Esu/Nuak2+
Genetic Background: B6.129S4-Nuak2tm1Esu

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nuak2tm1Esu/Nuak2+
Genetic Background: B6.129S4-Nuak2tm1Esu

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nuak2tm1Esu/Nuak2+
Genetic Background: B6.129S4-Nuak2tm1Esu

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Nuak1tm1Sia/Nuak1tm1Sia,Nuak2tm1Sia/Nuak2tm1Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0003385 abnormal body wall "malformation in the external portion of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nuak1tm1Sia/Nuak1tm1Sia,Nuak2tm1Sia/Nuak2tm1Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nuak1tm1Sia/Nuak1tm1Sia,Nuak2tm1Sia/Nuak2tm1Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nuak1tm1Sia/Nuak1tm1Sia,Nuak2tm1Sia/Nuak2tm1Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Nuak2tm1Esu/Nuak2+
Genetic Background: B6.129S4-Nuak2tm1Esu

 MP:0005657 abnormal neural plate morphology "malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]
Show

Allelic Composition: Nuak1tm1Sia/Nuak1tm1Sia,Nuak2tm1Sia/Nuak2tm1Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
Show

Allelic Composition: Nuak1tm1Sia/Nuak1tm1Sia,Nuak2tm1Sia/Nuak2tm1Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0008797 facial cleft "a cleft resulting from incomplete merging or fusion of any of the embryonic facial processes that normally unite to form the face" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nuak1tm1Sia/Nuak1tm1Sia,Nuak2tm1Sia/Nuak2tm1Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cebpatm1.1(Cebpb)Ylee/Cebpatm1.1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0012535 abnormal optic fissure closure "failure to initiate and/or complete closure of the transient gap in the ventral margin of the developing optic cup; fusion of the optic fissure begins with apposition of the inferior lips of the ventral-most optic cup and continues anteriorly toward its rim and posteriorly along the optic stalk; failure or late closure of the optic fissure prevents the establishment of normal fetal intraocular pressure and can result in microphthalmia associataed with colobomas" [MGI:anna]
Show

Allelic Composition: Nuak1tm1Sia/Nuak1tm1Sia,Nuak2tm1Sia/Nuak2tm1Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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