Manteia

ENSMUSG00000032715

Mus musculus

Features

Gene ID:	ENSMUSG00000032715

Biological name :	Trib3

Synonyms :	Q8K4K2 / Trib3 / Tribbles homolog 3

Possible biological names infered from orthology :	Q96RU7 / tribbles pseudokinase 3

Species:	Mus musculus

Chr. number:	2
Strand:	-1
Band:	G3
Gene start:	152337422
Gene end:	152344032

Corresponding Affymetrix probe sets:	10488608 (MoGene1.0st) 1426065_a_at (Mouse Genome 430 2.0 Array) 1456225_x_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000041747 NCBI entrez gene - 228775 See in Manteia. MGI - MGI:1345675 RefSeq - NM_175093 RefSeq Peptide - NP_780302 swissprot - Q8K4K2 Ensembl - ENSMUSG00000032715

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
trib3	ENSDARG00000016200	Danio rerio
TRIB3	ENSG00000101255	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Trib2 / Q8K4K3 / Tribbles homolog 2 / Q92519* / tribbles pseudokinase 2*	ENSMUSG00000020601	47
Trib1 / Q8K4K4 / Tribbles homolog 1 / Q96RU8* / tribbles pseudokinase 1*	ENSMUSG00000032501	46
Nuak1 / Q641K5 / NUAK family SNF1-like kinase 1 / O60285* / NUAK family kinase 1*	ENSMUSG00000020032	26
Stk40 / Q7TNL3 / Serine/threonine-protein kinase 40 / Q8N2I9* / serine/threonine kinase 40*	ENSMUSG00000042608	25
Nuak2 / Q8BZN4 / NUAK family SNF1-like kinase 2 / Q9H093* / NUAK family kinase 2*	ENSMUSG00000009772	24
Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*	ENSMUSG00000028518	21
Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1*	ENSMUSG00000050697	21

Protein motifs (from Interpro)

Interpro ID	Name
IPR000719	Protein kinase domain
IPR011009	Protein kinase-like domain superfamily
IPR024104	Pseudokinase tribbles family/serine-threonine-protein kinase 40
IPR024106	Pseudokinase tribbles, TRB3

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006468	protein phosphorylation	IEA
biological_process	GO:0006469	negative regulation of protein kinase activity	ISO
biological_process	GO:0006915	apoptotic process	IEA
biological_process	GO:0010827	regulation of glucose transmembrane transport	IDA
biological_process	GO:0032092	positive regulation of protein binding	IDA
biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	TAS
biological_process	GO:0032869	cellular response to insulin stimulus	IDA
biological_process	GO:0034976	response to endoplasmic reticulum stress	ISO
biological_process	GO:0043405	regulation of MAP kinase activity	IBA
biological_process	GO:0045599	negative regulation of fat cell differentiation	IMP
biological_process	GO:0045717	negative regulation of fatty acid biosynthetic process	IMP
biological_process	GO:0045732	positive regulation of protein catabolic process	IC
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	ISS
biological_process	GO:0051443	positive regulation of ubiquitin-protein transferase activity	IDA
biological_process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISS
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005730	nucleolus	IEA
cellular_component	GO:0031965	nuclear membrane	IEA
molecular_function	GO:0003714	transcription corepressor activity	IDA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004860	protein kinase inhibitor activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0019899	enzyme binding	IPI
molecular_function	GO:0019901	protein kinase binding	ISS
molecular_function	GO:0031434	mitogen-activated protein kinase kinase binding	IBA
molecular_function	GO:0031625	ubiquitin protein ligase binding	IPI
molecular_function	GO:0055106	ubiquitin-protein transferase regulator activity	IDA

Pathways (from Reactome)

Pathway description

PIP3 activates AKT signaling

Activation of AKT2

Negative regulation of the PI3K/AKT network

CD28 dependent PI3K/Akt signaling

VEGFR2 mediated vascular permeability

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002423	abnormal mast cell physiology	"anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cacna1s^tm1.1Cann/Cacna1s^tm1.1Cann Genetic Background: involves: 129
MP:0008765	decreased mast cell degranulation	"reduction in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cacna1s^tm1.1Cann/Cacna1s^tm1.1Cann Genetic Background: involves: 129
MP:0014118	decreased pancreatic beta cell apoptosis	"decrease in the number of pancreatic beta cells undergoing programmed cell death" [MGI:Anna]	Show Allelic Composition: Tpcn1^{Gt(OST359423)Lex}/Tpcn1^{Gt(OST359423)Lex} Genetic Background: B6;129S5-Tpcn1^{Gt(OST359423)Lex}/Orl

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000001729	Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*	/ complex / reaction
ENSMUSG00000004056	Akt2 / Q60823 / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA. / P31751* / AKT serine/threonine kinase 2*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr