ENSMUSG00000011305


Mus musculus

Features
Gene ID: ENSMUSG00000011305
  
Biological name :Plin5
  
Synonyms : Perilipin-5 / Plin5 / Q8BVZ1
  
Possible biological names infered from orthology : Q00G26
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: D
Gene start: 56111601
Gene end: 56117596
  
Corresponding Affymetrix probe sets: 10451943 (MoGene1.0st)   1424937_at (Mouse Genome 430 2.0 Array)   1441915_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019808
Ensembl peptide - ENSMUSP00000108695
NCBI entrez gene - 66968     See in Manteia.
MGI - MGI:1914218
RefSeq - XM_017317614
RefSeq - NM_001077348
RefSeq - NM_025874
RefSeq - XM_006524805
RefSeq Peptide - NP_001070816
RefSeq Peptide - NP_080150
swissprot - Q8BVZ1
Ensembl - ENSMUSG00000011305
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plin6ENSDARG00000076844Danio rerio
 PLIN5ENSG00000214456Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plin3 / Q9DBG5 / Perilipin-3 / O60664*ENSMUSG0000002419734
Plin2 / P43883 / Perilipin-2 / Q99541*ENSMUSG0000002849429
Plin1 / Q8CGN5 / Perilipin-1 / O60240*ENSMUSG0000003054621
Plin4 / O88492 / Perilipin-4 / Q96Q06*ENSMUSG0000000283117


Protein motifs (from Interpro)
Interpro ID Name
 IPR004279  Perilipin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0010867 positive regulation of triglyceride biosynthetic process IMP
 biological_processGO:0010884 positive regulation of lipid storage ISS
 biological_processGO:0010890 positive regulation of sequestering of triglyceride IDA
 biological_processGO:0010897 negative regulation of triglyceride catabolic process IDA
 biological_processGO:0019915 lipid storage IDA
 biological_processGO:0031999 negative regulation of fatty acid beta-oxidation IMP
 biological_processGO:0032000 positive regulation of fatty acid beta-oxidation IDA
 biological_processGO:0034389 lipid particle organization IMP
 biological_processGO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway IDA
 biological_processGO:0050995 negative regulation of lipid catabolic process IDA
 biological_processGO:0051646 mitochondrion localization IMP
 biological_processGO:0060192 negative regulation of lipase activity IMP
 biological_processGO:0060193 positive regulation of lipase activity ISS
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISS
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035473 lipase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Fhod3tm1Hsum/Fhod3+,Tg(Myh6-Fhod3*I1127A)#Hsum/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fhod3tm1Hsum/Fhod3+,Tg(Myh6-Fhod3*I1127A)#Hsum/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Fhod3tm1Hsum/Fhod3+,Tg(Myh6-Fhod3*I1127A)#Hsum/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fhod3tm1Hsum/Fhod3+,Tg(Myh6-Fhod3*I1127A)#Hsum/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fhod3tm1Hsum/Fhod3+,Tg(Myh6-Fhod3*I1127A)#Hsum/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fhod3tm1Hsum/Fhod3+,Tg(Myh6-Fhod3*I1127A)#Hsum/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fhod3tm1Hsum/Fhod3+,Tg(Myh6-Fhod3*I1127A)#Hsum/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Musktm1.2Ics/Musktm1.2Ics
Genetic Background: involves: BALB/cN * C57BL/6NTac

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fhod3tm1Hsum/Fhod3+,Tg(Myh6-Fhod3*I1127A)#Hsum/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fhod3tm1Hsum/Fhod3+,Tg(Myh6-Fhod3*I1127A)#Hsum/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0008034 enhanced lipolysis "increase in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fhod3tm1Hsum/Fhod3+,Tg(Myh6-Fhod3*I1127A)#Hsum/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fhod3tm1Hsum/Fhod3+,Tg(Myh6-Fhod3*I1127A)#Hsum/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0009823 abnormal sphingomyelin level "deviation in the expected amount of any of a group of phospholipids that are found especially in, but not restricted to, nerve tissue and yield sphingosine, choline, a fatty acid, and phosphoric acid upon hydrolysis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0010359 increased liver free fatty acids level "elevated liver concentrations of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Fhod3tm1Hsum/Fhod3+,Tg(Myh6-Fhod3*I1127A)#Hsum/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0010360 decreased liver free fatty acids level "reduced liver concentration of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Fhod3tm1Hsum/Fhod3+,Tg(Myh6-Fhod3*I1127A)#Hsum/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0010399 decreased skeletal muscle glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0012232 abnormal ceramide level 
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0013243 abnormal carbohydrate metabolism "any anomaly in the chemical reactions and pathways involving a carbohydrate, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]
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Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0014171 increased fatty acid oxidation "increased rate or incidence of the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen" [GO:0019395]
Show

Allelic Composition: Fhod3tm1Hsum/Fhod3+,Tg(Myh6-Fhod3*I1127A)#Hsum/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0014172 decreased fatty acid oxidation 
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0030017 decreased adipocyte glucose uptake "reduced ability of adipocytes to take in glucose" [MGI:anna]
Show

Allelic Composition: Plin5tm1e(KOMP)Wtsi/Plin5tm1e(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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