ENSMUSG00000012519


Mus musculus

Features
Gene ID: ENSMUSG00000012519
  
Biological name :Mlkl
  
Synonyms : Mixed lineage kinase domain-like protein / Mlkl / Q9D2Y4
  
Possible biological names infered from orthology : mixed lineage kinase domain like pseudokinase / Q8NB16
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E1
Gene start: 111311797
Gene end: 111338177
  
Corresponding Affymetrix probe sets: 10581813 (MoGene1.0st)   1429570_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000055521
Ensembl peptide - ENSMUSP00000113718
Ensembl peptide - ENSMUSP00000114701
NCBI entrez gene - 74568     See in Manteia.
MGI - MGI:1921818
RefSeq - XM_006531443
RefSeq - NM_001310613
RefSeq - NM_029005
RefSeq - XM_006531442
RefSeq Peptide - NP_083281
RefSeq Peptide - NP_001297542
swissprot - Q9D2Y4
swissprot - D3YV42
Ensembl - ENSMUSG00000012519
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MLKLENSGALG00000002766Gallus gallus
 MLKLENSG00000168404Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0012501 programmed cell death IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0070207 protein homotrimerization ISO
 biological_processGO:0070266 necroptotic process IMP
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0044877 protein-containing complex binding IEA


Pathways (from Reactome)
Pathway description
TRP channels
RIPK1-mediated regulated necrosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak3m3Btlr/Jak3m3Btlr
Genetic Background: C57BL/6J-Jak3m3Btlr

Allelic Composition: Mlklm1Btlr/Mlkl+
Genetic Background: C57BL/6J-Mlklm1Btlr

Allelic Composition: Mlklm2Btlr/Mlklm2Btlr
Genetic Background: C57BL/6J-Mlklm2Btlr

Allelic Composition: Mlklm2Btlr/Mlkl+
Genetic Background: C57BL/6J-Mlklm2Btlr

Allelic Composition: Mlklm3Btlr/Mlklm3Btlr
Genetic Background: C57BL/6J-Mlklm3Btlr

Allelic Composition: Mlklm3Btlr/Mlkl+
Genetic Background: C57BL/6J-Mlklm3Btlr

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbx3tm3.2Moon/Tbx3tm3.2Moon
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * SJL

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tbx3tm3.2Moon/Tbx3tm3.2Moon
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * SJL

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx3tm3.2Moon/Tbx3tm3.2Moon
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * SJL

Allelic Composition: Mlkltm1.2Wsa/Mlkltm1.2Wsa
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0012555 decreased cell death "decreased occurrence of the cessation of function at the cellular level" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Jak3m3Btlr/Jak3m3Btlr
Genetic Background: C57BL/6J-Jak3m3Btlr

Allelic Composition: Mlklm1Btlr/Mlkl+
Genetic Background: C57BL/6J-Mlklm1Btlr

Allelic Composition: Mlklm2Btlr/Mlklm2Btlr
Genetic Background: C57BL/6J-Mlklm2Btlr

Allelic Composition: Mlklm2Btlr/Mlkl+
Genetic Background: C57BL/6J-Mlklm2Btlr

Allelic Composition: Mlklm3Btlr/Mlklm3Btlr
Genetic Background: C57BL/6J-Mlklm3Btlr

Allelic Composition: Mlklm3Btlr/Mlkl+
Genetic Background: C57BL/6J-Mlklm3Btlr

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Ripk3tm2Vmd/Ripk3tm2Vmd,Zbp1tm1Aki/Zbp1tm1Aki
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022221 Ripk3 / Q9QZL0 / receptor-interacting serine-threonine kinase 3 / Q9Y572*  / complex / reaction
 ENSMUSG00000021408 Ripk1 / Q60855 / Receptor-interacting serine/threonine-protein kinase 1 / Q13546* / receptor interacting serine/threonine kinase 1*  / complex / reaction
 ENSMUSG00000012519 Mlkl / Q9D2Y4 / Mixed lineage kinase domain-like protein / Q8NB16* / mixed lineage kinase domain like pseudokinase*  / - / complex / reaction






 

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