ENSMUSG00000014030


Mus musculus

Features
Gene ID: ENSMUSG00000014030
  
Biological name :Pax5
  
Synonyms : Paired box protein Pax-5 / Pax5 / Q02650
  
Possible biological names infered from orthology : paired box 5 / Q02548
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: B1
Gene start: 44524757
Gene end: 44710487
  
Corresponding Affymetrix probe sets: 10512669 (MoGene1.0st)   1421765_at (Mouse Genome 430 2.0 Array)   1454401_at (Mouse Genome 430 2.0 Array)   1458978_at (Mouse Genome 430 2.0 Array)   1459916_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134119
Ensembl peptide - ENSMUSP00000141303
Ensembl peptide - ENSMUSP00000141186
Ensembl peptide - ENSMUSP00000139296
Ensembl peptide - ENSMUSP00000134712
Ensembl peptide - ENSMUSP00000134391
Ensembl peptide - ENSMUSP00000134370
Ensembl peptide - ENSMUSP00000014174
Ensembl peptide - ENSMUSP00000099996
Ensembl peptide - ENSMUSP00000103455
Ensembl peptide - ENSMUSP00000103457
Ensembl peptide - ENSMUSP00000103458
Ensembl peptide - ENSMUSP00000128880
Ensembl peptide - ENSMUSP00000133540
Ensembl peptide - ENSMUSP00000133671
Ensembl peptide - ENSMUSP00000133978
NCBI entrez gene - 18507     See in Manteia.
MGI - MGI:97489
RefSeq - NM_008782
RefSeq - XM_006537673
RefSeq - XM_006537674
RefSeq Peptide - NP_032808
swissprot - A0A087WST9
swissprot - G3UW65
swissprot - G3UX39
swissprot - G3UXF6
swissprot - G3UY80
swissprot - A2AKM8
swissprot - G3UZ71
swissprot - G3UZ86
swissprot - G3V008
swissprot - Q02650
swissprot - V9GXS5
swissprot - G3UYK4
swissprot - A2AKM7
swissprot - A2AKM6
swissprot - A2AKM5
swissprot - A0A0A6YVX2
Ensembl - ENSMUSG00000014030
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pax5ENSDARG00000037383Danio rerio
 PAX5ENSGALG00000016431Gallus gallus
 PAX5ENSG00000196092Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pax2 / paired box 2 / Q02962*ENSMUSG0000000423171
Pax8 / Q00288 / Paired box protein Pax-8 / Q06710* / paired box 8*ENSMUSG0000002697660
Pax7 / P47239 / Paired box protein Pax-7 / P23759* / paired box 7*ENSMUSG0000002873640
Pax3 / P24610 / paired box 3 / P23760*ENSMUSG0000000487238
Pax6 / P63015 / Paired box protein Pax-6 / P26367* / paired box 6*ENSMUSG0000002716837
Pax1 / P09084 / Paired box protein Pax-1 / P15863* / paired box 1*ENSMUSG0000003703436
Pax9 / P47242 / Paired box protein Pax-9 / P55771* / paired box 9*ENSMUSG0000000149731
Pax4 / P32115 / paired box 4 / O43316*ENSMUSG0000002970627


Protein motifs (from Interpro)
Interpro ID Name
 IPR001523  Paired domain
 IPR009057  Homeobox-like domain superfamily
 IPR022130  Paired-box protein 2 C-terminal
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007568 aging IMP
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0021670 lateral ventricle development IMP
 biological_processGO:0021987 cerebral cortex development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030534 adult behavior IMP
 biological_processGO:0035914 skeletal muscle cell differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated TAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0051573 negative regulation of histone H3-K9 methylation IMP
 biological_processGO:0071542 dopaminergic neuron differentiation TAS
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex TAS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
RUNX1 regulates transcription of genes involved in BCR signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nlrp3M9Btlr/Nlrp3+
Genetic Background: C57BL/6J-Nlrp3M9Btlr

 MP:0000440 domed skull 
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Allelic Composition: Pax5tm3Mbu/Pax5tm3Mbu,Tg(Gad1-cre,-lacZ)1Mini/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Pax5tm3Mbu/Pax5+,Tg(Gad1-cre,-lacZ)1Mini/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Pax5tm3Mbu/Pax5tm3Mbu,Tg(Gad1-cre,-lacZ)1Mini/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
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Allelic Composition: Pax5tm3Mbu/Pax5tm3Mbu,Tg(Gad1-cre,-lacZ)1Mini/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Pax5tm3Mbu/Pax5+,Tg(Gad1-cre,-lacZ)1Mini/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Pitx2tm3.1Jfm/Pitx2tm3.1Jfm
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Pax5tm1Mbu/Pax5tm1Mbu
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
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Allelic Composition: Timp2tm1Pds/Timp2tm1Pds
Genetic Background: B6.129S4-Timp2tm1Pds

 MP:0000864 abnormal vermis "malformation in the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: Pax5tm1Mbu/Pax5tm1Mbu
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Timp2tm1Pds/Timp2tm1Pds
Genetic Background: B6.129S4-Timp2tm1Pds

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Timp2tm1Pds/Timp2tm1Pds
Genetic Background: B6.129S4-Timp2tm1Pds

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Zbtb7btm4.1Itan/Zbtb7btm4.1Itan
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pax5tm3Mbu/Pax5+,Tg(Gad1-cre,-lacZ)1Mini/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Pax5tm3Mbu/Pax5tm3Mbu,Tg(Gad1-cre,-lacZ)1Mini/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Pax5tm3Mbu/Pax5+,Tg(Gad1-cre,-lacZ)1Mini/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Timp2tm1Pds/Timp2tm1Pds
Genetic Background: B6.129S4-Timp2tm1Pds

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gata3tm1.2Mbu/Gata3tm1.2Mbu
Genetic Background: C3.129P2-Gata3tm1.2Mbu

Allelic Composition: Pax5tm3.1Mbu/Pax5tm3.1Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pax5m2Btlr/Pax5+
Genetic Background: C57BL/6J-Pax5m2Btlr

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Timp2tm1Pds/Timp2tm1Pds
Genetic Background: B6.129S4-Timp2tm1Pds

Allelic Composition: Pax5tm1Mbu/Pax5tm1Mbu
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Pax5tm3.1Mbu/Pax5tm3.1Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pax5tm1Mbu/Pax5tm1Mbu
Genetic Background: either: 129 or (involves: 129S2/SvPas * C57BL/6J)

Allelic Composition: Pax5tm3Mbu/Pax5+,Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Pax5tm1Mbu/Pax5tm3Mbu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Pax5m1Btlr/Pax5m1Btlr
Genetic Background: C57BL/6J-Pax5m1Btlr

Allelic Composition: Pax5m3Btlr/Pax5m3Btlr
Genetic Background: C57BL/6J-Pax5m3Btlr

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax5m1Btlr/Pax5m1Btlr
Genetic Background: C57BL/6J-Pax5m1Btlr

Allelic Composition: Pax5m3Btlr/Pax5m3Btlr
Genetic Background: C57BL/6J-Pax5m3Btlr

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nlrp3M9Btlr/Nlrp3+
Genetic Background: C57BL/6J-Nlrp3M9Btlr

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Pax5tm3Mbu/Pax5tm3Mbu,Tg(Gad1-cre,-lacZ)1Mini/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Pax5tm3Mbu/Pax5+,Tg(Gad1-cre,-lacZ)1Mini/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Timp2tm1Pds/Timp2tm1Pds
Genetic Background: B6.129S4-Timp2tm1Pds

Allelic Composition: Pax5tm3Mbu/Pax5tm3Mbu,Tg(Gad1-cre,-lacZ)1Mini/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Pax5tm3Mbu/Pax5+,Tg(Gad1-cre,-lacZ)1Mini/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Timp2tm1Pds/Timp2tm1Pds
Genetic Background: B6.129S4-Timp2tm1Pds

Allelic Composition: Ightm1(PAX5)Mbu/Igh+,Pax5tm1Mbu/Pax5tm1Mbu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Pax5tm1Mbu/Pax5tm3Mbu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata3tm1.2Mbu/Gata3tm1.2Mbu
Genetic Background: C3.129P2-Gata3tm1.2Mbu

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Timp2tm1Pds/Timp2tm1Pds
Genetic Background: B6.129S4-Timp2tm1Pds

Allelic Composition: Pax5tm1Mbu/Pax5tm1Mbu
Genetic Background: either: 129 or (involves: 129S2/SvPas * C57BL/6J)

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata3tm1.2Mbu/Gata3tm1.2Mbu
Genetic Background: C3.129P2-Gata3tm1.2Mbu

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Timp2tm1Pds/Timp2tm1Pds
Genetic Background: B6.129S4-Timp2tm1Pds

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Pax5tm1Mbu/Pax5tm3Mbu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pax5tm1Mbu/Pax5tm1Mbu
Genetic Background: involves: 129S2/SvPas

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Pax5tm1Mbu/Pax5tm1Mbu
Genetic Background: involves: 129S2/SvPas

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Pax5tm1Mbu/Pax5tm3Mbu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0004977 increased B-1 B cell number "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltbrm2Btlr/Ltbrm2Btlr
Genetic Background: C57BL/6J-Ltbrm2Btlr

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax5tm1Mbu/Pax5tm1Mbu
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Pax5m3Btlr/Pax5m3Btlr
Genetic Background: C57BL/6J-Pax5m3Btlr

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax5tm1Mbu/Pax5tm1Mbu
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Pax5m1Btlr/Pax5m1Btlr
Genetic Background: C57BL/6J-Pax5m1Btlr

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax5tm1Mbu/Pax5tm1Mbu
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ightm1(PAX5)Mbu/Igh+,Pax5tm1Mbu/Pax5tm1Mbu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA

Allelic Composition: Pax5m1Btlr/Pax5m1Btlr
Genetic Background: C57BL/6J-Pax5m1Btlr

Allelic Composition: Pax5m1Anu/Pax5m1Anu
Genetic Background: C57BL/6JAnu-Pax5m1Anu

Allelic Composition: Pax5m3Btlr/Pax5m3Btlr
Genetic Background: C57BL/6J-Pax5m3Btlr

Allelic Composition: Pax5m3Btlr/Pax5+
Genetic Background: C57BL/6J-Pax5m3Btlr

 MP:0005020 abnormal late pro-B cell "anomalous structure, developoment, or number of the cells in the B lymphocyte lineage that undergo V-DJ rearrangement of the immunoglobulin heavy chain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pax5tm1Mbu/Pax5tm1Mbu
Genetic Background: either: 129 or (involves: 129S2/SvPas * C57BL/6J)

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Pax5m1Btlr/Pax5m1Btlr
Genetic Background: C57BL/6J-Pax5m1Btlr

 MP:0005432 abnormal pro-B cell "anomalous structure, development, or number of cells in the developing B cell lineage that have displayed B cell surface markers, but have not yet completed heavy chain gene rearrangement" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax5tm3Mbu/Pax5+,Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005434 deficiency of late pro-B cells "lack of the cells in the B lymphocyte lineage that undergo V-DJ rearrangement of the immunoglobulin heavy chain" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pax5tm1Mbu/Pax5tm1Mbu
Genetic Background: either: 129 or (involves: 129S2/SvPas * C57BL/6J)

 MP:0006097 abnormal cerebellar lobule formation "anomaly in the formation of the lobes of the cerebellum" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]
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Allelic Composition: Pitx2tm3.1Jfm/Pitx2tm3.1Jfm
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
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Allelic Composition: Pax5tm1Mbu/Pax5tm1Mbu
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax5m1Btlr/Pax5m1Btlr
Genetic Background: C57BL/6J-Pax5m1Btlr

 MP:0008170 decreased B-1b cell number "reduced number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
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Allelic Composition: Ltbrm2Btlr/Ltbrm2Btlr
Genetic Background: C57BL/6J-Ltbrm2Btlr

Allelic Composition: Pax5m2Btlr/Pax5+
Genetic Background: C57BL/6J-Pax5m2Btlr

 MP:0008205 absent B-2 cells "absence of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Pax5tm1Mbu/Pax5tm1Mbu
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Pax5tm1Mbu/Pax5tm3Mbu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Pax5tm1Mbu/Pax5tm1Mbu
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Pax5tm1Mbu/Pax5tm3Mbu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008212 absent mature B cells "absence of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax5tm1Mbu/Pax5tm1Mbu
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax5tm1Mbu/Pax5tm1Mbu
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Pax5tm1Mbu/Pax5tm3Mbu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Pax5tm3Mbu/Pax5+,Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Pax5tm1Mbu/Pax5tm3Mbu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Pax5m1Btlr/Pax5m1Btlr
Genetic Background: C57BL/6J-Pax5m1Btlr

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax5m1Btlr/Pax5m1Btlr
Genetic Background: C57BL/6J-Pax5m1Btlr

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax5m1Btlr/Pax5m1Btlr
Genetic Background: C57BL/6J-Pax5m1Btlr

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Pax5tm1Mbu/Pax5tm3Mbu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008760 abnormal immunoglobulin heavy chain V(D)J recombination "any anomaly in the process by which V, D, and J gene segments of the immunoglobulin heavy chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax5tm1Mbu/Pax5tm1Mbu
Genetic Background: involves: 129S2/SvPas

 MP:0009038 decreased inferior colliculus size "decreased size of the paired inferior eminence of the mesencephalic tectum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax5tm1Mbu/Pax5tm1Mbu
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010168 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a greater number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: Pax5m3Btlr/Pax5m3Btlr
Genetic Background: C57BL/6J-Pax5m3Btlr

 MP:0010838 increased CD8-positive, alpha-beta memory T cell number "increased number of CD8-positive, alpha-beta T cells with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000909, GO_REF:0000031, GOC:tfm, PMID:20146720]
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Allelic Composition: Pax5m3Btlr/Pax5m3Btlr
Genetic Background: C57BL/6J-Pax5m3Btlr

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
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Allelic Composition: Pax5tm1Mbu/Pax5tm1Mbu
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Pax5tm3.1Mbu/Pax5tm3.1Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Pax5tm1Mbu/Pax5tm1Mbu
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0014050 increased B cell acute lymphoblastic leukemia incidence "an aggressive (fast-growing) type of leukemia (blood cancer) in which too many B-cell lymphoblasts (immature white blood cells) are found in the bone marrow and blood; it is the most common type of acute lymphoblastic leukemia (ALL)" [NCIT:C8644]
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Allelic Composition: Pax5tm3Mbu/Pax5+,Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
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Allelic Composition: Pax5m1Btlr/Pax5m1Btlr
Genetic Background: C57BL/6J-Pax5m1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031885 Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*  / complex / reaction






 

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