ENSMUSG00000015970


Mus musculus

Features
Gene ID: ENSMUSG00000015970
  
Biological name :Chdh
  
Synonyms : Chdh / Choline dehydrogenase, mitochondrial / Q8BJ64
  
Possible biological names infered from orthology : choline dehydrogenase / Q8NE62
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: B
Gene start: 30009023
Gene end: 30040527
  
Corresponding Affymetrix probe sets: 10413517 (MoGene1.0st)   1455435_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000065542
Ensembl peptide - ENSMUSP00000112916
NCBI entrez gene - 218865     See in Manteia.
MGI - MGI:1860776
RefSeq - NM_172264
RefSeq - NM_001136240
RefSeq - NM_175343
RefSeq Peptide - NP_001129712
RefSeq Peptide - NP_758468
RefSeq Peptide - NP_780552
swissprot - Q8BJ64
Ensembl - ENSMUSG00000015970
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chdhENSDARG00000100304Danio rerio
 CHDHENSGALG00000005363Gallus gallus
 CHDHENSG00000016391Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000172  Glucose-methanol-choline oxidoreductase, N-terminal
 IPR007867  Glucose-methanol-choline oxidoreductase, C-terminal
 IPR011533  Oxygen-dependent choline dehydrogenase
 IPR012132  Glucose-methanol-choline oxidoreductase
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019285 glycine betaine biosynthetic process from choline IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0008812 choline dehydrogenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016614 oxidoreductase activity, acting on CH-OH group of donors IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA


Pathways (from Reactome)
Pathway description
Choline catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Chrna7tm1Bay/Chrna7tm1Bay,Chrnb2tm1Mdb/Chrnb2tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002674 abnormal sperm motility "anomalies in the mobility of the spermatozoa" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Chrna7tm1Bay/Chrna7tm1Bay,Chrnb2tm1Mdb/Chrnb2tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
Show

Allelic Composition: Chrna7tm1Bay/Chrna7tm1Bay,Chrnb2tm1Mdb/Chrnb2tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011632 dilated mitochondria "the luminal space of the mitochondria is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith]
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Allelic Composition: Chrna7tm1Bay/Chrna7tm1Bay,Chrnb2tm1Mdb/Chrnb2tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011635 abnormal mitochondrial crista morphology "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061]
Show

Allelic Composition: Chrna7tm1Bay/Chrna7tm1Bay,Chrnb2tm1Mdb/Chrnb2tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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