ENSMUSG00000016194


Mus musculus

Features
Gene ID: ENSMUSG00000016194
  
Biological name :Hsd11b1
  
Synonyms : Hsd11b1 / hydroxysteroid 11-beta dehydrogenase 1 / P50172
  
Possible biological names infered from orthology : P28845
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H6
Gene start: 193221634
Gene end: 193264075
  
Corresponding Affymetrix probe sets: 10361234 (MoGene1.0st)   1449038_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124142
Ensembl peptide - ENSMUSP00000016338
Ensembl peptide - ENSMUSP00000123849
Ensembl peptide - ENSMUSP00000124693
Ensembl peptide - ENSMUSP00000125620
NCBI entrez gene - 15483     See in Manteia.
MGI - MGI:103562
RefSeq - XM_006497228
RefSeq - NM_001044751
RefSeq - NM_008288
RefSeq - XM_006497227
RefSeq Peptide - NP_001038216
RefSeq Peptide - NP_032314
swissprot - P50172
swissprot - Q3TJI8
swissprot - F6TSI8
swissprot - Q4JHD9
swissprot - F2Z3U6
Ensembl - ENSMUSG00000016194
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000028858Gallus gallus
 ENSGALG00000001369Gallus gallus
 P28845ENSG00000117594Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR020904  Short-chain dehydrogenase/reductase, conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0030324 lung development IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity IMP
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0070524 11-beta-hydroxysteroid dehydrogenase (NADP+) activity IEA


Pathways (from Reactome)
Pathway description
Glucocorticoid biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000010 abnormal abdominal fat pads "malformed or aberrant size of the encapsulated adipose tissue in the abdomen" [J:65146]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Hsd11b1tm1Yko/Hsd11b1tm1Yko
Genetic Background: B6.129P2(Cg)-Hsd11b1tm1Yko

 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hsd11b1tm1Yko/Hsd11b1tm1Yko
Genetic Background: B6.129P2(Cg)-Hsd11b1tm1Yko

 MP:0000642 enlarged adrenal glands "increased size of the endocrine gland" [J:40203]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: H6pdtm1Pmst/H6pdtm1Pmst,Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Hsd11b1tm1Ggla/Hsd11b1tm1Ggla,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: H6pdtm1Pmst/H6pdtm1Pmst,Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Hsd11b1tm1Ggla/Hsd11b1tm1Ggla,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001548 hyperlipidemia "abnormally high concentration of lipids in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex
Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Hsd11b1tm1Yko/Hsd11b1tm1Yko
Genetic Background: B6.129P2(Cg)-Hsd11b1tm1Yko

Allelic Composition: Hsd11b1tm1Ggla/Hsd11b1tm1Ggla,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pde6brd1/Pde6brd1
Genetic Background: involves: C3H

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Rab18m1Hongc/Rab18m1Hongc
Genetic Background: C57BL/6J-Rab18m1Hongc

Allelic Composition: Hsd11b1tm1a(KOMP)Wtsi/Hsd11b1+
Genetic Background: involves: C57BL/6Jcl * C57BL/6N

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hsd11b1tm1Ggla/Hsd11b1tm1Ggla,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Hsd11b1tm1Ggla/Hsd11b1tm1Ggla,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex
Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: H6pdtm1Pmst/H6pdtm1Pmst,Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex
Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: H6pdtm1Pmst/H6pdtm1Pmst,Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0003963 abnormal corticosterone level "anomalous blood or tissue concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Hsd11b1tm1a(KOMP)Wtsi/Hsd11b1tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6Jcl * C57BL/6N

Allelic Composition: Hsd11b1tm1a(KOMP)Wtsi/Hsd11b1+
Genetic Background: involves: C57BL/6Jcl * C57BL/6N

 MP:0003983 decreased cholesterol level "less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex
Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0005291 abnormal glucose tolerance "deviation from the normal response to oral consumption or intravenous injection of specified amounts of glucose; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hsd11b1tm1Ggla/Hsd11b1tm1Ggla,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Hsd11b1tm1Yko/Hsd11b1tm1Yko
Genetic Background: B6.129P2(Cg)-Hsd11b1tm1Yko

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex
Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dicer1em3Psv/Dicer1em3Psv
Genetic Background: involves: C57BL/6NCrl

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: H6pdtm1Pmst/H6pdtm1Pmst,Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd

 MP:0006319 abnormal epididymal fat pad "any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Hsd11b1tm1Yko/Hsd11b1tm1Yko
Genetic Background: B6.129P2(Cg)-Hsd11b1tm1Yko

Allelic Composition: Hsd11b1tm1.2Tuck/Hsd11b1tm1.2Tuck
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008243 abnormal foam cell morphology "any structural anomaly of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions" [CL:0000517]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex
Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex
Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex
Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H6pdtm1Pmst/H6pdtm1Pmst,Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0009417 skeletal muscle atrophy "a wasting of skeletal muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: H6pdtm1Pmst/H6pdtm1Pmst,Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0009428 decreased tibialis anterior weight "redcution in the weight of the muscle of the shin that is responsible for dorsiflexion and inversion of the foot" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: H6pdtm1Pmst/H6pdtm1Pmst,Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0010182 decreased susceptibility to weight gain "smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hsd11b1tm1.2Tuck/Hsd11b1tm1.2Tuck
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010227 decreased quadriceps weight "reduction in the weight of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H6pdtm1Pmst/H6pdtm1Pmst,Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0010400 increased liver glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0010401 increased skeletal muscle glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H6pdtm1Pmst/H6pdtm1Pmst,Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0010814 absent alveolar lamellar bodies "absence of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0010889 small alveolar lamellar bodies "decreased size of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0010890 decreased alveolar lamellar body number "reduced number of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0010934 increased subcutaneous adipose tissue amount "increase in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hsd11b1tm1a(KOMP)Wtsi/Hsd11b1tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6Jcl * C57BL/6N

 MP:0010993 decreased surfactant secretion "decreased production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0011702 abnormal fibroblast proliferation "anomaly in the ability of the a fibroblast cell population to undergo expansion by cell division" [MGI:csmith]
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Allelic Composition: Hsd11b1tm1a(KOMP)Wtsi/Hsd11b1tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6Jcl * C57BL/6N

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Hsd11b1tm1a(KOMP)Wtsi/Hsd11b1tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6Jcl * C57BL/6N

Allelic Composition: Hsd11b1tm1a(KOMP)Wtsi/Hsd11b1+
Genetic Background: involves: C57BL/6Jcl * C57BL/6N

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Dicer1em3Psv/Dicer1em3Psv
Genetic Background: involves: C57BL/6NCrl

 MP:0012172 abnormal amniotic fluid composition "any alteration in the expected chemical makeup of the watery liquid within the amnion that surrounds and cushions a growing fetus; normally, early in gestation, amniotic fluid is similar to maternal plasma, mainly water with electrolytes, and later in gestation, proteins, carbohydrates, lipids, phospholipids originating from the lungs, fetal cells, and urea are deposited in the fluid" [MGI:anna]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0020254 decreased collagen level "decreased level of the main structural protein of the various connective tissues in animals" [GOC:NV, PMID:11704682]
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Allelic Composition: Hsd11b1tm1a(KOMP)Wtsi/Hsd11b1tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6Jcl * C57BL/6N

Allelic Composition: Hsd11b1tm1a(KOMP)Wtsi/Hsd11b1+
Genetic Background: involves: C57BL/6Jcl * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000016194 P50172 / Hsd11b1 / hydroxysteroid 11-beta dehydrogenase 1 / P28845*  / complex






 

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