ENSMUSG00000017057


Mus musculus

Features
Gene ID: ENSMUSG00000017057
  
Biological name :Il13ra1
  
Synonyms : Il13ra1 / Interleukin-13 receptor subunit alpha-1 / O09030
  
Possible biological names infered from orthology : P78552
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A3.3
Gene start: 36112110
Gene end: 36171259
  
Corresponding Affymetrix probe sets: 10599174 (MoGene1.0st)   1425625_at (Mouse Genome 430 2.0 Array)   1427164_at (Mouse Genome 430 2.0 Array)   1427165_at (Mouse Genome 430 2.0 Array)   1451775_s_at (Mouse Genome 430 2.0 Array)   1454783_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033418
NCBI entrez gene - 16164     See in Manteia.
MGI - MGI:105052
RefSeq - NM_133990
RefSeq Peptide - NP_598751
swissprot - O09030
Ensembl - ENSMUSG00000017057
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il13ra2ENSDARG00000039436Danio rerio
 IL13RA1ENSGALG00000044480Gallus gallus
 P78552ENSG00000131724Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O88786 / Il13ra2 / Interleukin-13 receptor subunit alpha-2 / Q14627*ENSMUSG0000003128921
Il5ra / P21183 / Interleukin-5 receptor subunit alpha / Q01344*ENSMUSG0000000536420


Protein motifs (from Interpro)
Interpro ID Name
 IPR003532  Short hematopoietin receptor, family 2, conserved site
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR015321  Type I cytokine receptor, cytokine-binding domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000704 abnormal thymus development "anomaly in the formation and/or differentiation of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0001602 impaired myelopoiesis "atypical process of bone marrow cell formation and/or the formation of bone marrow-derived blood cells with the result of fewer of these cells being formed" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0002335 decreased airway responsiveness "less easily provoked into bronchoconstriction during bronchial provocation testing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rtel1tm1.1Hdin/Rtel1tm1.1Hdin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rtel1tm1.1Hdin/Rtel1tm1.1Hdin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rtel1tm1.1Hdin/Rtel1tm1.1Hdin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rtel1tm1.1Hdin/Rtel1tm1.1Hdin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rtel1tm1.1Hdin/Rtel1tm1.1Hdin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rtel1tm1.1Hdin/Rtel1tm1.1Hdin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rtel1tm1.1Hdin/Rtel1tm1.1Hdin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rtel1tm1.1Hdin/Rtel1tm1.1Hdin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rtel1tm1.1Hdin/Rtel1tm1.1Hdin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0008090 increased T-helper 2 cell number "greater number of the subset of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rtel1tm1.1Hdin/Rtel1tm1.1Hdin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Rtel1tm1.1Hdin/Rtel1tm1.1Hdin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Rtel1tm1.1Hdin/Rtel1tm1.1Hdin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0008626 increased circulating interleukin-5 level "increase in the amount in the blood of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Rtel1tm1.1Hdin/Rtel1tm1.1Hdin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex / reaction
 ENSMUSG00000020383 Il13 / P20109 / Interleukin-13 / P35225*  / complex / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000000869 Il4 / P07750 / Interleukin-4 / P05112*  / complex / reaction
 ENSMUSG00000037104 Socs5 / O54928 / Suppressor of cytokine signaling 5 / O75159*  / complex / reaction
 ENSMUSG00000030748 Il4ra / P16382 / Interleukin-4 receptor subunit alpha Soluble interleukin-4 receptor subunit alpha / IL4R* / P24394* / interleukin 4 receptor*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex
 ENSMUSG00000002147 Stat6 / P52633 / Signal transducer and transcription activator 6 / P42226* / signal transducer and activator of transcription 6*  / complex / reaction
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex / reaction






 

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