ENSMUSG00000031289


Mus musculus

Features
Gene ID: ENSMUSG00000031289
  
Biological name :Il13ra2
  
Synonyms : Il13ra2 / Interleukin-13 receptor subunit alpha-2 / O88786
  
Possible biological names infered from orthology : Q14627
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: F2
Gene start: 147383476
Gene end: 147429192
  
Corresponding Affymetrix probe sets: 10607206 (MoGene1.0st)   1422177_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033646
Ensembl peptide - ENSMUSP00000108446
NCBI entrez gene - 16165     See in Manteia.
MGI - MGI:1277954
RefSeq - XM_017318395
RefSeq - NM_001306059
RefSeq - NM_008356
RefSeq - XM_006528707
RefSeq - XM_006528708
RefSeq Peptide - NP_001292988
RefSeq Peptide - NP_032382
swissprot - O88786
Ensembl - ENSMUSG00000031289
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il13ra2ENSDARG00000039436Danio rerio
 IL13RA2ENSGALG00000020316Gallus gallus
 Q14627ENSG00000123496Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O09030 / Il13ra1 / Interleukin-13 receptor subunit alpha-1 / P78552*ENSMUSG0000001705723
Il5ra / P21183 / Interleukin-5 receptor subunit alpha / Q01344*ENSMUSG0000000536421


Protein motifs (from Interpro)
Interpro ID Name
 IPR003532  Short hematopoietin receptor, family 2, conserved site
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR015321  Type I cytokine receptor, cytokine-binding domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002638 negative regulation of immunoglobulin production IMP
 biological_processGO:0016064 immunoglobulin mediated immune response IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0043305 negative regulation of mast cell degranulation IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apptm1.1Wevn/Apptm1.1Wevn
Genetic Background: B6.129S6(FVB)-Apptm1.1Wevn

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008609 decreased circulating interleukin-13 level "reduction in the amount in the blood of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0020344 abnormal susceptibility to injury induced morbidity/mortality "differences from the expected moribund state caused by trauma, especially that by physical means" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Apptm1.1Wevn/Apptm1.1Wevn
Genetic Background: B6.129S6(FVB)-Apptm1.1Wevn

 MP:0030002 increased lung apoptosis "acceleration in the timing or in the number of cells of the lung undergoing programmed cell death" [ORCID:orcid.org/0000-0002-6490-7723, PMID:17589521]
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Allelic Composition: Apptm1.1Wevn/Apptm1.1Wevn
Genetic Background: B6.129S6(FVB)-Apptm1.1Wevn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020383 Il13 / P20109 / Interleukin-13 / P35225*  / complex / reaction






 

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