ENSMUSG00000017670


Mus musculus
domainElmo2cellbindingpleckstrinhomologyelmoarmadillo-likehelicalph-likesuperfamilyarmadillo-typefoldunknownfunctiondufengulfmentmotilityproteinphagocytosisapoptoticprocesscytoskeletonorganizationmigrationchemotaxiscell-celladhesioncytoplasmcytosolmembrane

Features
Gene ID: ENSMUSG00000017670
  
Biological name :Elmo2
  
Synonyms : Elmo2 / Engulfment and cell motility protein 2 / Q8BHL5
  
Possible biological names infered from orthology : engulfment and cell motility 2 / Q96JJ3
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H3
Gene start: 165288031
Gene end: 165326479
  
Corresponding Affymetrix probe sets: 10489660 (MoGene1.0st)   1436011_at (Mouse Genome 430 2.0 Array)   1456098_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117124
Ensembl peptide - ENSMUSP00000119682
Ensembl peptide - ENSMUSP00000123232
Ensembl peptide - ENSMUSP00000071619
Ensembl peptide - ENSMUSP00000073691
Ensembl peptide - ENSMUSP00000091887
Ensembl peptide - ENSMUSP00000099377
Ensembl peptide - ENSMUSP00000099380
Ensembl peptide - ENSMUSP00000114303
Ensembl peptide - ENSMUSP00000116124
NCBI entrez gene - 140579     See in Manteia.
MGI - MGI:2153045
RefSeq - XM_017315487
RefSeq - XM_011239284
RefSeq - XM_011239286
RefSeq - XM_011239285
RefSeq - NM_001302752
RefSeq - NM_001302754
RefSeq - NM_080287
RefSeq - NM_207706
RefSeq Peptide - NP_001289683
RefSeq Peptide - NP_001289681
RefSeq Peptide - NP_525026
RefSeq Peptide - NP_997589
swissprot - Q5GMG0
swissprot - Q8BHL5
swissprot - D6RHT3
swissprot - A2A5A7
swissprot - F6YXR3
swissprot - F6XD63
Ensembl - ENSMUSG00000017670
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 elmo2ENSDARG00000063527Danio rerio
 ELMO2ENSGALG00000007246Gallus gallus
 ELMO2ENSG00000062598Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Elmo1 / Q8BPU7 / Engulfment and cell motility protein 1 / Q92556* / engulfment and cell motility 1*ENSMUSG0000004111274
Elmo3 / Q8BYZ7 / Engulfment and cell motility protein 3 / Q96BJ8* / engulfment and cell motility 3*ENSMUSG0000001479150


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR006816  ELMO domain
 IPR011989  Armadillo-like helical
 IPR011993  PH-like domain superfamily
 IPR016024  Armadillo-type fold
 IPR024574  Domain of unknown function DUF3361
 IPR030713  Engulfment and cell motility protein 2


Gene Ontology (GO)
establishment of localizationcell deathcellular component organizationlocalization of cellmovement of cell or subcellular componentresponse to external stimulusresponse to chemicalcellular response to stimuluscell adhesionestablishment of localizationcell deathcellular component organizationlocalization of cellmovement of cell or subcellular componentresponse to external stimulusresponse to chemicalcellular response to stimuluscell adhesionestablishment of localizationcell deathcellular component organizationlocalization of cellmovement of cell or subcellular componentresponse to external stimulusresponse to chemicalcellular response to stimuluscell adhesionestablishment of localizationcell deathcellular component organizationlocalization of cellmovement of cell or subcellular componentresponse to external stimulusresponse to chemicalcellular response to stimuluscell adhesionestablishment of localizationcell deathcellular component organizationlocalization of cellmovement of cell or subcellular componentresponse to external stimulusresponse to chemicalcellular response to stimuluscell adhesionestablishment of localizationcell deathcellular component organizationlocalization of cellmovement of cell or subcellular componentresponse to external stimulusresponse to chemicalcellular response to stimuluscell adhesionestablishment of localizationcell deathcellular component organizationlocalization of cellmovement of cell or subcellular componentresponse to external stimulusresponse to chemicalcellular response to stimuluscell adhesionestablishment of localizationcell deathcellular component organizationlocalization of cellmovement of cell or subcellular componentresponse to external stimulusresponse to chemicalcellular response to stimuluscell adhesionestablishment of localizationcell deathcellular component organizationlocalization of cellmovement of cell or subcellular componentresponse to external stimulusresponse to chemicalcellular response to stimuluscell adhesionestablishment of localizationcell deathcellular component organizationlocalization of cellmovement of cell or subcellular componentresponse to external stimulusresponse to chemicalcellular response to stimuluscell adhesionestablishment oestablishment of localizationcell deathcell deathcellular componcellular component organizationlocalization oflocalization of cellmovement of celmovement of cell or subcellular componentresponse to extresponse to external stimulusresponse to cheresponse to chemicalcellular responcellular response to stimuluscell adhesioncell adhesion
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellcellmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0060326 cell chemotaxis ISS
 biological_processGO:0098609 cell-cell adhesion IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0016020 membrane ISO
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding ISO


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / complex / reaction
 ENSMUSG00000023951 Vegfa / Q00731 / vascular endothelial growth factor A / P15692*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000044813 Shb / Q6PD21 / SH2 domain-containing adapter protein B / Q15464* / AL138752.2* / SH2 domain containing adaptor protein B*  / complex / reaction
 ENSMUSG00000029528 Pxn / Q8VI36 / Paxillin / P49023*  / complex / reaction
 ENSMUSG00000002033 Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*  / complex / reaction
 ENSMUSG00000005763 Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*  / complex / reaction
 ENSMUSG00000015947 Fcgr1 / P26151 / High affinity immunoglobulin gamma Fc receptor I / Q92637* / FCGR1A* / FCGR1B* / P12314* / Fc fragment of IgG receptor Ib* / Fc fragment of IgG receptor Ia*  / complex / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction
 ENSMUSG00000059089 Fcgr4 / A0A0B4J1G0 / Low affinity immunoglobulin gamma Fc region receptor IV / P08637* / FCGR3A* / FCGR3B* / O75015* / Fc fragment of IgG receptor IIIa* / Fc fragment of IgG receptor IIIb*  / complex / reaction
 ENSMUSG00000058325 Dock1 / Q8BUR4 / Dedicator of cytokinesis protein 1 / Q14185* / dedicator of cytokinesis 1*  / complex
 ENSMUSG00000062960 Kdr / kinase insert domain receptor / P35968*  / complex / reaction
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / complex / reaction
 ENSMUSG00000031955 Bcar1 / Q61140 / Breast cancer anti-estrogen resistance protein 1 / P56945* / BCAR1, Cas family scaffolding protein*  / complex / reaction






 

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